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 Lifestyle Research Updates
April 2014 Cancernet.co.uk
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 Could sildenafil-citrate increase the risk of Melanoma? | |
Sildenafil-citrate is a phosphodiesterase (PDE) 5A inhibitor. Recent studies have shown that BRAF activation down-regulates PDE5A levels which increases the invasiveness of melanoma cells. Over 25,0000 participants in the Health Professionals' Follow-up Study were questioned regarding its use. There was an increased association between their use and melanoma presentation but his does not prove a cause which would be very small - read more
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| High protein intake in middle age leads to greater cancer risk |  Research published in Cell Metabolism linked individuals who ate a diet high in animal proteins during middle age with a four times more likely chance of dying of cancer than contemporaries with low-protein diets - a risk factor, if accurate, comparable to smoking. Additionally, they were several times more likely to die of diabetes. The investigators also tested the relationship between protein intake and cancer progression in mice, saying that during a two-month experiment there was lower cancer incidence and significantly smaller average tumor size among mice on a low-protein diet.- read more |
| Good fluid intake reduces bladder cancer risk in women smokers | |
 A recent paper examined the association between total fluid intake and bladder cancer risk in women.Among heavy cigarette smokers, women with the highest quartile of total fluid intake had a 38% decrease in bladder cancer risk. This suggests fluid intake reduces bladder cancer risk probably by decreasing the contact time between carcinogens in urine and bladder epithelium Ref: Zhou et al International Journal of Cancer FEB 2014, DOI: 10.1002/ijc.28764 - quit
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| High fat intake increases risk of ER positive breast cancer |  Previous studies only showed a small increased breast cancer with a high fat intake but a further analysis of 337,327 women in the EPIC study (European Investigation Into Cancer and Nutrition) showed that compared with lowest (1st) quintile of total fat intake (43.2 g/d), the highest (5th) quintile (117.3 g/d) there was a significantly increased risk of estrogen receptor-positive/progesterone receptor-positive disease- read more |
Pomi-T study - fully paper published
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 The final results of the landmark double blind RCT Pomi-T study have been published this week in the Nature journal Prostate cancer and Prostate Diseases. It found a significant effect on the rate of PSA progression and men were 30% more likely to stay on surveillance compared to placebo. MRI images of disease tended to correlate with PSA levels and there was no effect on testosterone.
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| New iphone app make it easier to calculate and display PSA doubling time |  The rate of rise of PSA (potential PSA doubling time - PSAdt) is a much more sensitive measure of disease progression over a single level. This novel iphone app calculates the PSAdt within seconds. Not only that it produces an easily readable graph of both the PSA and PSAdt so you can easily see if an intervention is working - you can then email the graph to a computer to print out or physician to aid discussion - read more |
| New evidence for the importance of vitamin Vitamin D and breast cancer | |
 A recent overview of five international studies has added credibility to those who believe vitamin D deficiency is important contributing factor for breast cancer. They found that women with higher serum 25-hydroxy vitamin D [25(OH)D] at diagnosis were associated with longer survival. Specifically, patients in the highest quintile of 25(OH)D had approximately half the death rate from breast cancer as those in the lowest. Authors concluded that all patients with breast cancer should be restored to the normal range (30-80 ng/ml), with appropriate monitoring. - measure your vitamin D levels
Ref: Mohr et al Anticancer Research March 2014 vol. 34 no. 3 1163-1166
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| Free Gym membership reduces aromatase inhibitor associated joint pains | |
 The HOPE study enrolled 121 breast cancer who were taking aromatase inhibitors for an average of 1.5 years and experiencing at least mild arthralgias. Women who were randomised to a year long program of exercise had significantly less joint pain. Morever, a dose-response relationship was seen with exercise. That is, the more adherent patients had more improvement in joint pain. Those also given a free gym membership had even greater effect - read more
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| More evidence that Yoga after breast cancer eases pain and fatigue | |
 A randomised study, published in the Journal of Clinical Oncology, involving 191 women with breast cancer found that, after radiation treatment, yoga and stretching groups experienced decreases in pain and fatigue, compared controls. Additionally, months after the radiation treatment, the yoga group self-reported higher general health, and were also more likely than the other two groups to say that they found some kind of meaning of life from their cancer experience. Women in the yoga group had the greatest reduction in cortisol levels across the day, which reflected the ability of yoga to help regulate stress hormones. - read more about exercise after cancer
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| Online micro-nutritional testing - optimise your nutritional status |  Most top athletes measure their body's essential micro-nutrients to ensure they have the correct nutritional balance for optimal performance. These tests are now available for everyone especially those concerned about or who have survived cancer. A online micro-nutrient service has been developed by cancernet which measures over 50 of the bodies essential micro-nutrients and anti-cancer enzymes (read evidence base). The results of the detailed blood test are issued with a comprehensive bespoke advice programme which empowers the recipient to a diet and lifestyle which corrects deficiencies and lowers excesses to restore optimal nutritional status - read more about micro-nutrient testing |
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Lifestyle and Cancer - the facts
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 The 2011 edition of Lifestyle and Cancer dispells the myths by providing clear evidence based advice, to help readers cope with side effects, speed up recovey and reduce the risk of relapse after cancer Order online
A new scheme is also now available to advocacy groups - The publishers are able to supply at cost price to groups who can sell on to members at a discount Contact us about joinng this scheme
Read foreword by Paula Radcliffe Free Chapter - Avoiding carcinogens
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