WHAT'S NEW WITH DART® MS?                                    November 2014  
 The Latest Developments in Direct Analysis in Real Time Mass Spectrometry 

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We are pleased to let you know that the complete DART Bibliography is now available on-line.  All 320 citations load so it takes a few seconds.  You can view abstracts, journal sites, and can download the entire bibliography. 

Additionally we will be having the first DART-MS Forum on Forensics and Security January 22 in Tampa, Florida.  We have speakers on drug chemistry, propellents, and counterfeits.

 Feel free to contact me if you have any questions or comments.  Thanks.


Brian Musselman, Ph.D.
President and CEO

The Complete DART-MS Bibliography

We now have the complete DART bibliography with abstracts available for browsing.  You can sort by year, author, or keywords. 

You can also view the journal reference by clicking the little box with arrow

Click here to view the DART Bibliography

If you have papers that are not included in the Bibliography, please send us the pdf or link and we will include them


The First DART-MS Forum on Forensics and Security - January 22, 2015

In collaboration with the University of Tampa, we are pleased to let you know about the upcoming  DART-MS Forum on Forensics and Security.  This half-day Forum will feature leaders in the field discussing their latest advances in the areas such as pharmaceutical identification, explosives analysis, designer drugs, and new highly sensitive methods of trace analysis.

In addition we will have LIVE demonstration of DART on the MassTech MT-50 Explorer, a site-ready MS/MS instrument for rapid, simple screening of a wide range of materials and compound types.

There is no cost to attend the Forum and for those of you traveling to the Sanibel Conference, we are providing free transportation from the University of Tampa to the Sanibel meeting in Clearwater.

A light lunch and registration will be from 12:00-12:30 followed by the technical program and demonstration.

Introduction to DART-MS Technology and Workflows for Rapid Testing
Brian Musselman, Ph.D., CEO, IonSense

DART Analysis of Counterfeit Drugs
Facundo M. Fernández, Ph. D. , Professor, School of Chemistry and Biochemistry-Georgia Institute of Technology.

Accelerated Analysis of Trace Evidence by DART-MS: Propellants and Projectiles
Adam B. Hall, Ph.D., D-ABC, Director, Mass Spectrometry Facility - Barnett Institute of Chemical and Biological Analysis at Northeastern University

A New Mobile DART-MS System for Rapid On-Site Analysis
Berk Oktem, Ph.D., Research Scientist, MassTech Inc.

DART-TOF MS as the Primary Screening Technique in a Drug Chemistry Workflow
Erin Shonsey, Ph.D., Assistant Professor of Forensic Chemistry at the University of Tampa

An Anniversary Retrospective: Ten Years of DART in the Forensic Sciences
Chip Cody, Ph.D., JEOL USA


Recent DART Publications

Detection of trace palladium by direct analysis in real time mass spectrometry (DART-MS)


Qingfen Zhanga, Jennifer Bethkeb, Marcel Pateka


Sanofi, Tucson Research Center, Tucson, AZ, United States


Department of Chemistry and Biochemistry, University of Arizona, United States


A detection method for palladium by direct analysis in real time (DART-MS) was developed. The method was used for the detection and semi-quantification of palladium in compound samples for which palladium was used during synthesis from compound collections in early drug discovery. The samples containing palladium were mixed with the chelating agent 4-methyl-piperazine-1-carbodithioate and a palladium chelating complex was subsequently formed and detected by DART-MS. The distinct isotopic pattern of palladium was observed and used for its qualitative identification. Semi-quantification was performed based on the peak areas of the extracted ion currents for the four most abundant isotope peaks at m/z 456, 457, 459 and 461. The limit of detection for this method was observed to be 1.2 μM (120 ppb). With DART ionization, rapid analysis of 18 s per sample was achieved with low carryover. Different solvents and chelating agents were also tested for this analysis, and satisfactory signal intensity was obtained using both volatile and nonvolatile solvents.


Ákos Kuki, Lajos Nagy, Tibor Nagy, Miklós Zsuga, Sándor Kéki,

Department of Applied Chemistry, University of Debrecen, H-4032 Debrecen, Egyetem tér 1., Hungary


The residual tobacco smoke contamination (thirdhand smoke, THS) on the clothes of a smoker was examined by direct analysis in real time (DART) mass spectrometry. DART-MS enabled sensitive and selective analysis of nicotine as the indicator of tobacco smoke pollution. Tandem mass spectrometric (MS/MS) experiments were also performed to confirm the identification of nicotine. Transferred thirdhand smoke originated from the fingers of a smoker onto other objects was also detected by DART mass spectrometry. DART-MS/MS was utilized for monitoring the secondhand tobacco smoke (SHS) in the air of the laboratory using nicotine as an indicator. To the best of our knowledge, this is the first report on the application of DART-MS and DART-MS/MS to the detection of thirdhand smoke and to the monitoring of secondhand smoke.



Osamu Kiguchia, Kazuko Okab, Masafumi Tamadac, Takashi Kobayashic, Jun Onoderab

Faculty of Bioresource Sciences, Akita Prefectural University, 241-438 Kaidobata-nishi, Shimoshinjo-nakano, Akita 010-0195, Japan
JEOL Ltd., 1-2 Musashino 3-chome, Akishima, Tokyo 196-8558, Japan
Akita Research Center for Public Health and Environment, 6-6 Senshu-kubotacho, Akita 010-0874, Japan


To assess food safety emergencies caused by highly hazardous chemical-tainted foods, simultaneous analysis of organophosphorus insecticides in fatty foods such as precooked foods was conducted using thin-layer chromatography/direct analysis in real time time-of-flight mass spectrometry (TLC/DART-TOFMS) and isotope dilution technique. Polar (methamidophos and acephate) and nonpolar organophosphorus insecticides (fenitrothion, diazinon, and EPN) were studied. Experiments to ascertain chromatographic patterns using TLC/DART-TOFMS reveal that it was more useful than GC/MS or GC/MS/MS for the simultaneous analyses of polar and nonpolar pesticides, while obviating the addition of a protective agent for tailing effects of polar pesticides. Lower helium gas temperature (260 °C) for DART-TOFMS was suitable for the simultaneous analysis of target pesticides. Linearities were achieved respectively at a lower standard concentration range (0.05-5 μg) for diazinon and EPN and at a higher standard concentration range (2.5-25 μg) for methamidophos, acephate, and fenitrothion. Their respective coefficients of determination were ≥0.9989 and ≥0.9959. A few higher repeatabilities (RSDs) for diazinon and EPN were found (>20%), although isotope dilution technique was used. Application to the HPTLC plate without an automatic TLC sampler might be inferred as a cause of their higher RSDs. Detection limits were estimated in the higher picogram range for diazinon and EPN, and in the lower nanogram range for methamidophos, acephate, and fenitrothion. Aside from methamidophos, recovery results (n = 3) obtained using a highly insecticide-tainted fatty food (dumpling) and raw food (grapefruit) samples (10 mg/kg) using TLC/DART-TOFMS with both complex and simpler cleanups were not as susceptible to matrix effects (95-121%; RSD, 1.3-14%) as those using GC/MS/MS (102-117%; RSD, 0.4-8.5%), although dumpling samples using GC/MS were remarkably susceptible to matrix effects. The coupled method of TLC with simpler cleanup and DART-TOFMS can be regarded as the same analytical tool as GC/MS/MS, which is useful to assess food safety emergencies caused by highly hazardous chemical-tainted foods.
About IonSense
IonSense, Inc. provides OpenSpot Mass Spectrometry™ solutions to the fields of food safety, forensics, drug development, and chemical analysis. We manufacture and develop direct analysis in real time (DART®) technology licensed from JEOL USA, Inc. and atmospheric solids analysis probe (ASAP™) licensed from M&M Consulting.

DART and ASAP Sources are available for most commercial LC/MS systems.  Look here to see if your system is DART-ready.  And  check here to see if your system is ASAP-ready.

For your local representative, please see our distributor network.

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