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 Lifestyle Research Updates
June 2014 Cancernet.co.uk
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 PSA relapse after treatment - delaying hormones is safe and allows lifestyle interventions | |
 A study involving 14,000 men, 2,012 of whom had a PSA relapse after radical prostatectomy or radiation therapy suggested deferred anti-androgen therapy is better than immediate intervention. The Prostate Strategic Urologic Research Endeavor, showed men who deferred up to 2 years until they presented with metastasis, symptoms, or a short PSA doubling time had a better qol and no difference in survival. This also allows for lifestyle interventions such as Pomi-T which showed that PSA progression slowed precisely in this group - more
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| Fish intake and exercise reduces the relapse rate after bowel cancer |
 A multinational study involving 1,515 colon cancer patients from was published recently by a team from Michigan State University. Researchers asked patients about their diet, exercise habits, and whether they smoked or consumed alcohol. They found that people who eat fish less than twice a week or exercised for less than an hour each week were about 2.5 times more likely to have a recurrence of their colon cancer after their initial treatments finished. - read more |
| Disturbed sleep increases risk of colorectal cancer |  A study of 75,828 postmenopausal women with the Women's Health Initiative Observational study linked extreme sleep patterns with an increased risk of colorectal cancer. The authors felt this carcinogenic effect was caused by a distruption of the circadian rhythm which can effect the efficiency of DNA repair, reduce glucose metabolism and suppress immunity. Those sleep <5 and > 9 hours where most at risk (BJC, 2013, 108, 213-21) - see sleep hygiene tips
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| Exposure to organic solvents in early life increases the risk of breast cancer | |
 A recent study has linked exposure to xenoestrogenic organic solvents with breast cancer. The analysis of 50,000 women was part of the Sister Study, an ongoing study of women whose sisters have had breast cancer but who, when they enrolled, did not have breast cancer themselves. Women who had exposure between puberty and first child had the risks. These included clinical laboratory technicians, house cleaners, and factory workers - about xenoestrogens
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| Stoping statins in patients with advanced cancer has several advantages | |
 Stopping statins in patients with advanced cancer resulted in improved overall quality of life, no increased deaths and saved money. This study presented at ASCO, from the University of Colorado Cancer Centre, studied 381 patients who faced the likelihood of dying within a year. Among the 192 study patients who stopped their statins, most had a better survival and had less tablets to take. The saving of �440 multiplied across the whole NHS would save millions per year -read more
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| New study sheds more light on risk of skin cancer after sun exposure | |
 A large study of women investigated the effect of sun exposure in adulthood and early life. Those who had at least five blistering sunburns when they were 15 to 20 years old had a 68% increased risk for basal cell carcinoma and squamous cell carcinoma, and an 80% increased risk for melanoma. Those who were exposed to the highest amounts of cumulative ultraviolet radiation in adulthood had no increased risk for melanoma, but had a 2.4-fold increased risk for developing basal cell carcinoma and squamous cell carcinoma. - about sensible sun exposure
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| Could sildenafil-citrate increase the risk of Melanoma? | |
Sildenafil-citrate is a phosphodiesterase (PDE) 5A inhibitor. Recent studies have shown that BRAF activation down-regulates PDE5A levels which increases the invasiveness of melanoma cells. Over 25,0000 participants in the Health Professionals' Follow-up Study were questioned regarding its use. There was an increased association between their use and melanoma presentation but his does not prove a cause which would be very small - read more
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| Good fluid intake reduces bladder cancer risk in women smokers | |
 A recent paper examined the association between total fluid intake and bladder cancer risk in women.Among heavy cigarette smokers, women with the highest quartile of total fluid intake had a 38% decrease in bladder cancer risk. This suggests fluid intake reduces bladder cancer risk probably by decreasing the contact time between carcinogens in urine and bladder epithelium Ref: Zhou et al International Journal of Cancer FEB 2014, DOI: 10.1002/ijc.28764 - quit
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Pomi-T study - fully paper published
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 The final results of the landmark double blind RCT Pomi-T study have been published this week in the Nature journal Prostate cancer and Prostate Diseases. It found a significant effect on the rate of PSA progression and men were 30% more likely to stay on surveillance compared to placebo. MRI images of disease tended to correlate with PSA levels and there was no effect on testosterone.
- View channel 5 TV news clip
- Download full paper
- More about this supplement
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| New iphone app make it easier to calculate and display PSA doubling time |  The rate of rise of PSA (potential PSA doubling time - PSAdt) is a much more sensitive measure of disease progression over a single level. This novel iphone app calculates the PSAdt within seconds. Not only that it produces an easily readable graph of both the PSA and PSAdt so you can easily see if an intervention is working - you can then email the graph to a computer to print out or physician to aid discussion - read more |
| Online micro-nutritional testing - optimise your nutritional status |  Most top athletes measure their body's essential micro-nutrients to ensure they have the correct nutritional balance for optimal performance. These tests are now available for everyone especially those concerned about or who have survived cancer. A online micro-nutrient service has been developed by cancernet which measures over 50 of the bodies essential micro-nutrients and anti-cancer enzymes (read evidence base). The results of the detailed blood test are issued with a comprehensive bespoke advice programme which empowers the recipient to a diet and lifestyle which corrects deficiencies and lowers excesses to restore optimal nutritional status - read more about micro-nutrient testing |
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Lifestyle and Cancer - the facts
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 The 2011 edition of Lifestyle and Cancer dispells the myths by providing clear evidence based advice, to help readers cope with side effects, speed up recovey and reduce the risk of relapse after cancer Order online
A new scheme is also now available to advocacy groups - The publishers are able to supply at cost price to groups who can sell on to members at a discount Contact us about joinng this scheme
Read foreword by Paula Radcliffe Free Chapter - Avoiding carcinogens
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