Research News
MEDICAL SCHOOL OFFICE OF RESEARCH
May 2015
EVENTS 

Guest Presentation: Learning to Love

De-identification in Biomedical Research

Monday, May 11

12:00 PM - 1:00 PM

Forum Hall,

Palmer Commons

 

Please RSVP for this event.

 

 

W.M. Keck Foundation Information Session

Tuesday, May 12

10:00 AM - 11:00 AM

Boardroom 5,

Palmer Commons

 

 

Come on BAIBA

Light My Fire:

Mining the Blood for New Cardiometabolic Hormones

Thursday, May 14

12:00 PM - 1:00 PM

Cure Room (5050),

Brehm Tower

 

 

Faculty Scholars Grant Competition Information Session #2

Monday, May 18

1:30 PM - 2:30 PM

Boardroom 5,

Palmer Commons

 

 

Preparing for Your Professional Career: What is Your Brand?

Wednesday, May 20

9:00 AM - 3:00 PM

Room D,

Michigan League

 

Registration is FREE, but space is limited. Please RSVP by Friday, May 15.

 

This event is co-sponsored by the Rackham Graduate School and the UMMS Office of Postdoctoral Studies. 

 

 

14th Annual

Life Sciences

Institute Symposium:

"Defense Mechanisms in Life: From Bacteria

to the Human Body"

Thursday, May 21

8:30 AM - 5:00 PM

Forum Hall,

Palmer Commons

 

This event is FREE and open to the public.

 

 

Data Interpretation in Quantitative Proteomics

Thursday, May 21

1:30 PM - 3:30 PM

Room 4515, BSRB

 

 

Early Tech

Friday, May 29 -

Friday, June 26

Four-week course

Rooms G063 & G064,

NCRC Building 10

 

 

Wednesday, June 10

Two sessions:

8:00 AM - 10:00 AM or

12:00 PM - 2:00 PM

BSRB Seminar Rooms

 

 

Fourth Annual

BRCF Technology

& Services Showcase

Thursday, June 11

11:30 AM - 2:00 PM

Great Lakes Room

and Forum Hall, 4th Floor,

Palmer Commons

 

 

Cancer Center Director Town Hall Meeting

Thursday, June 11

11:30 AM - 12:30 PM

Research Auditorium,

NCRC Building 10

 

 

Metabolomics MRC2 Summer Workshop

Monday, June 15 - Thursday, June 18

Kellogg Auditorium, Kellogg Eye Center

 

For more information, please contact Terri Ridenour via email or phone at (734) 647-7449.

 

 

Researchpalooza

Thursday, August 20

11:00 AM - 2:00 PM

Circle Drive in front of Med Sci I

 

 

CALL FOR POSTERS: Quality Month 2015
"Get to the Root Cause"

Tuesday, October 6 - Wednesday, October 7

 

Submit your poster for UMHHS Quality Month by the early decision date: Saturday, May 30. All posters must be received by the final Wednesday, July 1 deadline.

 

Click here for

submission instructions.

 

 

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& Hot Topics

Find UMHS facts and figures for your next proposal!

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MBECT Resources 

 

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of Research

 

U-M Medical School

 

UMMS
Competition Space

 

IN THIS ISSUE 
 
Leadership 
  • Funding
  • Policies
  • Training & Professional Development
  • Announcements
  • FundingOpps
    Select Research Funding &
    Award Opportunities
    External Limited Submissions
    AwardDeadline
    Monday, June 8
    W.M. Keck Science & Engineering
    and Medical Research Programs
    Monday, June 15


    Other Opportunities

    For additional information, we encourage you to visit the UMMS Office of Research Funding Opportunities page
    Lab.Safety
    President Schlissel Announces University-wide Effort to Enhance Laboratory Research Safety Culture
    The University of Michigan is launching an effort to enhance the culture of safety in research laboratories across the university.

    As part of an ambitious plan moving forward, U-M's Department of Occupational Safety and Environmental Health (OSEH) and Office of Research (UMOR), in coordination with the Office of the Provost, have launched an initiative to strengthen current programs for research safety.

    Practicing, promoting, and educating a strong culture of research safety is the foundation toward the goals of this initiative. The University recognizes that improvement begins and ends with your commitment as a member of the U-M Medical School departments, centers, institutes, and programs. OSEH and UMOR are ready to partner with our research community to identify your unique risks and find ways to deal with them.

    As part of this initiative, we have established:
    • A new oversight committee on research safety
    • A survey to assess awareness of safety procedures
    • Clarification of roles and responsibilities for laboratory safety, and
    • Increased communication and information on safety
      issues and procedures.
    We are proud of the opportunity to continue to improve U-M's strong commitment to the highest research standards, and are equally committed to the health and welfare of our faculty, staff, students, and community.

    For all of us, quality research is safe research.

    "Safe research is the responsibility of everyone
    in the laboratory -- how we think, how we act,
    and most of all understanding that making sure no one gets hurt in the process is paramount."
    - President Mark Schlissel

    Click here to view the full letter issued by President Schlissel addressing enhancements to the culture of safety at U-M.
    BRCF.Showcase
    Discover Technologies to Advance Your Research at the BRCF Technology & Services Showcase
    Thursday, June 11 at Palmer Commons

    Join the Biomedical Research Core Facilities (BRCF) for the fourth-annual Technology & Services Showcase as the Cores and their partner vendors highlight the latest advancements and equipment offerings in biomedical research.

     

    Thursday, June 11

    11:30 AM - 2:00 PM

    Great Lakes Room and Forum Hall
     4th Floor, Palmer Commons

    FREE lunch from Zingerman's

    (with entry ticket)

     

    RSVP for this FREE event:

    tiny.cc/brcfshowcase

     

    Speaking sessions featuring top experts in research will be held in Forum Hall, across the hall from the vendor area, including:

     

    10:30 AM:
    "An Introduction to Epigenetic Regulation: What Each of the Services can do for Your Research"
    by Maria "Ken" Figueroa, M.D., Epigenomics Core Director, Assistant Professor of Pathology
    1:30 PM:
    "Comparative Analysis of Custom
    Targeted Sequencing Panels"
    by Jeanne Geskes, Assistant Director of Core Technology, DNA Sequencing Core & Peter Ulintz, Bioinformatics Senior Development Analyst, Bioinformatics Core. They will cover panels from Agilent, Illumina, Nimblegen, Nugen, and Qiagen.

     

    For more information on participating units and vendors, please visit the event website.

    AAALAC.Visit
    AAALAC Site Visit 2015 --
    Dates Are Set!

    On Monday, June 22 (7 weeks from now) the University of Michigan will have the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) conduct a site visit of our animal research program.

     

    U-M will host eight site visitors for the full week; they will visit all housing locations on every campus and many laboratories. AAALAC accreditation is an important check to assure we have high standards for animal care and use, and is instrumental for building research collaborations and for seeking funding.

     

    The site visit is an important opportunity to prove our commitment to responsible conduct of animal research.

     

    The Animal Care and Use Program needs your help
    to prepare and with the conduct of the site visit.

    We will be sharing additional information with you
    over the next few weeks and have established
    the following website as a resource:
    www.ucuca.umich.edu/update.htm

     

    You will be invited to opportunities for in-person "Meetings for Action: AAALAC" hosted around campus where we hope laboratory staff working with animals will come to build upon knowledge to assist in answering questions from our AAALAC site visit team.

     

    We appreciate all of the efforts by our faculty and staff thus far; please help us spread the word to our U-M research community.

    Researchpalooza
    Researchpalooza 2015
    Save the date to connect with the labs and offices here to serve YOU!
    Join the UMMS Office of Research for Researchpalooza during the annual Ice Cream Social on Thursday, August 20 from 11:00 AM - 2:00 PM, with 50+ exhibitors from labs and offices of the Medical School and across campus.

    Located in the Circle Drive area near Med Sci I, there will be ice cream, popcorn, games, and fantastic prizes. 

    Researchpalooza 2015
    Thursday, August 20
    11:00 AM - 2:00 PM
    Circle Drive in front of Med Sci I

    Researchpalooza is the perfect opportunity for colleagues and friends to have a great time and meet, mingle, and learn more about many of the organizations that offer their stellar services to faculty, students, and staff, all at one convenient time and location.

    CLICK HERE to view an updated list of the exhibiting labs and offices. If your U-M office or lab is interested in hosting a table, sign up HERE.

    Hope to see you there!
    Vilcek
    Vilcek Foundation Announces
    2016 Vilcek Prizes for Creative Promise in Biomedical Science
    Applications due Monday, June 15
    The Vilcek Foundation,
    a nonprofit organization that honors and supports foreign-born scientists who have made an outstanding contribution to American society, is currently seeking applications for their 2016 Vilcek Prizes for Creative Promise in Biomedical Science.

    The Foundation will award three unrestricted cash prizes of $50,000 each to young (age 38 and under), foreign-born biomedical scientists who demonstrate outstanding early achievement. Eligible work may be in basic, applied, and/or translational biomedical science.

    Award winners will be notified by November 2015 and will be honored at an awards ceremony in New York City in April 2016.

    For more information, including application requirements, please visit the Vilcek Foundation website.

    Applications are due by 5:00 PM on Monday, June 15.

    Questions about this opportunity should be directed to Joe Piffaretti, UMHS Corporate and Foundation Relations, via email
    or phone at (404) 421-2012.
    IDEs
    Investigational Device Exemption Studies Now Reviewed, Approved Centrally by CMS
    New process affects all new studies submitted after January 1, 2015

    The Medicare Prescription Drug, Improvement, and Modernization Act of 2003 allowed Medicare payment of the routine costs of care furnished to Medicare beneficiaries in certain categories of Investigational Device Exemption (IDE) studies.

     

    As of January 1, 2015, the Center for Medicare & Medicaid Services (CMS) made changes to the process of obtaining coverage approval for standard of care items and services in a device trial. Previously handled by local Medicare Administrative Contractors (MACs), this process is now managed centrally by CMS.

     

    Investigators should note the following changes as a result of this new process:

    • Study teams submitting IDE studies for approval AFTER January 1, 2015 must now go through the central CMS office to obtain CMS Approval Letters. Detailed submission requirements are available here.
    • IDE studies approved by MACs PRIOR to January 1, 2015 will continue to be administered by the MAC. Study sponsors should continue to follow the process established by the MAC for any site additions or protocol changes.
    • Study sponsors do NOT have to submit their protocol to CMS if the participating study investigator sites have already received approval from their MAC.
    • CMS will post information on their website each week for IDE studies approved after January 1, 2015. Study teams are encouraged to check the CMS website to see if their site has already been approved prior to submitting a new application.

    To speed up the submission process, CMS has released a Checklist and Sample CrosswalkSubmitters are encouraged to submit the crosswalk along with the request packet to facilitate CMS' review. CMS will review each complete submission within approximately 30 days, and e-submissions (emails and/or electronic documents) are preferred over hardcopies.

     

    Questions?

    Please contact the Clinical Research Calendar Review & Analysis Office via email or phone at (734) 998-6880, or visit the CMS website for more information. 

    Rachel.Upjohn
    Proposals Sought for Rachel Upjohn Clinical Scholars Award
    Proposals due Monday, June 1

    The University of Michigan Depression Center is requesting proposals for the 2015 Rachel Upjohn Clinical Scholars Award Program.

     

    The purpose of this program is to support early career faculty at the

    U-M who are members of the Depression Center and are interested in engaging in clinical research on mood disorders.

     

    2015 Rachel Upjohn Clinical Scholars Award Program

    Proposal Deadline:
    Monday, June 1
    Research Focus:

    The Rachel Upjohn Clinical Scholars Award supports research in the etiology and treatments of depression, bipolar, and related disorders that will impact future care. 

     

    This includes a wide range of themes such as the biological, sociological, and psychological aspects of these illnesses.

    Eligibility:

    This opportunity is available to early career faculty members including research faculty, lecturers, or any rank up to Assistant Professor who are members of the Depression Center.

     

    Those who are not currently members can review criteria for membership here.

    Award Amount:

    Annual award of $50,000.*

    *Funding is contingent on IRB approval  

    Project Duration:
    Award period is two years.
    Number of Potential Awardees:
    One


    Additional details, including proposal guidelines, are available here. Proposals should be submitted electronically via UMMS Competition Space.

     

    Questions?

    Please contact Kim Weber in the Depression Center via email with questions about the application process.

    IVAC.Digital.Pathology
    IVAC Leaps Forward with Digital Pathology
    IVAC technicians Wendy Rosebury-Smith and Florin Timpau create a scanned image of a soft tissue tumor on an H&E stained slide.

    The In-Vivo Animal Core (IVAC), part of the Unit for Laboratory Animal Medicine (ULAM), recently acquired an Aperio AT2 high volume, digital whole slide scanner. The Aperio has the ability to perform precise slide digital capture and analysis, and will be used by IVAC to support research staff in their animal research studies.

     

    The scanned images are captured as eSlides, which may be shared with the requestor quickly and efficiently. In turn, the requestor may capture their own image for publication or choose to simultaneously view images with others. This ability is invaluable for investigators who collaborate globally.

     

    "Our investigators will have immediate access to collaborate with colleagues around the world and have improved decision-support tools, [increased] efficiency, and assistance in the drug development process," explains IVAC Manager Carrie Schray.
    "We also have the ability to create an IVAC digital slide library for veterinary pathology teaching and training purposes." 

     

    The scanner utilizes software algorithms to vary image magnification from less than 2x to as much as 40x. This feature shortens the time spent by IVAC's in-house pathologists, choosing a region for the photo or the best representation of a sample section, so that the veterinary pathologist may focus their expertise and trained eyes on analysis and interpretation. 

     

    The Aperio has high-capacity for slide capture and up to 400 slides may be scanned at a time. IVAC recommends that investigators submit samples in batches to take advantage of the scanner's capacity.

    To request information, contact IVAC via email or phone at
    (734) 647-0731, or visit the ULAM-IVAC website.

    Data.Sharing.Agreements
    Sharing UMHS Patient Data with External Collaborators?
    Simplified Process for Data Sharing Agreements

    To assure privacy and security when sharing patient-level data

    or specimens with a collaborator external to the University of Michigan, a Data Sharing Agreement (DSA) may be required.

     

    The DSA process has been greatly simplified: Log in to the eResearch Proposal Management System and create an Unfunded Agreement (UFA).

     

    When a UFA is submitted, the appropriate office will determine whether a DSA is required for your project and you will be provided the appropriate documentation and next steps to finalize your agreement. These activities take place within the UFA system.

     

    Visit the Honest Broker Office website for more information. 

    Discovery.Fund
    Discovery Fund Awardees Announced
    Six high-risk, interdisciplinary projects funded
    Earlier this year, the Medical School (UMMS) Office of Research accepted proposals for the Discovery Fund, which is supported by the proceeds from the 2014 Discovery Ball and part of the larger Medicine Needs Victors campaign.

    The Discovery Fund seeks to support investigator-initiated, bold and innovative science in areas that cross the basic to clinical research continuum. The RFP called for interdisciplinary teams led by early-stage investigators who are collaborating with more established investigators on new projects that can impact the research pipeline, driving bench science into the clinic to ultimately impact human health.

    The UMMS Office of Research recently announced the six Discovery Fund projects, funded up to $150,000 each: 
    • The role of intrinsically disordered regions of the diabetes gene CLEC16A in pancreatic-cell mitophagy 
      Scott Soleimanpour, M.D. & Santiago Schnell, Ph.D.
    • Steroid hormone profiling -
      a new strategy for diagnosis of adrenal tumors

      Tobias Else, M.D. & William Rainey, Ph.D.
    • Unconventional translation in neuronal function
      and eurologic disease
       
      Peter Todd, M.D., Ph.D. & Michael Sutton, Ph.D.
    • Improving prediction of acute myelogenous leukemia relapse through experimental and computational optimization of deep sequencing-based minimal residual disease detection 
      James Cavalcoli, Ph.D. & Sami Malek, M.D.
    • Influenza transmission in a vaccinated cohort 
      Adam Lauring, M.D., Ph.D. & Pat Schloss, Ph.D.
    • Regulation of hematopoietic stem cell quiescence
      by the gut microbiota
       
      Daniel Lucas-Alcaraz, Ph.D. & Gabriel Nunez, M.D.
    Metabolomics.Workshop
    Learn How to Expand Your Research Using Metabolomics
    Register for the Metabolomics Summer Workshop
    Join the Michigan Regional Comprehensive Metabolomics Resource Core (MRC2) this June as they explore primary concepts in metabolomics, data processing, and statistical analysis:


    Metabolomics Summer Workshop
    Monday, June 15 - Thursday, June 18
    Kellogg Eye Center

    After attending this four-day workshop, you'll be able to:
    • Identify and describe the primary concepts related
      to getting good results from metabolomics
    • Recognize and know how to address metabolomics opportunities and challenges in your own research
    • Understand the reasoning behind data processing
      and statistical analysis
    • Gain a working familiarity with bioinformatics tools
      for exploratory analysis
    A sample schedule from the 2014 workshop is available for PDF download. For more information visit the MRC2 event page.
    STAR.Awards
    Looking for Funding to Explore
    Your Research Idea?
    STAR Awards from the U-M Depression Center
    can help! 

    The U-M Depression Center is currently seeking proposals for its Strategic Translational Research Awards (STAR Awards) Program. STAR Awards are specifically designed for exploring and testing research ideas pertaining to depression-related research.

     

    Strategic Translational Research Awards Program 

    Proposal Deadline:
    Monday, June 1
    Research Focus:
    These awards are designed for exploring or testing research ideas. Funds may be used to gather additional and new quantitative or qualitative pilot data, refine methodology, test tools, analyze data, or further any aspect of depression-related research.

    Preference will be given to proposals containing innovative and original ideas brought forth by the trainee and are not incremental to an extant research program.
    Eligibility:
    This opportunity is available to Depression Center members who are students, residents, fellows, or post-doctoral candidates.

    Those who are not currently members can review membership criteria here.
    Award Amount:
    $10,000
    Number of Potential Awardees:
    Two

     

    Proposals should be submitted via UMMS Competition Space. Please contact Kim Weber in the Depression Center via email with questions about the application process. 

    Life.Science.Suppliers
    Connect with Life Science Suppliers
    Join Procurement Services on Thursday, May 21
    Click image to view and download event flyer.

    Join U-M Procurement Services at their upcoming Life Science Suppliers Show for lunch and to learn more about how key research supply vendors can help your unit save money! 

     

    The show will feature a number of research supply vendors ready to discuss your needs, as well as the most cost-effective way to purchase supplies with representatives from Procurement Services. Vendors will also be showcasing some of their new instruments and products. 

     

    Participating research supply vendors:

    • Bio-Rad
    • Dot Scientific, Inc.
    • EMD Millipore
    • Harlan Laboratories
    • Life Technologies
    • Sigma-Aldrich
    • Qiagen 

    Life Science Suppliers Show

    Thursday, May 21

    11:00 AM - 1:30 PM

    Second Floor Atrium, MSRB III 

    1150 Medical Center Drive


     And don't forget to enter a drawing to win one of six U-M coolers!

     

    For more information, please contact Life Science Procurement Agent Kelly Pavlica via email or phone at (734) 615-8767.

    MSIS.Survey
    Your Input Requested:
    How Well is MSIS Serving You?

    A few times a year, Medical School Information Services (MSIS) runs an anonymous survey to ask what you think of the work they do. That survey is now open, so please share your opinions by following this link.


    Only the first question is required and it takes a few seconds to complete. Any additional questions are optional and should only take a few minutes if you choose to tackle them. What you share will help direct MSIS improvement efforts, and this survey will be reissued periodically to help track the effectiveness of those efforts over time. If you're curious, feel free to read more about 
    their survey methods or browse previous results reports. 

    Take a moment to make yourself heard and, if you have any questions, just send us a note
    .

    SharpFocus
    A0 or A1? Outlining Options for
    NIH Resubmission
    Sharpening Your Focus:
    Tips on Grant Proposal Preparation
    By Jill Jividen, Ph.D., Senior Manager
    for Research Development Support,
    U-M Medical School Office of Research

     

    (One in a series of tips published in UMMS Research News about writing proposals.)
     

    Last year, the National Institutes of Health (NIH) updated its resubmission policy in response to researchers' fears that too many meritorious proposals were deemed ineligible by a two-strike system; until 2014, applicants were forced to overhaul ideas significantly before submitting new proposals.

     

    The updated policy essentially allows for unlimited resubmissions: if an A1 (revised, resubmitted) application proves unsuccessful, researchers may resubmit the idea as an A0 (new application) without substantially changing content or scope. NIH hopes that increased feedback means increased strength, feasibility, and fundability of proposals.

     

    It also means options. Read summary statements carefully.
    Minor revisions and clarifications warrant an A1 resubmission, but extensive overhauls may justify an A0.

     

    Duplicate or highly overlapping applications are still prohibited; additionally, researchers may not submit A1s before A0 summary statements come back. But, A1s are not required before resubmitting (improved) ideas as A0s.

     

    Compare options below:

    A0
    A1
    Does not require introductionRequires introduction to summarize changes, address reviewer comments
    Reviewers instructed to respond to application as "new," even if they've seen
    it previously
    Reviewers can see effort put into revision, addressing critiques
    Should not refer to previous submissionsShould include revisions
    (but no longer requires changes marked in text)
    May be submitted to new
    Study Section
    May request change in
    Study Section via cover letter (discuss with PO or SRO to see if this might be appropriate)
    N/AMust be submitted within
    37 months of A0
    Success rate for new R01s
    is at around 15%
    Historically, success rates
    for A1s higher than A0s


    For more information, please visit the NIH's Resubmission
    Frequently Asked Questions page.

    Office of Research
    Our mission in the Office of Research is to foster an environment of innovation and efficiency that serves the U-M Medical School community and supports biomedical science from insight to impact.