SEPTEMBER 29, 1982 - Newlyweds Stanley and Theresa Janus returned home from their honeymoon to mourn with their family after Stanley's older brother Adam had died suddenly of heart failure at the age of 27. Stanley and Theresa both complained of headaches and each took Tylenol from Adam's bathroom. Within minutes Stanley and Theresa had collapsed to the floor, and both were dead a short time later. All three were victims of the Chicago Tylenol murderer, but the tragedy for the family did not end there. Prior to leaving on their honeymoon Stanley had named Theresa as the primary beneficiary of a $100,000 life insurance policy at his work, with his mother as the contingent beneficiary. Stanley was declared dead on September 29, but Theresa was not officially declared dead until October 1, even though her condition had remained unchanged since September 29. Because Theresa "survived" Stanley she received his life insurance proceeds, which were subsequently paid out to Theresa's family after she was declared dead less than 48 hours later. Despite a lawsuit filed by Stanley's mother which argued that it was clearly not Stanley's intent to leave his life insurance policy to Theresa's family instead of his own, the court nevertheless upheld the strict reading of the law and Theresa's family prevailed.

Along with the Chicago Tylenol Murders, here is a list of five of the most-famous unsolved murders in American history:

JONBENET RAMSEY - In 1996 a six-year-old beauty queen was found dead in the basement of her home in Boulder, Colorado. Earlier in the day a ransom note had been found demanding $118,000 for her safe return, but no call ever came in from a kidnapper. The case has held a steady place in tabloid newspapers in the 17 years since it occurred. While several family members have fallen under suspicion no charges have ever been filed.

THE PHANTOM KILLER - In 1946, the twin cities of Texarkana, Texas, and Texarkana, Arkansas, were gripped with fear for several months as five people were murdered and three more injured by a mysterious killer. The attacks were always at night on the weekends, almost always three weeks apart. The killer was described by one of the victims as a six-foot-tall man with a plain white sack over his head, which had holes cut out for the eyes and mouth. The murders inspired the 1976 horror film The Town That Dreaded Sundown.

THE ZODIAC KILLINGS - Over a 10 month period in 1969, a serial killer in the San Francisco Bay area, who called himself the Zodiac, carried out at least five murders. The killer often reported his murders and sent coded messages to local newspapers. At one point he even sent in a piece of a shirt covered with one victims blood to prove that he was the actual killer. The murders remain unsolved and inspired the 2007 movie Zodiac.