WASHINGTON BIOTECHNOLOGY, INC.

 

In Vivo Services Update

                                             
Quick Links
For information on all of our services, please visit
  
  
Rapid Turnaround  PK and MTD Studies in mice or rats; with or without quantitation.
  
- Start within 1 week of order 
- Dedicated Project Manager
- Detailed Report
  
WBI  in vivo  disease models include:
  

  
   Animal Models for Arthritis: Test in Two Species 

Prompt Start-up - Economical Pricing - Project Management - Full Reports

 

   

     Effective Rodent/Rabbit "Combo-Testing"

For

Additional Assurance of Test Material Efficacy

 

Animal models of rheumatoid arthritis are accepted as important screening tests for efficacy of test materials.

 

Because no single test is definitive in predicting efficacy for treatment of humans the importance of results from animal models in more than one species is recognized.

 

Our scientists have long experience in two important animal models for human rheumatoid arthritis: Collagen-Induced Arthritis in rodents and Ovalbumin-Induced Arthritis in rabbits.

 

The Collagen-Induced Arthritis (CIA) model in mice or rats is widely used as an important screen for test material efficacy.

 

The Ovalbumin-Induced Arthritis (OIA) in rabbits is an equally valuable in vivo model although not as widely available as the CIA models. Experience with intra-articular injections is an important requirement for success with this model.

 

Our services for these two models include:

 
  •         Long-established expertise in procedures and results analysis.
  •         Validated positive control (methotrexate, dexamethasone, EnbrelTM, AbataceptTM, other).
  •         Recommendations for dosing routes and formulations for test materials.
  •         Experience with compound, biologics and vaccine dosing.
  •         MTD, PK to determine optimal dosing.

 


   

Test results from both of these models are important to provide confirmatory assurance of test material efficacy.

 

Our CIA and OIA readouts include:

 

·        Disease model scoring/measurements by experienced staff

·        Weight monitoring and cage-side observations

·        Statistical analysis for efficacy

Optional items:

-         PK sampling

-         Clinical chemistries

-         Cells: CBC/diff

-         Histopathology

-         Cytokines

-         Tissue collections: e.g. lymph nodes for B-cell analysis (CIA); synovium tissue

-         Antigen titers: collagen/ovalbumin

 

 

OIA Rabbit Results:

 OIA rabbit_2 species_1

 

 OIA Rabbit_2 species 2

 

CIA Mouse Results:

 CIA Mouse

                                                           

 CIA Rat Results:

 

 CIA Rat                          

 

 

 

 

Please contact us for further information on our in vivo arthritis models. Thank you.

 

 

 

 

 

 

 

 

 

 

 
 

WASHINGTON BIOTECHNOLOGY, INC. offers:

  • All services at our U.S. facility in Baltimore, Maryland
  • Competitive Pricing
  • Rapid start-up of studies
  • Reports to FDA standards
  • Standard or custom protocols 

Specialists in vaccine and compound testing with prophylactic or therapeutic protocols for:
  • Inflammation models
  • Arthritis models
  • Cancer - xenograft, orthotopic, syngeneic 
  • Bacterial infection models (antibiotic efficacy)  

Full in vitro support services:
  • Plasma, tissue, organ collections & preservations
  • Histology
  • Cytokine assays
  • Cell counts (total and differential)
  • Clinical chemistries

And for optimal dosing selection we offer:

  • MTD
  • PK
  • Toxicity - acute and chronic
  • Our staff recommendations for formulations, dosing routes and regimens

Please contact us  for expert recommendations on your intended vaccine or drug
in vivo studies. Thank you.

Washington Biotechnology, Inc.
6200 Seaforth Street
Baltimore, MD 21224
USA
TEL: +1-410-633-9210
FAX: +1-410-633-9213
 Email (General Inquiries): wbio@washingtonbiotech.com