IonSense
WHAT'S NEW WITH DART® MS?                                    November 2014  
 The Latest Developments in Direct Analysis in Real Time Mass Spectrometry 
 


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We would like to wish you all the best for the Holiday Season and thank you for your continued interest in DART-MS.

We have a few new publications to share with you and have a final announcement for the upcoming Tampa Forensics Symposium: DART-MS in Forensics and Security January 22 in Tampa, Florida.  We have speakers on drug chemistry, propellents, and counterfeits as well as a live demonstration.  It immediately precedes the Sanibel Conference on Security and Forensic Applications of Mass Spectrometry.

 Feel free to contact me if you have any questions or comments.  Thanks.


Regards,

Brian Musselman, Ph.D.
President and CEO

The Tampa Forensics Symposium:  DART-MS in Forensics and Security - January 22, 2015

In collaboration with the University of Tampa, we are pleased to let you know about the upcoming  Tampa Forensics Symposium: DART-MS in Forensics and Security.  This half-day event will feature leaders in the field discussing their latest advances in the areas such as pharmaceutical identification, explosives analysis, designer drugs, and new highly sensitive methods of trace analysis.

In addition we will have LIVE demonstration of DART on the MassTech MT-50 Explorer, a Site-ReadyTM MS/MS instrument for rapid, simple screening of a wide range of materials and compound types.

There is no cost to attend the Forum and for those of you traveling to the Sanibel Conference, we are providing free transportation from the University of Tampa to the Sanibel meeting in Clearwater.

A light lunch and registration will be from 12:00-12:30 followed by the technical program and demonstration.

Introduction to DART-MS Technology and Workflows for Rapid Testing
Brian Musselman, Ph.D., CEO, IonSense

DART Analysis of Counterfeit Drugs
Facundo M. Fernández, Ph. D. , Professor, School of Chemistry and Biochemistry-Georgia Institute of Technology.

Accelerated Analysis of Trace Evidence by DART-MS: Propellants and Projectiles
Adam B. Hall, Ph.D., D-ABC, Director, Mass Spectrometry Facility - Barnett Institute of Chemical and Biological Analysis at Northeastern University

A New Mobile DART-MS System for Rapid On-Site Analysis
Berk Oktem, Ph.D., Research Scientist, MassTech Inc.

DART-TOF MS as the Primary Screening Technique in a Drug Chemistry Workflow
Erin Shonsey, Ph.D., Assistant Professor of Forensic Chemistry at the University of Tampa

An Anniversary Retrospective: Ten Years of DART in the Forensic Sciences
Chip Cody, Ph.D., JEOL USA


 

Recent DART Publications

Combination of Solid-Phase Micro-Extraction and Direct Analysis in Real Time-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Sensitive and Rapid Analysis of 15 Phthalate Plasticizers in Beverages

 

Mengxi Wu, Haoyang Wang, Guoqing Dong, Brian D. Musselman, Charles C. Liu and Yinlong Guo

 

 

Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; IonSense, Inc. Saugus, MA , USA; ASPEC Technologies Limited, Beijing, China

 

 

A method for rapid identification and quantification of phthalate plasticizers in beverages was developed. A number of 15 phthalate plasticizers which covered all the phthalates concerned in the US Consumer Product Safety Improvement Act (CPSIA), European Union legislations and Chinese national standards (GB) were analyzed. By a combined solid-phase micro-extraction (SPME) and direct analysis in real time mass spectrometry (DART-MS) approach, phthalates at sub-ng·mL−1 levels can be qualitatively and quantitatively analyzed in a short time. The use of ultrahigh-resolving power and the accurate mass measurement capacity naturally provided by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) minimizes the matrix interferences and thus enables the evaluation of phthalates in a complex matrix without extensive sample handlings or preparations. The limits of quantification (LOQs) were estimated to be at 0.3-5.0 ng·mL−1, lower than the Maximum Residue Limit (MRL) regulated by the European Union legislations (2007/19/EC) in foods, beverages, food packaging and toys (0.3-30 ng·mL−1). This rapid and easy-to-use SPME-DART-FT-ICR-MS method provided a relatively high-throughput and powerful analytical approach for quick testing and screening phthalates in beverages and water samples to ensure food safety.

 


G. Asher Newsome, Luke K. Ackerman, and Kevin J. Johnson

Nova Research, Inc., Alexandria, Virginia; US-FDA Center for Food Safety and Applied Nutrition, Office of Regulatory Science - Division of Analytical Chemistry, College Park, Maryland; US Naval Research Laboratory, Naval Technical Center for Safety and Survivability, Washington, DC, United States

 

Unstable explosive hexamethylene triperoxide diamine (HMTD) is dangerous in quantity and benefits from the minimal sampling handling associated with atmospheric pressure chemical ionization for mass spectral analysis. Seasonal variation observed in HMTD mass spectra suggested a humidity dependence. Therefore, direct analysis in real time (DART) ionization mass spectra were acquired at a range of humidity values. An enclosure was designed to fit around the ion source and mass spectrometer inlet at atmospheric pressure. The enclosure was supplied with controlled amounts of humidified air from a test atmosphere generator to create programmable conditions for ambient analysis. The relative abundance and fragmentation of analyte ions were observed to change reliably with changing humidity values and, to a lesser degree, temperature. Humidity at such plasma-based ion sources should be regulated to avoid ∼90% shifts in relative ion abundance and provide stability and reproducibility of HMTD analysis.

 

 

Ze Li, Yi-Wei Zhang, Yi-Ding Zhang, Yu Baia and Hu-Wei Liu  

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

 

A simple direct analysis in a real time-mass spectrometry (DART-MS) method was developed for the rapid determination of four Sudan dyes (I-IV) in chili powder. Simple liquid extraction by hexane without further clean-up was used for sample preparation. DART parameters were systematically optimized to achieve the best detection performance. A DIP-it sampler was used for automatic sampling. The matrix effect was measured by comparing the limit of detection (LOD) in matrix solution with that in pure organic solution. Eventually, the identification of the Sudan dyes was confirmed by MS/MS results and the LODs for four analytes in matrix solution were 0.5 μg mL−1. The method showed good linearity with correlation coefficients (R2) greater than 0.99 for concentrations ranging from 1 to 20 μg mL−1. The whole analytical process could be completed within 15 minutes with good recoveries (88-116%) and satisfactory repeatability (<26%, n = 3).  

About IonSense
IonSense, Inc. provides OpenSpot Mass Spectrometry™ solutions to the fields of food safety, forensics, drug development, and chemical analysis. We manufacture and develop direct analysis in real time (DART®) technology licensed from JEOL USA, Inc. and atmospheric solids analysis probe (ASAP™) licensed from M&M Consulting.

DART and ASAP Sources are available for most commercial LC/MS systems.  Look here to see if your system is DART-ready.  And  check here to see if your system is ASAP-ready.

For your local representative, please see our distributor network.

Phone - 781.484.1043  | info@ionsense.com | http://www.ionsense.com
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