CON A-Induced Hepatitis Model
in Mouse or Rat
Autoimmune Hepatitis (AIH) is a chronic inflammatory disease of the liver characterized by breakdown of self-tolerance leading to the appearance of autoantibodies (ANA, SMA, other). The Con A - induced hepatitis animal model is the most important AIH research model and plays a key role in AIH drug development.
ConA induced hepatitis is well established as an ideal animal model for study of T cell-mediated liver diseases, such as AIH and viral hepatitis.
WBI has validated models for hepatitis in both mouse and rat with extended readouts to provide comprehensive in vivo analysis of compound anti-inflammatory efficacy.
Concanavalin-A Induced Hepatitis Model
Species: Mouse or Rat
Groups:
- Vehicle
- One group for each dose of each test compound
Group Size: 10-15 animals
- 2 days for acute hepatitis
- 4 weeks for chronic hepatitis
Readouts: AST, ALT, TNF-α, IFN-γ, IL-17
Optional:
- Histopathology analysis of liver leukocytes infiltration
- Hepatic necrosis and liver fibrosis
- Other inflammatory cytokines
- ANA antibody response measured by IFA
CON A-Induced Mouse Model
The WBI mouse model for hepatitis provides comprehensive analysis through readouts of clinical chemistry markers, cytokines, autoantibodies and histopathology.
Serum levels of AST in CON A-Induced Hepatitis Rat Model
Serum levels of ALT in CON A-Induced Hepatitis Rat Model
Serum levels of Inflammatory Cytokines in CON A-Induced Hepatitis Rat Model
