JULY 2015

News for MCIRCC Members, Insiders and the U-M Critical Care Community

Visit the Virtual Institute
Research Spotlight
Funding Opportunities
Member Accolades
Dr. Tiba with the DRIVE device.

DRIVEResearch DRIVEs Toward New Vital Signs in Patient Monitoring

Non-invasive blood volume analysis method has potential to improve patient care with increased accuracy and reduced chance of complications.

Many acute and chronic medical and surgical conditions require health care providers to make accurate assessments of a patient's circulating blood volume. However, the current standards of care for determining volume status are not always accurate and can put the patient at risk.

In their search to define the "new normal" of critical care patient monitoring, MCIRCC Members Hakam Tiba, MD, Kevin Ward, MD, Albert Shih, PhD, and Barry Belmont, MS have developed a new vital sign measurement that accurately assesses a patient's circulating blood volume using non-invasive technology.

They call this innovation Dynamic Respiratory Impedance Volume Evaluation, a.k.a. DRIVE, which is based on the dynamic relationship between venous return, the function of the right ventricle, and its interaction with lung mechanics as key determinants of estimating intravascular volume status. "Essentially, we have found a correlation between a patient's ultrasound measures of the inferior vena cava diameter and our DRIVE bioimpedance measurements taken from the surface of a patient's arm," stated Dr. Tiba.

U-M and an industry sponsor are now in the process of exploring technology licensing following a recent on-site DRIVE demonstration. This new vital sign technology could transform critical care for trauma, heart failure, sepsis, burns and resuscitation by personalizing the diagnosis and treatment plan for volume and fluid management of the individual patient-in other words, allowing us to treat the person versus the disease.

Click here to read the full story.

ChipHeartbeat on a Chip


Gravity-powered chip, developed at the Biointerfaces Institute and MCIRCC, which mimics a human heartbeat outside the body could improve pharmaceutical testing.


MCIRCC Associate Director Shuichi Takayama, PhD and team have made new developments in the "lab on a chip" category--a class of microfluidic devices that can perform complex laboratory functions in a tiny space-with their gravity-powered chip that can mimic fundamental physical rhythms.


The chip uses an intricate network of microscopic, gravity-driven channels, capacitors and switches to make liquids flow across it in an unlimited variety of pulses and flow rates. It enables researchers to test new therapies on human cell samples that have been injected into the device, in an environment that closely mimics conditions inside the body.


"This chip gives us a bridge between the petri dish and the patient," Takayama said. "Cells behave much more naturally when they're subjected to the pulsing rhythms inside the body, as opposed to sitting in a static environment in the lab. So, by duplicating those rhythms on a chip, we can perform much more accurate lab tests before we begin testing on patients."


Click here to read the full story.

MTRACU-M MTRAC Accepting Proposals until Tuesday, September 8

Year #3 for Fast Forward Commercialization Funding Program.

The U-M Medical School has issued a Request for Proposals for the U-M Michigan Translational Research and Commercialization for Life Sciences Program (U-M MTRAC).

Sponsored by the Medical School in partnership with the Office of the Vice President for Research, the Office of Technology Transfer, and the Michigan Economic Development Corporation, MTRAC supports funding for proof-of-concept and other early-stage development studies, regulatory guidance, and consultation and mentoring from industry and investment experts outside the University.

MTRAC is using Medical School Competition Space to manage the proposal submission process, and each proposal must have a Principal Investigator with efforted appointment at the Medical School.

Proposals will be evaluated on the basis of scientific merit, potential health care impact and significance, the potential for commercialization, and likelihood of obtaining further support.
In previous years, funding for 22 different proposals has been awarded in four target markets: devices, diagnostics, therapeutics, and healthcare IT. Click here to view those projects.

Instructions for proposal submission can be found at the U-M MTRAC website.

Proposals must contain a comprehensive research plan with deliverable milestones and are due Tuesday, September 8.

Questions? Contact Bradley Martin, Commercialization Program Director at 734-936-8577 or bradmart@med.umich.edu.


QAGot Questions? Get Answers! 


Real answers from real experts using the Virtual Institute Q&A Forum.


Often times the most challenging part of an equation is identifying the right expert, information insider, or gatekeeper to clear the pathway to your solution. This challenge is even more imposing with MCIRCC's membership base spanning seven different schools across campus.

To amplify information sharing and team collaboration among members, MCIRCC created the Virtual Institute's Q&A Forum. The Q&A Forum is an electronic discussion board where members are encouraged to hold conversations in the form of posted messages.

How it works:

1. Submit a question, inquiry, or idea for feedback
2. This "post" is uploaded for comment by the MCIRCC critical care community
3. Email notification of this same post is pushed to members to urge timely commentary
4. Members can then "answer" or respond to this post and ongoing messages

This is a great way to kick-start conversations whether you're looking for a key expert, a solution to a problem, or a relationship with an industry organization or grant office. The uses are endless!

Want to know more about the technology and using the Q&A Forum? Click here to visit the dedicated help center page.
We encourage you to bookmark www.micircc.org/vip or create a shortcut on your desktop to make regular log-in easy and hassle free.

If you have yet to visit the Virtual Institute to setup your user account, be sure to revisit your instructional login communications or click here to review the First Time Login Guide.

Contact aarnould@umich.edu with general questions or if you experience technical problems with the site.

DanStuartMCIRCC Welcomes New Solutions Architect

With over 20 years of experience in writing and designing software applications, Dan Stuart joins MCIRCC as a member of the core team responsible for building and deploying MCIRCC's Big Data Analytic Platform and Critical Care Data Mart. Leveraging his expertise in developing automated software build/test/deployment pipelines, hardware solutions and performance optimization, Dan manages the team's requirements collection process and software build to bridge the gap between MCIRCC's technology solutions with the hospital- and patient-generated data.

Prior to joining MCIRCC, Dan worked in various leadership, development and operational technology roles at the University of Michigan, BOSSdev, Benefit Outsourcing Solutions, and Washtenaw Community College. As a hobby, he is combining his software knowledge with micro controllers and sensors to build a robot modeled after the human body.

You can contact Dan at 248-842-4724 or dkstuart@umich.edu.

MCIRCC is excited to announce that it is a defined center in the Michigan Experts (SciVal Experts) database.

An interactive tool to help facilitate an evidence-based approach to research and collaboration strategies, Michigan Experts aggregates information from numerous internal and external sources and enables researchers and organizations to build reports, manage researcher profiles, facilitate research networking and expertise discovery, and much more. Click here for more information on using Michigan Experts.

As a MCIRCC member with a Michigan Experts profile, you will notice the "Center for Integrative Research in Critical Care" is now listed under your identified organizations, depending on when your membership became official.

MCIRCC plans to share more about using this dynamic tool at a later date, but in the meantime, click here to access MCIRCC in the Michigan Experts database.
If you are speaking with the media about your work in critical care research or are working with the U-M News Service or U-M Health System Public Relations on a health care related press release, article, or other news item, please mention your affiliation with the U-M Center for Integrative Research in Critical Care.
MCIRCC salutes the achievements of it members in their pursuit of academic excellence, industry thought leadership, and initiatives of personal passion. Because together, leveraging each of our individual triumphs as a team, we have the power to transform critical care medicine. If you have a recent achievement, award, or accolade to brag about contact aarnould@umich.edu with the details.
JRubinJonathan Rubin Wins MTRAC Kickstart Award

Jonathan Rubin, MD, PhD has received funding for his project "Real-Time Ultrasound Measurement of Local Lung Ventilation"--an ultrasound-based technique that assesses local lung ventilation using strain measurements of the lung surface during breathing. This award represents continuation funding for his 2014 Grand Challenge project.

This technology could yield the first portable, safe, and real-time method for assessing local pulmonary function in a myriad of important conditions including mechanical ventilator function monitoring, pulmonary edema, and adult respiratory distress syndrome.

Kickstart Awards, made possible by U-M MTRAC, enable Medical School research faculty to develop proof of concept for innovative technologies. This award is aimed to enhance the commercial potential of a technology to the point of translation and possible inclusion in MTRAC or other research funding programs. Click here to learn more about MTRAC Kickstart.

NeumarRobert Neumar Receives AHA Funding Award


Robert Neumar, MD has received an award from the American Heart Association for his project "Optimizing Extracorporeal Cardiopulmonary Resuscitation (ECPR) for Refractory Cardiac Arrest."

The project, which aims to determine whether giving a blood thinner during cardiac arrest improves the efficacy of ECPR, is approved for multi-year funding starting with $70,065 in July followed by an additional $69,407 the following year upon demonstration of adequate progress and other factors.

If successful, this therapy will give paramedics more time to transport patients to the hospital, and doctors more time to start ECPR in the Emergency Department when standard care fails.

NYTBrahmajee Nallamothu Quoted in NYT


A New York Times article, A Sea Change in Treating Heart Attacks, looks at why death rates for heart disease have dropped by 38 per cent in a decade. Brahmajee Nallamothu, MD, MPH and his peers explain that a move toward streamlined emergency treatment is one reason.

Dr. Cooke
Dr. Sjoding

Sjoding_CookeSjoding and Cooke Editorial in CCM Journal

An editorial in the Critical Care Medicine Journal by Michael Sjoding, MD and Colin Cooke, MD, MSc, MS titled "Chronic Critical Illness: A Growing Legacy of Successful Advances in Critical Care*" looks at the rise of chronic critical illness.

The editorial comments on the paper "The Epidemiology of Chronic Critical Illness in the United States" in which the authors determined that the incidence of chronic critical illness was not only high, but also increasing every year of their study.
Dr. Ward
Dr. Tiba

Tiba_WardTiba, Alam and Ward Published in Trauma and Acute Care Surgery


M. Hakam Tiba, MD, Hasan Alam, MD and Kevin Ward, MD have been published in The Journal of Trauma and Acute Care Surgery for their work on hemorrhage research.

Drs. Tiba and Ward's paper "Tissue oxygenation
Dr. Alam
monitoring using resonance Raman spectroscopy during hemorrhage," published in February 2014, explores the use of resonance Raman spectroscopy (RRS) as a method to monitor tissue oxygenation in trauma patients.

Drs. Tiba, Alam and Ward's paper "Use of pelvic hemostasis belt to control lethal pelvic arterial hemorrhage in a swine model," published in March 2015, tests a prototype device called the pelvic hemostasis belt for its ability to reduce or halt blood flow in a lethal model of pelvic arterial injury.

As THE network "hub" between academic scientists, clinical researchers, industry partners, and funding sources, MCIRCC is committed to providing member researchers with the innovation, financial, business, and commercialization guidance and resources you need to get your research to the bedside, faster. Click here for more information about becoming a MCIRCC member.


August 20

11:00 am - 2:00 pm


Medical Science Unit I - Circle Drive in Front of Building

1301 Catherine Street


Connect with the offices and labs here to serve you!  Spend a few hours hearing the "word on the street" about the latest collaboration and funding opportunities, and network in an informal atmosphere learning about new technologies and services available to biomedical researchers and staff.


Stop by and visit MCIRCC's booth to test your critical care knowledge, Jeopardy style.


Questions? Email Ann Curtis in the Office of Research at accurtis@umich.edu.


Click here to view participating offices and labs.

Click here for exhibitor information and table reservations.

RegionalSeminarNIH Regional Seminars on Program Funding and Grants Administration


October 14-16

Hilton San Diego Bayfront
1 Park Avenue

San Diego, CA 



The 2-day agenda for the NIH Regional Seminar offers 3 tracks: Administrators, New Investigators and All Interests.


The New Investigators track has been redesigned to provide step-by-step guidance on mapping your career, understanding the funding process and what can be expected up to the time of award. To add to the array of topic choices, special interest sessions are provided on topics like research integrity, data sharing, foreign collaborations, and more.

Opportunities with NIH & HHS Experts

Attendees are encouraged to sign up for the popular 1:1 Meet the Expert Chats. Attendees who take advantage of these 15 minute discussions repeatedly say it is one of the most valuable opportunities at the NIH Regional Seminar! NIH & HHS experts are on hand to meet specifically with attendees, answer questions and provide guidance.


Click here for more information and to register.

November 4, 18 and December 9
5:30 pm - 7:30 pm

NCRC, Building 520

MICHR offers a structured, three-part workshop designed to assist junior faculty and fellows who are preparing competitive career development grant applications (NIH K and VA CDA) for 2016 submission.

Participants will exchange drafts of proposal sections and receive peer critique and feedback from senior faculty experienced in NIH study section thinking. The workshop only "works" if participants have drafts to discuss.

Registrants MUST attend all three sessions. Your mentor is expected to attend Session 1 (November 4) or Session 2 (November 18).

Registration is required and closes on October 19.

Click here for more information and to register.

Download the MCIRCC Sepsis Portfolio Brochure

Download the Massey TBI Info Sheet

The U-M Center for Integrative Research in Critical Care (MCIRCC) is one of the world's first comprehensive research enterprises devoted to transforming critical care medicine by accelerating science and moving it from bench to bedside. To do this, MCIRCC brings together integrative teams comprised of world-class U-M scientists, clinicians, and engineers with industry partners and funding sources to develop and deploy cutting-edge solutions that elevate the care, outcomes, and quality of life of critically ill and injured patients and their families.