National Cancer Institute
Epidemiology and Genomics Research
CANCER EPIDEMIOLOGY MATTERS E-NEWS
September 2013

About Us 

Funding Opportunity
AnnouncementsFundingAnnouncements
NIH Transformative Research Awards (R01)
Application due date: October 4, 2013
Expires October 5, 2013

Creative and Novel Ideas in HIV Research
Sponsored by the International AIDS Society, the NIH, and NIH-funded Centers for AIDS Research
Concepts (2 pages) due: October 16, 2013
  
RFA-AG-14-003
Collaborative Research Infrastructure to Develop Research Strategies to Identify Potential Therapeutic Targets Based on Genetic Factors Influencing Human Life Span and Health Span (U24)
Application due date: November 4, 2013
Expires November 5, 2013

 

PA-13-276 

NLM Administrative Supplements for Informationist Services in NIH-Funded Research Projects

Application due date: November 5, 2013

Expires November 6, 2013   

 

NOT-OD-13-108

Small Business Innovation Research (SBIR) Program Contract Solicitation (PHS 2014-1) Now Available 

Contract proposal due date: November 13, 2013 

 

Research on the Role of Epigenetics in Social, Behavioral, Environmental, and Biological Relationships throughout the Life-Span and Across Generations (R21)
Application due date: November 13, 2013
Expires November 14, 2013
  
Genomics of Gene Regulation (U01)
Application due date: November 15, 2013
Expires November 16, 2013

RFA-HG-13-009
Centers of Excellence for Big Data Computing in the Biomedical Sciences (U54)
Application due date: November 20, 2013
Expires November 21, 2013

RFA-RM-13-012
NIH Health Care Systems Research Collaboratory- Demonstration Projects for Pragmatic Clinical Trials Focusing on Multiple Chronic Conditions (UH2/UH3)
Application due date: December 2, 2013
Expires December 3, 2013 

 

PAR-13-300
NLM Express Research Grants in Biomedical Informatics (R01)
Application due dates: Standard dates apply
Expires September 8, 2016


PA-13-288 (R21)
PA-13-292 (R01)
Behavioral and Social Science Research on Understanding and Reducing Health Disparities
Application due dates: Standard dates apply
Expires September 8, 2016
 

 

 

Grants Policy AnnouncementGrantsmanshipAnnouncements

PAR-13-321

The NCI P01 PAR has been reissued as PAR-13-321 so that P01 applications can be submitted electronically for the next receipt date deadline of September 25, 2013, and beyond.

Job OpportunitiesJobOpportunity
Program Director, Cancer Epidemiology Cohort and Consortia Coordination

Program Director, Clinical and Translational Epidemiology Branch

Cancer Research Training Award Fellow, Cancer Epidemiology Cohort and Consortia Coordination

Upcoming Seminars & WorkshopsEvents
Webinar: New Developments in the Tobacco Use Supplement to the Current Population Survey

September 17, 2013, 1:30-3:30 ET  

 

October 7-9, 2013 in Bethesda, MD
  
October, 16-17, 2013 in Cambridge, UK
  
October 19-23, 2013, in Boston, MA
  
October 28-30, 2013 in Sioux Falls, SD

Asia Cohort Consortium Fall Meeting 

November 11-12, 2013 in Tokyo, Japan
 

2013 Cohort Consortium Annual Meeting 

November 18-19, 2013 in Rockville, MD

About EGRPAboutEGRP
The Epidemiology and Genomics Research Program (EGRP), in the Division of Cancer Control and Population Sciences (DCCPS) funds research in human populations to understand the causes of cancer and related outcomes.

The Program fosters interdisciplinary collaborations, as well as the development and use of resources and technologies to advance cancer research and translation of this research, which serve as the basis for clinical and public health interventions.
Send Us Your IdeasSendUsYourIdeas
EGRP encourages readers to submit items of interest to Cancer Epidemiology Matters E-News. EGRP reserves the right to decide whether or not materials are appropriate for inclusion.
Contact UsContactUs
Epidemiology and Genomics Research Program
Division of Cancer Control and Population Sciences
National Cancer Institute
9609 Medical Center Drive
4 East, MSC 9763
Bethesda, MD  20892
(240) 276-6730
e-mail: nciepimatters@mail.nih.gov
website: epi.grants.cancer.gov
blog: blog-epi.grants.cancer.gov
Twitter: twitter.com/NCIEpi

For UPS, FedEx, and courier services, please use:
Rockville, MD  20850
NCI recently issued twenty new Provocative Questions (PQs) for 2014 on the NCI PQ website. The PQ Initiative invites proposals for bold new approaches to answer perplexing scientific questions identified by the research community.  The questions are grouped into five themes:
    1. How do decision making processes influence habitual behaviors, and how can that knowledge be used to design strategies that lead to adoption and maintenance of behaviors that reduce cancer risk?
       
    2. How does the level, type, or duration of physical activity influence cancer risk and prognosis?
       
    3. What biological mechanisms influence susceptibility to cancer risk factors at various stages of life?
       
    4. For tumors that arise from a pre-malignant field, what properties of cells in this field can be used to design strategies to inhibit the development of future tumors?
    1. Why do second, independent cancers occur at higher rates in patients who have survived a primary cancer than in a cancer-na´ve population?
       
    2. What molecular and cellular events in the tumor microenvironment (for example, the local immune response) determine if a tumor at the earliest stages of malignant transformation is eliminated, stimulated for further development, or made indolent?
       
    3. What mechanisms initiate or sustain cancer cachexia, and can we target them to extend lifespan and quality of life for cancer patients?
       
    4. What methods can be devised to characterize the functional state of individual cells within a solid tumor?
    1. What properties of pre-cancerous lesions or their microenvironment predict the likelihood of progression to malignant disease?
       
    2. What molecular or cellular events establish tumor dormancy after treatment and what leads to recurrence?
       
    3. How do variations in tumor-associated immune responses among patients from distinct well-defined populations, such as various racial/ethnic or age groups, contribute to differences in cancer outcomes?
       
    4. What in vivo imaging methods can be developed to portray the "cytotype" of a tumor - defined as the identity, quantity, and location of each of the different cell types that make up a tumor and its microenvironment?
    1. What molecular properties make some cancers curable with conventional chemotherapy?
       
    2. What features of standard-of-care therapies enhance or inhibit the efficacy of immunotherapy?
       
    3. Do tumors evolve common features that could act as new therapeutic targets when they metastasize to the same secondary site?
       
    4. What are the mechanistic bases for differences in cancer drug metabolism and toxicity at various stages of life?
    1. What strategies optimize adoption and sustainability of guideline concordant cancer treatments in community settings?
       
    2. What care delivery models can be developed to transition cancer patients effectively from active therapy to end of life care?
       
    3. What methods and approaches induce physicians and health systems to abandon ineffective interventions or discourage adoption of unproven interventions?
       
    4. What are the best methods to identify and stratify subgroups of patients with particular co-morbidities who will benefit from defined cancer therapies?

Although more details will be added to the PQ website in the coming weeks, including links to background information and the new Requests for Applications (RFAs), EGRP thought it would be helpful for investigators to see the new questions as early as possible.


Letters of intent are due December 16, 2013 and applications will be due January 15, 2014.


The contact for cancer epidemiology questions is Danielle Carrick, Ph.D., M.H.S.  The NCI contact is Emily Greenspan, Ph.D., Center for Strategic Scientific Initiatives. 
 

Got Cancer Genomics Data?cloudpilots
Help NCI's Cancer Genomics Cloud Pilots Program Understand Epidemiologists' Big Data Needs 
  
cloud computing
  
One of the eight recommendations stemming from the December 2012 workshop "Trends in 21st Century Epidemiology: From Scientific Discoveries to Population Health Impact," called for integration of big data into the practice of epidemiology. This recommendation was made based on the increasing urgency for researchers to harness the deluge of genomic, molecular, clinical, epidemiologic, environmental, and digital data needed to have a greater impact on medical and public health decision making. 
 
Traditionally, epidemiologists have been involved in the collection and analysis of large datasets, and should play a central role in directing financial resources and institutional/organizational investments to build infrastructures for the storage and analysis of large datasets.
 
NCI (and the biomedical community broadly) is investigating next generation computational capabilities to support researchers through its Cancer Genomics Cloud Pilots. In April 2013, NCI's Director Harold Varmus, M.D., invited grantees to provide input on the creation of public "cancer knowledge clouds," namely data repositories with co-located computational resources. Such clouds have the potential to increase the speed of discovery and democratize access to data. NCI plans to conduct a series of cloud pilots focusing on cancer genomics data that will lead to the development of a cancer knowledge cloud or clouds.
 
The National Cancer Informatics Program (NCIP) is now seeking input from the research community to review, comment, and vote on the types of scientific analyses the Cloud Pilots should address, as well as the priority datasets that should be accessible for analysis through them. To provide feedback, visit the Cancer Genomics Cloud Pilots IdeaScale site.
Where to Turn for Answers to Grants-Related QuestionsGrantsFAQ
New Grantsmanship Resources Available on EGRP's Website
  
time for answers
Image courtesy of Stuart Miles / FreeDigitalPhotos.net
EGRP's Program Directors provide a broad spectrum of grants-related information, advice, and consultation to scientists and institutional science management officials about NIH and NCI funding, scientific review policies, and procedures; preparation of grant applications; and funding instruments.

Our redesigned Website contains an expanded Grantsmanship Resources section that contains information relevant to:
  • New and Early Stage Investigators,
  • Projects involving Multiple Principle Investigators,  
  • Preparing, submitting, and tracking a grant application,
  • Peer review,  
  • Tools for reviewing NIH-supported projects,  
  • Award management and reporting, and
  • Grants policy resources. 

In addition to providing links to key NIH and NCI Web pages, EGRP's Grantsmanship Resources pages contain answers to questions frequently asked by investigators.

 

For any unanswered questions, investigators are encouraged to contact EGRP staff members.



Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute | 9609 Medical Center Drive | 4 East, MSC 9763 | Bethesda | MD 20892


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