Cherry Consumption and the Risk of Recurrent Gout Attacks.
Six hundred and thirty three individuals with gout were followed for 1 year and asked to record the onset date of the gout attack, symptoms and signs, medications (including anti-gout medications), and potential risk factors (including daily intake of cherries and cherry extract) during the 2-day period prior to the gout attack. Cherry intake over a 2-day period was associated with a 35% lower risk of gout attacks compared to no intake. In those individuals consuming cherries 35 % ate them fresh, 2% ingested them as extract and 5% consumed cherry fruit and extract. A cherry serving was one half cup or 10-12 fruit. The gout flare risk continued to decease with increasing cherry consumption up to 3 servings over 3 days but more than that did not confer additional benefit. When cherry intake was combined with allopurinol use, the risk of gout attacks was 75% lower than periods without either exposure
Arthritis Rheum. 2012 Sep 28. [Epub ahead of print]
Cherry consumption and the risk of recurrent gout attacks.
Lactobacillus Plantarum CJLP133 for the Treatment of Atopic Dermatitis.
This randomized placebo controlled trial included 118 chiclren (12 months - 13 years) with atoptic dermatitis. The chiclred were given Lactobacillus plantarum CJLP133 at a dosage of 0.5 × 10(10) colony-forming units or placebo twice a day for 12 weeks. The mean change in the SCORAD score from weeks 2-14 was 9.1 in theprobiotic group and 1.8 in the control group. There were no statistical differences between the groups in total use of topical steroids. The probiotic group had a significantly lower total eosinophil count at the end of the intervention compared to baseline measurements. Logarithmic IFN-γ and IL-4 were also significantly decreased in the probiotic group.
Pediatr Allergy Immunol. 2012 Nov;23(7):667-73. Epub 2012 Oct 11.
A randomized trial of Lactobacillus plantarum CJLP133 for the treatment of atopic dermatitis.
Oral Magnesium Supplementation in Children with Cystic Fibrosis Improves Clinical and Functional Variables
Forty-four cystic fibrosis (CF) patients (aged 7-19 years; 20 males) were randomly assigned to receive magnesium 300 mg/day or placebo for 8 weeks with a 4 week washout period between trials. All patients were undergoing conventional treatment of CF. oth maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) significantly improved only after magnesium administration. A change in MIP of 11% was predicted after magnesium compared with 0.5% predicted after placebo; a change in MEP of 11.9% was predicted after magnesium compared with 0.8% predicted after placebo.
Am J Clin Nutr. 2012 Jul;96(1):50-6. Epub 2012 May 30.
Oral magnesium supplementation in children with cystic fibrosis improves clinical and functional variables: a double-blind, randomized, placebo-controlled crossover trial.
Advantages of the Association of Resveratrol with Oral Contraceptives for Management of Endometriosis-related Pain.
Twelve patients who failed to obtain relief from endometriosis-related pain during use of an oral contraceptive containing drospirenone + ethinylestradiol were given 30 mg of resveratrol in addition to the contraceptive regimen for 2 months. At the end of 2 months 82% of the patients reported complete resolution of dysmenorrhea and pelvic pain. In a separate experiment, aromatase and cyclo-oxygenase-2 expression were investigated in the endometrial tissue of 42 patients submitted to laparoscopy and hysteroscopy for the management of endometriosis. Sixteen of these patients were using oral contraceptives alone prior to hospital admission, while the remaining 26 were using them in combination with resveratrol. Inhibition of both aromatase and cyclo-oxygenase-2 expression was significantly greater in the eutopic endometrium of patients using combined drospirenone + resveratrol therapy compared with the endometrium of patients using oral contraceptives alone.
Int J Womens Health. 2012;4:543-9. Epub 2012 Oct 10
Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain.
Is a Multispecies Probiotic Mixture Effective in Constipation During Pregnancy?
Twenty pregnant women with functional constipation received a daily dose of Ecologic(R)Relief (Bifidobacterium bifidum W23, Bifidobacterium lactis W52, Bifidobacterium longum W108, Lactobacillus casei W79, Lactobacillus plantarum W62 and Lactobacillus rhamnosus W71 (total 4*109 CFU)) for 4 weeks in this pilot study. At week 4 defecation frequency significantly increased from 3.1 at baseline to 6.7 in week four. Compared to baseline, there was a significant decrease in 1) sensation of anorectal obstruction from 90.0% to 45.0% 2) sensation of incomplete evacuation from 90.0% to 40.0%, 3) straining during defecation from 100% to 65%, 4) episodes of abdominal pain from 60% to 20% and 5) the presence of reflux episodes from 60% to 20% in week four.
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Nutr J. 2012 Oct 4;11(1):80. [Epub ahead of print]
Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'
Maternal Probiotic Supplementation During Pregnancy and Breast-feeding Reduces the Risk of Eczema in the Infant.
Two hundred and forty one mothers (with allergic disease and atopic sensitization)-infant pairs were randomly assigned to receive Lactobacillus rhamnosus LPR and Bifidobacterium longum BL999 (LPR+BL999), or L paracasei ST11 and B longum BL999 (ST11+BL999), or placebo, beginning 2 months before delivery and during the first 2 months of breast-feeding. The infants were followed until the age of 24 months. Skin prick tests were performed at the ages of 6, 12, and 24 months. The risk of developing eczema during the first 24 months of life was significantly reduced in infants of mothers receiving LPR+BL999 and ST11+BL999. The respective odd ratios for chronically persistent eczema were 0.30 and 0.17. Probiotics had no effect on the risk of atopic sensitization in the infants.
J Allergy Clin Immunol. 2012 Oct 16. [Epub ahead of print]
Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant.
Docosahexaenoic Acid (DHA) for Reading, Cognition and Behavior in Children Aged 7-9 Years
Three hundred and sixy-two healthy children (7-9 years) who were under performing in reading were randomly assigned to 600 mg/day DHA (from algal oil) delivered in three 500 mg capsules per day, each providing 200 mg DHA or placebo for 16 weeks. Significant effects were seen in the subgroup of 224 children whose initial reading performance was ≤20(th) centime. Parent-rated behavior problems (ADHD-type symptoms) were significantly reduced by active treatment, but little or no effects were seen for either teacher-rated behaviour or working memory.
PLoS One. 2012;7(9):e43909. Epub 2012 Sep 6.
Docosahexaenoic Acid for Reading, Cognition and Behavior in Children Aged 7-9 Years: A Randomized, Controlled Trial (The DOLAB Study).
Cholesterol-lowering Efficacy of Lactobacillus Plantarum in Hypercholesterolaemic Adults.
Sixty hypercholesterolaemic volunteers (18-65 years) were randomly given one capsule daily containing 1·2 × 109 colony-forming units of Lactobacillus strains or placebo for 12 weeks. A significant reduction of 13·6 % in plasma total cholesterol (TC) levels was observed after 12 weeks of consumption in the L. plantarum group when compared with the placebo group. Low initial values (LIV, 2000-2500 mg/l) v. high initial values (HIV, 2510-3000 mg/l) or total cholesterol were analysed. The present results showed that L. plantarum had a better effect in patients with higher levels of cholesterol.
Br J Nutr. 2012 Sep 28:1-7. [Epub ahead of print]
Cholesterol-lowering efficacy of Lactobacillus plantarum CECT 7527, 7528 and 7529 in hypercholesterolaemic adults.
The Effect of Black Currant Anthocyanins on Visual Field in Glaucoma.
Thirty-eight patients with open-angle glaucoma (OAG) were randomly assuaged to black currant anthocyanins (BCACs) or placebo for 24 months. There was a statistically significant difference in the mean change from baseline in the Humphrey visual field mean deviation (MD), the ocular blood flow increased in the BCAC group compared to the placebo group. There were no significant changes observed in systemic and ocular conditions including intraocular pressure (IOP). Oral administration of BCACs may be a safe and promising supplement for patients with OAG in addition to antiglaucoma medication.
Ophthalmologica. 2012;228(1):26-35. Epub 2012 Feb 22.
Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma.
Lactobacillus reuteri DSM 17938 for the Management of Infantile Colic in Breastfed Infants
Eighty infants aged < 5 months with infantile colic* who were exclusively or predominantly (>50%) breastfed were randomly assigned to receive L reuteri DSM 17938 (10(8) colony-forming units 5 drops, 1 time daily or placebo for 21 days. The rate of responders was significantly higher in the probiotic group compared with the placebo group at day 7, day 14, day 21 and at day 28. Throughout the study period median crying time was significantly reduced in the probiotic group compared to the control group.
* crying episodes lasting 3 or more hours per day and occurring at least 3 days per week within 7 days prior to enrollment
J Pediatr. 2012 Sep 14. [Epub ahead of print]
Lactobacillus reuteri DSM 17938 for the Management of Infantile Colic in Breastfed Infants: A Randomized, Double-Blind, Placebo-Controlled
Effect of Anti-inflammatory Supplementation with Whey Peptide and Exercise Therapy in Patients with COPD.
Thirty-six elderly stable COPD patients were randomly assigned to a whey peptide nutritional supplement or a placebo in addition to low-intensity exercise therapy. The nutritional supplement was a whey peptide with anti-inflammatory and anti-oxidant effects, n-3 fatty acids, vitamin A, C and E enriched. The nutritional support group had a significant increase in body weight, %IBW, FM, energy intake, %AC, Alb, PImax, PEmax, 6MWD, WBI, emotional function, and CRQ and the levels of hsCRP, IL-6, IL-8, and TNF-α were reduced significantly. There was no significant change noted noted in the control group.
Respir Med. 2012 Nov;106(11):1526-34.
Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD.
Efficacy of Omega-3 fatty Acid Supplementation on Serum levels of Tumour Necrosis Factor-alpha, C-reactive Protein and Interleukin-2 in Type 2 Diabetes Mellitus Patients.
Eighty-four subjects aged 45-85 years with at least a two-year history of type 2 diabetes mellitus either received three omega-3 capsules per day (eicosapentaenoic acid 1,548 mg; docosahexaenoic acid 828 mg; other omega-3 fatty acids 338 mg) or placebo (sunflower oil 2,100 mg) for eight weeks. Serum IL-2 and TNF-α levels were significantly reduced in the treatment group compared to the controls however there was no significant change in serum CRP levels.
Singapore Med J. 2012 Sep;53(9):615-9.
Efficacy of omega-3 fatty acid supplementation on serum levels of tumour necrosis factor-alpha, C-reactive protein and interleukin-2 in type 2 diabetes mellitus patients.
Antioxidant Supplement and Long-term Reduction of Recurrent Adenomas of the Large Bowel
Three-hundred and thirty patients who underwent polypectomy completed this study comparing antioxidant supplementation to placebo for 5 years and increased risk of adenoma recurrence. The antioxidant contained 200 μg selenium, 30 mg zinc, 2 mg vitamin A, 180 mg vitamin C, 30 mg vitamin E daily. At a median follow-up of 4 years 100 patients had recurrence: 38 in the intervention and 62 in the placebo arm. The 15-year cumulative incidence of recurrence was 48.3 % in the intervention and 64.5 % in the placebo arm. A 39 % reduction of the risk of recurrence was observed in the intervention compared to the placebo group the risk reduction was similar for small tubular and advanced adenomas.
J Gastroenterol. 2012 Oct 13. [Epub ahead of print]
Antioxidant supplement and long-term reduction of recurrent adenomas of the large bowel. A double-blind randomized trial.
Propionyl-L-carnitine Hydrochloride for Treatment of Mild to Moderate Colonic Inflammatory bowel Diseases.
Fourteen patents with mild to moderate ulcerative colitis (UC) or Crohn's disease (CD) colitis, with disease activity index (DAI) between 3 and 10 and under stable therapy with oral aminosalicylates, mercaptopurine or azathioprine, for at least 8 wk prior to baseline were given 2 g a day of Propionyl-L-carnitine. After treatment 71% of patients achieved response and 64% obtained remission. The reponse once was higher for CD (100%) with 75% achieving remission then UC (60%) after therapy. The median DAI of 7 decreased to 2 after treatment. Only patients with UC showed a significant reduction of DAI, from a median 6.5 to 2 after treatment. In CD patients the differences in DAI reduction were not significant. Seventy-nine percent of patients showed improvement of HI of at least 1 point, while only one CD and two UC patients showed HI stability; none showed HI worsening.
World J Gastroenterol. 2012 Sep 28;18(36):5065-71.
Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases.
Pycnogenol® improvements in asthma management.
Seventy-six patents with allergic (dust mite) asthma in controlled conditions were randomly assigned Pycnogenol® 50mg bid and or inhaled corticosteroid or inha;ed corticosteroid alone for 6 months. An individual patient's asthma condition was graded in five steps based on the daily dosage of inhaled fluticasone propionate with step 1 indicating 0 µg and step 5 the maximum dose of 500 µg ICS twice daily. Fifty-five percent of the Pycnogenol group passed to a lower inhaled corticosteroid dose compared to only 6% in the inhaled corticosteroid alone group. In the Pycnogenol there was no passing to a higher inhaled corticosteroid dose, where as in the inhaled corticosteroid group 18.8% required a higher dose. No serious adverse events were observed in both groups and tolerability of Pycnogenol® was very good. In the Pycnogenol group, night-awakenings were less frequent, the number of days with PEF<80% were decreased, days with asthma score >1 were lower, requirement for salbutamol and additional asthma medication less frequent, and consultation of general practitioner and specialist required less commonly.
Panminerva Med. 2011 Sep;53(3 Suppl 1):57-64.
Pycnogenol® improvements in asthma management.
Effect of Lactobacillus rhamnosus LGG® and Bifidobacterium animalis ssp. lactis BB-12® on Health-related Quality of Life in College Students Affected by Upper Respiratory Infections.
Two hundred and thirty one healthy college students living on campus were randomly assigned to receive placebo or probtiotic (daily dose of minimum 1 billion cfu of each Lactobacillus rhamnosus LGG® and Bifidobacterium animalis ssp. lactis BB-12®) for 12 weeks. The median duration of upper respiratory infection was shorter by 2 days and the severity score was significantly lower by 34% with probtiocs versus placebo. The number of missed days of work was similar in both groups but the number of missed school days was lower in the probiotic group.
Br J Nutr. 2012 Oct 1:1-9. [Epub ahead of print]
Effect of Lactobacillus rhamnosus LGG® and Bifidobacterium animalis ssp. lactis BB-12® on health-related quality of life in college students affected by upper respiratory infections.
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