National Cancer Institute
Epidemiology and Genomics Research
CANCER EPIDEMIOLOGY MATTERS E-NEWS
June 2015
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Turkey-US Collaborative Program for Affordable Medical Technologies (R01)
Application due dates: Standard dates apply
Expiration date: January 8, 2018

Assay Validation for High Quality Markers for NCI-Supported Clinical Trials (Admin Supp)
Application due dates: October 7, 2015; February 9, 2016; July 8, 2016; October 7, 2016; February 9, 2017; July 7, 2017; October 6, 2017; March 26, 2018; July 8, 2018
Expiration date: July 9, 2018

Diet and Physical Activity Assessment Methodology (R01)
Application due dates: October 5, 2015; June 5, 2016; February 5, 2017; October 5, 2017; June 5, 2018
Expiration date: September 8, 2018

Diet and Physical Activity Assessment Methodology (R21)
Application due dates: October 16, 2015; June 16, 2016; February 16, 2017; October 16, 2017; June 16, 2018
Expiration date: September 8, 2018
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August 13-14, 2015
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Bethesda, MD 
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About EGRPAboutEGRP
The Epidemiology and Genomics Research Program (EGRP) in the Division of Cancer Control and Population Sciences (DCCPS) funds research in human populations to understand the causes of cancer and related outcomes.

The Program fosters interdisciplinary collaborations, as well as the development and use of resources and technologies to advance cancer research and translation of this research, which serve as the basis for clinical and public health interventions.
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email: [email protected]
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The National Cancer Institute (NCI) established the Provocative Questions (PQ) Initiative in 2010 to support innovative research projects designed to solve specific problems and paradoxes in cancer research. Some of these PQs stem from intriguing but older, neglected observations that have never been adequately explored. Other PQs are built on more recent findings that are perplexing or paradoxical and reveal important gaps in current knowledge. Finally, some PQs reflect problems that traditionally were thought to be intractable but that now may be open to investigation using new strategies and recent technical advances.

 

The research community has assembled 12 PQs that vary by cancer research topic, and four of these may be of particular interest to population science researchers:

  • PQ-2: What molecular mechanisms influence disease penetrance in individuals who inherit a cancer susceptibility gene?
  • PQ-3: How do variations in tumor-associated immune responses contribute to differences in cancer risk, incidence, or progression?
  • PQ-9: What are the molecular and/or cellular mechanisms that underlie the development of cancer therapy-induced severe adverse sequelae?
  • PQ-12: What methods and approaches induce physicians and health systems to abandon ineffective interventions or discourage adoption of unproven interventions?

The other eight PQs can be viewed on the PQ Initiative's website.

 

The PQ Initiative uses the National Institutes of Health's (NIH) R01 and R21 Request for Applications (RFA) mechanisms to fund investigator-initiated projects that focus on addressing a particular PQ. Investigators can apply for R01 and R21 awards for each PQ (standard grant rules apply). The next application due dates for these mechanisms are October 29, 2015; June 29, 2016; and October 28, 2016. A Letter of Intent is due 30 days prior to the application due dates.


F
or questions or more information about the PQ Initiative, visit the Initiative's website or e-mail [email protected].

 

New Meta-Analysis Resource Helps Cancer Epidemiologists Grasp the State of the ScienceCGEN

Cancer-related clinical and population-based research has undergone rapid growth in the past two decades. Because navigating this growing body of literature can be overwhelming, scientists are increasingly relying on synthesized publications such as meta-analyses to evaluate the available evidence; help identify scientific gaps; and guide research, policy, and practice.  

The Cancer Genomics and Epidemiology Navigator (CGEN)-which allows users to search for grants, publications, genomic tests, and other resources relevant to cancer epidemiology-now offers a searchable database of meta-analyses of cancer clinical and population-based research published from 2008 to the present.

Number of meta-analyses by cancer site in the CGEN database as of June 2015

Researchers can use the database to identify useful information or perform analyses related to their scientific area of interest. For example, EGRP staff conducted analyses to provide an overview of selected characteristics of more than 4,000 publications currently in the CGEN Meta-Analysis Database. The findings showed a significant and steady increase in published meta-analyses from 2008 to 2013.   

In addition to being searchable by year, author, journal, and cancer site, the new Meta-Analysis Database also can be filtered by stage of cancer care continuum, study type, and selected study characteristics. As with all CGEN resources, the Meta-Analysis Database will be updated continuously to reflect recently published meta-analyses emerging from cancer epidemiology studies and cancer clinical trials.

EGRP's vision and hope is to provide the scientific community with an invaluable tool that will help users further develop their research interests. More information about CGEN's new meta-analysis search option can be found on the CGEN website. A more detailed description of CGEN's capabilities can be found in the August 2014 issue of this newsletter.

 

 
Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute | 9609 Medical Center Drive | 4 East, MSC 9763 | Bethesda | MD 20892


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