Arthrogryposis multiplex congenita (AMC) is not a specific diagnosis; it is used to describe a condition in which there are multiple joint contractures in more than one region of the body that are usually symmetrical in appearance and are present at birth. AMC is an autosomally dominant inherited nonprogressive musculoskeletal disorder that is now viewed as a condition associated with a heterogeneous group of other diseases, syndromes, or disorders.Joint deformities are secondary changes due to the presence of joint hypomobility. There is no systemic involvement. Patients' sensation and intellect are unaffected.

There is a large void in published literature regarding the effectiveness of rehabilitation (physical therapy, splinting) of patients with AMC prior to surgical intervention or postsurgical intervention. This is partially due to the heterogeneous nature of the disorders/syndromes associated with AMC. Early intervention with physical therapy is still recommended to optimize functional mobility and impede the development of joint contracture, despite a void in the literature. Gentle stretching and splinting to reduce joint contractures and developmentally appropriate strengthening should begin as early as possible.