Sun Protection and Connective Tissue Disease
 As we spend more time outdoors, it is important to protect against the strong summer rays. Sunlight contains harmful ultraviolet rays that increase the risk of skin cancer, accelerate aging of the skin, and flare connective tissue disease. Sunlight that reaches the Earth's surface contains two types of ultraviolet (UV) light, both A and B. - UVB light is more damaging, causing sunburns and altering DNA in the body's cells.
- Sunlight contains about 10-20 times more UVA light, which penetrates the skin more deeply.
Both forms of UV radiation cause skin cancer and premature aging of the skin. Tanning beds also produce UVA and UVB radiation, often at much higher levels than the sun. Read more... |
RheumShorts: Fibromyalgia, Scleroderma, Spondylitis
 News in rheumatology this week included water therapy for fibromyalgia, Gleevec for the often-lethal interstitial lung disease in scleroderma, and a temporary setback for apremilast in ankylosing spondylitis. - Lung function was stabilized with imatinib in a large proportion of patients with systemic sclerosis interstitial lung disease unresponsive to cyclophosphamide.
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Health Insurance Claim Denied? Appeal!
 Few things are scarier than racking up medical bills and then learning that your health insurance company won't pay. It's a nightmare that could panic any policyholder. But before you worry about sinking into a black hole of medical debt, know that federal law offers a way to appeal. "When a claim is denied, consumers should not view that as the end of the story," says Katherine Vukadin, an assistant professor at Texas Southern University's Thurgood Marshall School of Law in Houston. The Affordable Care Act, or ACA -- the law popularly known as Obamacare -- gives a policyholder new rights to demand that an insurer reconsider any health claim denial. And then, if your plan reviews the case and still won't budge, you can appeal to an independent third party, which will make a decision the insurer must accept. Don't assume the process will be easy. "Appealing takes time and energy, on top of battling the underlying illness," Vukadin says. Read more... |
Emerging Role of Epigenetics in Systemic Sclerosis Pathogenesis
 Systemic sclerosis (scleroderma) is a connective tissue disease of unknown aetiology characterized by autoimmunity, inflammation, vascular abnormalities and ultimately fibrosis. Although great advances have been made in determining the molecular mechanisms of disease pathogenesis over the last decade, aided by new genetic screens, no current specific disease-modifying treatment is yet available. Epigenetics is defined as heritable changes that are not due to changes in DNA sequence, and there is at present intense research effort to understand the basic mechanisms of epigenetic regulation and how these impact diseases. Epigenetic modifications and dysregulation are associated now with autoimmune disease, inflammatory disease and cancer. Read abstract here... |