In Vivo Services Update

                                             

In This Issue: CON A-Induced Hepatitis Model in Mouse or Rat
  
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Washington Biotechnology, Inc. 
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CON A-Induced Hepatitis Model

in Mouse or Rat

 

 

Autoimmune Hepatitis (AIH) is a chronic inflammatory disease of the liver characterized by breakdown of self-tolerance leading to the appearance of autoantibodies (ANA, SMA, other). The Con A - induced hepatitis animal model is the most important AIH research model and plays a key role in AIH drug development.

 

ConA induced hepatitis is well established as an ideal animal model for study of T cell-mediated liver diseases, such as AIH and viral hepatitis.

 

WBI has validated models for hepatitis in both mouse and rat with extended readouts to provide comprehensive in vivo analysis of compound anti-inflammatory efficacy.

 

 

Concanavalin-A Induced Hepatitis Model


 

Species:  Mouse or Rat

 

Groups:

  • Vehicle
  • One group for each dose of each                                   test compound

 

Group Size: 10-15 animals


Test Duration:   
  • 2 days for acute hepatitis
  • 4 weeks for chronic hepatitis

Readouts:  AST, ALT, TNF-α, IFN-γ, IL-17

 

Optional:

  • Histopathology analysis of liver leukocytes infiltration
  • Hepatic necrosis and liver fibrosis
  • Other inflammatory cytokines
  • ANA antibody response measured by IFA   

 

 

CON A-Induced Mouse Model

 

 

The WBI mouse model for hepatitis provides comprehensive analysis through readouts of clinical chemistry markers, cytokines, autoantibodies and histopathology.

 

 

 

 

 

 

 

 

 

 

 

 

 

 


CON A-Induced Rat Model 

 

 

Serum levels of AST in CON A-Induced Hepatitis Rat Model

 

 

 

Serum levels of ALT in CON A-Induced Hepatitis Rat Model

 

 

 

 

 

Serum levels of Inflammatory Cytokines in CON A-Induced Hepatitis Rat Model

 

 

 

 

 

 

 

 

 

 

 

 

 


For further information on this model; to discuss a study you are considering; or to request a Draft Protocol and Quotation please contact us.

 

 

 

Washington Biotechnology, Inc. (WBI)

 In Vivo CRO Partner of Choice

 Since 1988

 

 

WASHINGTON BIOTECHNOLOGY, INC. offers:

  • All services at our U.S. facility in Baltimore, Maryland
  • Competitive Pricing
  • Rapid start-up of studies
  • Fully detailed final reports
  • Standard or custom protocols 

Specialists in vaccine and compound testing with prophylactic or therapeutic protocols for:
  • Inflammation models
  • Arthritis models
  • Cancer - xenograft, orthotopic, syngeneic 
  • Bacterial infection models (antibiotic efficacy)  

Full in vitro support services:
  • Plasma, tissue, organ collections & preservations
  • Histology
  • Cytokine assays
  • Cell counts (total and differential)
  • Clinical chemistries

And for optimal dosing selection we offer:

  • MTD
  • PK
  • Toxicity - acute and chronic
  • Our staff recommendations for formulations, dosing routes and regimens

Please contact us for expert recommendations on your intended vaccine or drug in vivo studies. Thank you.

Washington Biotechnology, Inc.
6200 Seaforth Street
Baltimore, MD 21224
USA
TEL: +1-410-633-9210
FAX: +1-410-633-9213
  
  
General Enquiries:    wbio@washingtonbiotech.com