In Vivo Services Update

                                             

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IMQ Psoriasis Model
  
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Washington Biotechnology, Inc. 
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Innovation . Experience . Reliability . Speed 
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IMQ Psoriasis Model
 

 

Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders involved in the dysregulated interplay between immune cells and keratinocytes. Topical application of immiquimod (IMQ), a TLR 7/8 ligand and potent immune activator, on mouse skin can induce psoriasis.

  

IMQ-Induced psoriasis is a useful mouse model for evaluation of new therapies for psoriasis and dermatitis. Washington Biotechnology is pleased to offer this model.   
 

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IMQ-induced psoriasis Model in Balb/c mice

  

 

Study period: two weeks

  

Basic Read-outs: erythema, scaling, thickness of the back skin, and ear thickness

  

Optional:

Back skin and ear tissue histology (Epidermal thickening in back and ear skin, hyperproliferative keratinocytes, abnormal keratinocyte differentiation with marked parakeratosis).

  

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Comparison of erythema, scaling and thickness of the back skin with IMQ application and vaseline cream 

(as control) and prednisone treatment

  
  

 

 
  
 
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Comparison of thickness of ear with IMQ application and vaseline cream (as control), and prednisone treatment, and phenotypical presentation of mouse back skin and right ear     
 
 
 
 
 
 

 

  
For further information on this model and to receive expert recommendations on your intended study, please contact us.
Thank you. 
  
 

WASHINGTON BIOTECHNOLOGY, INC. offers:

  • All services at our U.S. facility in Baltimore, Maryland
  • Competitive Pricing
  • Rapid start-up of studies
  • Fully detailed final reports
  • Standard or custom protocols 

Specialists in vaccine and compound testing with prophylactic or therapeutic protocols for:
  • Inflammation models
  • Arthritis models
  • Cancer - xenograft, orthotopic, syngeneic 
  • Bacterial infection models (antibiotic efficacy)  

Full in vitro support services:
  • Plasma, tissue, organ collections & preservations
  • Histology
  • Cytokine assays
  • Cell counts (total and differential)
  • Clinical chemistries

And for optimal dosing selection we offer:

  • MTD
  • PK
  • Toxicity - acute and chronic
  • Our staff recommendations for formulations, dosing routes and regimens

Please contact us for expert recommendations on your intended vaccine or drug in vivo studies. Thank you.

Washington Biotechnology, Inc.
6200 Seaforth Street
Baltimore, MD 21224
USA
TEL: +1-410-633-9210
FAX: +1-410-633-9213
  
  
General Enquiries:    [email protected]