Epidemiology and Genomics Research

CANCER EPIDEMIOLOGY MATTERS E-NEWS 
JUNE 2016  
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Funding Opportunity AnnouncementsFunding1

RFA-HD-17-010
Global Network for Womens and Childrens Health Research Data Coordinating Center (U24)
Application Due Dates: Expiration Date: August 31, 2016

RFA-AA-17-006
U.S. - Russia Bilateral Collaborative Research Partnerships on the Prevention and Treatment of HIV/AIDS and HIV-Associated Comorbidities (R01)
Application Due Date: September 13, 2016
Expiration Date: September 14, 2016

Joint NSF/NIH Initiative on Quantitative Approaches to Biomedical Big Data
Application Due Date: September 28, 2016

RFA-AI-16-031
Limited Interaction Targeted Epidemiology (LITE) to Advance HIV Prevention (UG3/UH3)
Application Due Date: December 5, 2016
Expiration Date: December 6, 2016

PAR-16-297
Native American Research Centers for Health (S06)
Application Due Dates: July 27, 2016 and June 24, 2017
Expiration Date: July 28, 2017

PAR-16-292
Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21)

Application Due Dates: August 31, 2016; August 31, 2017; and August 31, 2018
Expiration Date: September 1, 2018

PAR-16-349
New Informatics Tools and Methods to Enhance U.S. Cancer Surveillance Research (UG3/UH3)
Application Due Dates: October 14, 2016; April 14, 2017; November 30, 2017; April 16, 2018; November 30, 2018; April 16, 2019
Expiration Date: April 17, 2019

PAR-16-278
Stimulating Innovations in Behavioral Intervention Research for Cancer Prevention and Control (R21)
Application Due Dates: Standard dates apply
Expiration Date: May 8, 2019

PA-16-295
Factors Underlying Differences in Female and Male Presentation for Dental, Oral, and Craniofacial Diseases and Conditions (R01)
Application Due Dates: Expiration Date: September 8, 2019
Grants Policy AnnouncementsGrants

Requests 
for InformationRequestinfo1

Cancer Moonshot Cancer Research Ideas
Submit ideas by July 1, 2016
Training AwardsTraining1

Fogarty Global Health Training Program

Fogarty HIV Research Training Program

PAR-16-280
Infrastructure Development Training Programs for Critical HIV Research at Low-and Middle-Income Country Institutions (G11)

Application Due Dates: August 25, 2016; August 23, 2017; and August 23, 2018
Expiration Date: August 24, 2018

PAR-16-284
Cancer Prevention, Control, Behavioral Sciences, and Population Sciences Career Development Award (K07)

Application Due Dates: Standard dates apply
Expiration Date: January 8, 2018

PAR-16-293
The NCI Transition Career Development Award (K22)
Application Due Dates: Standard dates apply
Expiration Date: January 8, 2018
Job OpportunitiesJob1

Program Director for Environmental Epidemiology


Upcoming
WorkshopsUpcoming1

SAVE THE DATE: NCI Cohort Consortium Annual Meeting
November 1-2, 2016
Bethesda, MD

9th Annual Conference on the Science of Dissemination and Implementation for Health
December 14-15, 2016
Washington, DC
Abstracts due August 4, 2016
Blog PostsBlog1
Douglas Lowy, M.D.
NCI Cancer Currents Blog

Douglas Lowy, M.D.
NCI Cancer Currents Blog

Genomic Data Commons Launches
Louis M. Staudt, M.D., Ph.D.
Center for Cancer Genomics Blog

Blood Test for Genetic Changes in Tumors Shows Promise as Alternative to Tumor Biopsy
NCI Staff
Cancer Currents Blog
Send Us Your IdeasSend1
EGRP encourages readers to submit items of interest to Cancer Epidemiology Matters E-News. EGRP reserves the right to decide whether or not materials are appropriate for inclusion.
About EGRPAbout1
The Epidemiology and Genomics Research Program (EGRP) in the Division of Cancer Control and Population Sciences (DCCPS) funds research in human populations to understand the causes of cancer and related outcomes.

The Program fosters interdisciplinary collaborations, as well as the development and use of resources and technologies to advance cancer research and translation of this research, which serve as the basis for clinical and public health interventions.
Contact UsContact1
Understanding Adducts to Address Cancer Prevention, Detection, and RisksAdducts
Uncovering the carcinogenic processes that cause tumors to emerge is an essential element of cancer prevention and control. One avenue for better understanding this process is the evaluation of adducts.

the exposome_ the sum of all exposures 
Diagram courtesy of cdc.gov
Adducts are combinations of two or more different molecules that, when joined, create a new and distinct type of molecule. In the case of various cancers, carcinogenic compounds may form bonds with cellular macromolecules such as DNA, RNA, and proteins to create adducts. The existence of these adducts may contribute to the underlying etiology and development of tumors and potentially serve as relevant markers of both internal and external exposures to cancer risk.

A number of epidemiologic studies have found an association between adduct levels--from certain environmental exposures such as cigarette smoke and organic pollutants--and risk of certain cancers. Advances in technology to characterize adducts--through genome-wide profiling of DNA adducts or other methods--have opened the field of "adductomics," which has vast potential for identifying, characterizing, and understanding the role of adducts and the distribution of adduct patterns. The study of these compounds can potentially increase knowledge of cancer etiology and opportunities for risk detection.

In order to learn more about the role of adducts in cancer etiology, The National Cancer Institute (NCI) and the National Institute of Environmental Health Sciences (NIEHS) have co-sponsored multiple funding opportunities to support research projects focused on adducts to cellular macromolecules as indicators of exposures to cancer risk factors.  
This research is intended to advance the area of cancer detection, cancer prevention, and assessing cancer risks in human populations and subgroups.

For cancer epidemiology questions related to these funding opportunities, contact NCI's Gabriel Lai, Ph.D., Program Director, Environmental Epidemiology Branch, Epidemiology and Genomics Research Program. 

To learn more about how internal and external exposure can affect human health, visit the National Institute for Occupational Safety and Health (NIOSH) website.  
Does the NIH Genomic Data Sharing Policy Apply to Your Study?GDS
question marks
The NIH Genomic Data Sharing (GDS) policy applies to competing grants and contract proposals submitted on or after January 25, 2015 that are generating large-scale human or non-human genomic data, and may also apply to some smaller-scale studies.

But how do you determine whether your data qualifies as "large-scale"? And which smaller-scale studies are subject to the policy? If the GDS policy does apply, what are your responsibilities?

Thresholds for Large-Scale Studies
The NCI has developed specific guidelines for determining whether data being generated meets the requirements for consideration as "large-scale."  Investigators should consult with their Program Directors (PDs) as soon as possible to determine whether their study meets these threshold requirements. Learn more about thresholds for large-scale projects.

Smaller Scale Studies
The NCI may require submission of smaller-scale studies under the GDS depending on the state of the science, the needs of the research community, and the programmatic priorities of the institute (e.g., projects examining rare cancers or projects focusing on under-studied populations).  Investigators are expected to consult with their Program Officials as soon as possible to determine whether their smaller scale study is being prioritized. Learn more about which smaller-scale studies are expected to submit data.

Pre-Award Responsibilities Under GDS
The proposal planning phase is the appropriate time for determining whether your work is within the scope of the policy and to start completing the following required documents:
While there are instances where data sharing is not appropriate, exceptions to the NIH GDS Policy are rare.

If you determine the work proposed in your application falls under the NIH Genomic Data Sharing policy, you are strongly encouraged to include a statement in a cover letter upon submission. For more information about NCI's implementation of this policy, please visit NCI's Genomic Data Sharing Implementation Page.

Investigators who have questions about their grants or this policy that cannot be answered by information available on NCI and NIH web pages are welcome to contact EGRP PDs for assistance. Those who do not already have an assigned PD are invited to review the EGRP staff list to identify PDs with related scientific interests.
Reserve Your Space in Our Upcoming Events!Webinars

TEAM webinar banner

New Mobile-Friendly Dietary Assessment Tool
July 19, 2016, 3:00-4:00 p.m. EDT

In this webinar, speakers from NCI (Amy Subar, Ph.D., M.P.H., R.D.) and Westat (Deirdre Douglass, M.S., R.D.; Amy Miller, M.P.H.; and Thea Zimmerman, M.S., R.D.) will describe the purpose and use of the latest mobile-friendly version of the Automated Self-administered 24-Hour Dietary Assessment Tool (ASA24), developed by NCI and Westat and freely available to researchers, clinicians, and educators for dietary intake collection. Speakers will describe the background of the tool, its evaluation, and best practices for its use.

For more information about this webinar and to register, visit the TEAM webinars page.
 
Up For a Challenge banner

Research Symposium Announcing 
Winners of NCI's U4C 
September 12, 2016, 1:00-4:00 p.m. EDT
NIH Campus, Building 35A, Room 610

In 2015, NCI and SAGE Bionetworks launched the "Up For A Challenge? (U4C) - Stimulating Innovation in Breast Cancer Genetic Epidemiology" competition to inspire novel cross-disciplinary approaches to more fully decipher the genomic basis of breast cancer.

Please join us in-person or via webinar for a research symposium at the NIH where the U4C winners will be announced and present their approach and results.

A draft agenda and more details can be found on the U4C website. Additional information about the webinar will be available soon for those unable to attend in person.

Banner for Conference on Geospatial Approaches to Cancer Control and Population Sciences September 12-14_ 2016 Natcher Conference Center_ NIH Campus

Conference on Geospatial Approaches to Cancer Control and Population Sciences
September 12-14, 2016
NIH Campus, Natcher Conference Center

The purpose of this conference is to bring together a community of researchers using geospatial tools, models, and approaches to address cancer prevention and control. It will address spatial and contextual aspects of cancer across the entire cancer control continuum including etiology, prevention, detection, diagnosis, treatment, and survivorship.

For more information and to register, visit the Conference website.

Infectious Agents webinars banner

Cutaneous Viral Infections as Potential Risk Factors for the Development of Non-Melanoma Skin Cancers

September 20, 2016, 11:30 a.m.-12:30 p.m. EDT

In this webinar, Dana Rollison, Ph.D. will discuss cutaneous viral infections as potential risk factors for the development of non-melanoma skin cancers.

Dr. Rollison is Vice President, Chief Health Information Officer at Moffitt Cancer Center. She is also the PI of the NCI-funded VIRUSCAN Study, a 5-year, prospective cohort study of cutaneous viral infections, UV exposure, and risk of basal and squamous cell carcinomas being conducted among skin cancer screening patients attending the University of South Florida Dermatology Clinic.

For more information and to register, visit the Infectious Agents and Cancer Epidemiology Research webinars web page.
Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute | 9609 Medical Center Drive | 4 East, MSC 9763 | Bethesda | MD 20892


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