Treating Diabetic Macular Edema

Treatment for diabetic macular edema has never been better! We now have various ways to reverse vision loss from this common complication of diabetic retinopathy. When I started as a retinal specialist in 1993, treatment for diabetic macular edema was limited to laser treatment. Either "focal" treatment to leaky microaneurysms or "grid" treatment was acceptable. Not every patient with clinically significant macular edema (CSME) was a candidate for laser treatment. For instance, those patients with microaneurysms located in the central macula could not be treated. But that's all we had. Even so, results were often disappointing
Anti-VEGF for Diabetic Macular Edema
You know that anti-VEGF injections (Macugen, Lucentis, Avastin, Eylea) have revolutionized the way wet ARMD can be treated, and these same intravitreal injections are now integral to the treatment of DME as well. In many cases where laser may not work or has not worked, anti-VEGF may be used to improve the macular edema and, usually, improve vision. In certain cases, anti-VEGF may be the first choice of treatment
Intra-ocular Steroids
Intraocular steroids have long been known to improve diabetic macular edema. In the 1990's, intravitreal injections of Kenalog emerged as an alternative to laser. Kenalog had two issues to overcome; 1) increase in intraocular pressure was common and, 2) intraocular injections were not commonplace in the 1990s.
Sustained Release Steroids
Ozurdex, a sustained release intraocular steroid (dexamethasone), is now FDA approved for the treatment of diabetic macular edema. It is delivered as an injection just as anti-VEGF agents are delivered. The implant will release steroid for about 4 months and then the vehicle will absorb. The results have been outstanding as often both the macular edema and vision improves.
Advantages to patient treatment include; 1) Fewer office visits 2) No need for repeated anti-VEGF treatments 3) Ozurdex may work where previous treatments have failed 4) The polymer (transport device) is bioabsorbable.
Iluvien, a similar product, has also been FDA approved for DME. This product differs in that;1) The active drug is fluocinolone 2)The drug may last 3 years 3) Transport device does NOT absorb 4) IOP may be a concern as with all steroids
What Does This Mean??
Having treatment options allows us to treat a larger variety of patients. Laser treatment is no longer the gold standard. "Standard of Care" now includes intravitreal injections of anti-VEGF, steroids and sustained released steroids. Treatments are also more successful. Previously, the goal of laser treatment was to prevent further vision loss. It is usual to now expect the vision to improve. In addition, with the variety of treatment options, it is clear that diabetic macular edema is the result of a complex pathway involving mediators of vascular permeability (VEGF) and inflammation. If you've got questions or comments, please email me or visit my blog
Randy
randall.v.wong@gmail.com
www.retinaeyedoctor.com
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