Pain is the body's signal that something is wrong, right? What about pain that persists−sometimes long after the original injury has healed? Chronic pain is a scourge, not only for the afflicted, but also for employers and insurers who foot the bill. It drives costs, diminishes productivity and erodes quality of life. Strategies proposed to date chip away at various aspects of the problem. The next step in the evolution of treatment for chronic pain must be a holistic solution that addresses the complexity of the issue.