Follow us on Twitter Lifestyle Research Updates

July 2014                                            Cancernet.co.uk

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 booksWe highlight research and resources from around the World which improve our understanding lifestyle and cancer and how it can influence the risk of cancer, well-being and reduce the risk of relapse after treatments.  

 

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 Follow us on Twitter Nitrate rich meats linked to increased risk of renal cancer

meat A study of 49,1841 participants within the NIH-AARP study followed for 9 years showed that nitrites from meat but not vegetables increased renal cancer risk. Nitrates are converted to nitrites by gut bacteria, then react with amines and amides in meat to form carcinogenic N-nitrosos compounds (NOC's). Extra nitrates are often added to processed meat to enhance coulour and taste. Although nitrates are also found in some green vegetables they do not contain amines required for nitrosation and also contain vitamin C and other anti-oxidants which inhibit it - more

 

Follow us on Twitter Indoor tanning increases the risk of melanoma - even if you don't burn

sunbeds A study from the Masonic Cancer Centre Minnesota has dispelled the myth that indoor tanning is safe unless users burnt . They compared1167 melanoma patients with 1101 controls.  Participants completed a questionnaire and telephone interview and the results were adjusted for sociodemographic factors (eg., age, sex, income, education), eye, hair, and skin color, number of freckles and moles, family history of melanoma, lifetime sun exposure and sunscreen use.  They found that melanoma patients reporting zero lifetime burns were still nearly four times more likely to be indoor tanners than control subjects. - tips on safe tanning

 

Follow us on Twitter Another study links metabolic syndrome with cancer

fat man An Italian case controlled study included 185 cases of hepatocellular cancer with matched controls. There was a four increased risk of cancer if individuals had two or more components of metabolic syndrome (diabetes and BMI >30 kg/m2). If they were Hep B +ve the risk was higher. Both insulin resistance and obesity cause fatty liver which produce adipkines and VEGF expression oxidant stress and mitochondrial dysfunction leading to an increased risk of DNA damage. (BJC, 108, 222-8) - more about lifestyle and cancer

 

Follow us on Twitter Further evidence that a polyphenol rich diet reduces breast cancer relapse risk

green tea A prospective follow up study of 2522 postmenopausal women treated with breast cancer was performed in Germany between 2001-9. They found that eating unhealthily (high meat, processed meat, sugar and deep fried fatty foods) increased the overall mortality. On the other hand, eating a healthy diet (high vegetables, fruit, vegetable oils, and polyphenol rich herbs and spices) improved their overall mortality and reduced their relapse rate. (BJC, 108,188-92) - more about polyphenol rich diets

 

 Follow us on Twitter PSA relapse after treatment - delaying hormones is safe and allows lifestyle interventions

 

blood tests A study involving 14,000 men, 2,012 of whom had a PSA relapse after radical prostatectomy or radiation therapy suggested deferred anti-androgen therapy is better than immediate intervention. The Prostate Strategic Urologic Research Endeavor, showed men who deferred up to 2 years until they presented with metastasis, symptoms, or a short PSA doubling time had a better qol and no difference in survival. This also allows for lifestyle interventions such as Pomi-T which showed that PSA progression slowed precisely in this group - more 

 

 Follow us on Twitter Fish intake and exercise reduces the relapse rate after bowel cancer

fish A multinational study involving 1,515 colon cancer patients from was published recently by a team from Michigan State University. Researchers asked patients about their diet, exercise habits, and whether they smoked or consumed alcohol. They found that people who eat fish less than twice a week or exercised for less than an hour each week were about 2.5 times more likely to have a recurrence of their colon cancer after their initial treatments finished. - read more

 
Follow us on Twitter Disturbed sleep increases risk of colorectal cancer
sleep A study of 75,828 postmenopausal women with the Women's Health Initiative Observational study linked extreme sleep patterns with an increased risk of colorectal cancer. The authors felt this carcinogenic effect was caused by a distruption of the circadian rhythm which can effect the efficiency of DNA repair, reduce glucose metabolism and suppress immunity. Those sleep <5 and > 9 hours where most at risk (BJC, 2013, 108, 213-21) - see sleep hygiene tips

Follow us on Twitter Exposure to organic solvents in early life increases the risk of breast cancer

breast pain A recent study has linked exposure to xenoestrogenic organic solvents with breast cancer. The analysis of 50,000 women was part of the Sister Study, an ongoing study of women whose sisters have had breast cancer but who, when they enrolled, did not have breast cancer themselves. Women who had exposure between puberty and first child had the risks. These included clinical laboratory technicians, house cleaners, and factory workers - about xenoestrogens

 
Follow us on Twitter Stopping statins in patients with advanced cancer has several advantages

calcium vit d Stopping statins in patients with advanced cancer resulted in improved overall quality of life, no increased deaths and saved money. This study presented at ASCO, from the University of Colorado Cancer Centre, studied 381 patients who faced the likelihood of dying within a year. Among the 192 study patients who stopped their statins, most had a better survival and had less tablets to take. The saving of 440 multiplied across the whole NHS would save millions per year  -read more

 Follow us on Twitter New study sheds more light on risk of skin cancer after sun exposure

A large study of women investigated the effect of sun exposure in adulthood and early life. Those who had at least five blistering sunburns when they were 15 to 20 years old had a 68% increased risk for basal cell carcinoma and squamous cell carcinoma, and an 80% increased risk for melanoma. Those who were exposed to the highest amounts of cumulative ultraviolet radiation in adulthood had no increased risk for melanoma, but had a 2.4-fold increased risk for developing basal cell carcinoma and squamous cell carcinoma. - about sensible sun exposure

Follow us on Twitter Pomi-T study - fully paper published

pomi-t-green The final results of the landmark double blind RCT Pomi-T study have been published this week in the Nature journal Prostate cancer and Prostate Diseases. It found a significant effect on the rate of PSA progression and  men were 30% more likely to stay on surveillance compared to placebo. MRI images of disease tended to correlate with PSA levels and there was no effect on testosterone.

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Follow us on Twitter New iphone app make it easier to calculate and display PSA doubling time 
The rate of rise of PSA (potential PSA doubling time - PSAdt) is a much more sensitive measure of disease progression over a single level. This novel iphone app calculates the PSAdt within seconds. Not only that it produces an easily readable graph of both the PSA and PSAdt so you can easily see if an intervention is working - you can then email the graph to a computer to print out or physician to aid discussion - read more
Online micro-nutritional testing - optimise your nutritional status
nutritional testsMost top athletes measure their body's essential micro-nutrients to ensure they have the correct nutritional balance for optimal performance. These tests are now available for everyone especially those concerned about or who have survived cancer. A online micro-nutrient service has been developed by cancernet which measures over 50 of the bodies essential micro-nutrients and anti-cancer enzymes (read evidence base).  The results of the detailed blood test are issued with a comprehensive bespoke advice programme which empowers the recipient to a diet and lifestyle which corrects deficiencies and lowers excesses to restore optimal nutritional status - read more about micro-nutrient testing
Lifestyle and Cancer - the facts

Lifestyle after Cancer The 2011 edition of Lifestyle and Cancer dispells the myths by providing clear evidence based advice, to help readers cope with side effects, speed up recovey and reduce the risk of relapse after cancer  Order online

 

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Read foreword by Paula Radcliffe Free Chapter - Avoiding carcinogens