Medical marijuana has been touted recently as a potential solution to the opioid epidemic and the prescription drug overdose dilemma facing our nation; that much is true. The concept is an interesting one; however, as it now stands, we do not have a lot of reliable evidence that can support this idea. Many legal and regulatory issues surround this topic, as do clinical implications related to patient safety, long-term outcomes, proven benefit (i.e., head-to-head clinical trials), etc. I certainly believe this is a topic worth exploring, but I also recognize there are several hurdles in existence today that may hamper any true, clinically sound arguments one way or the other.