WHAT'S NEW WITH DART® MS?                                         May 2014  
 The Latest Developments in Direct Analysis in Real Time Mass Spectrometry 

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With the annual ASMS meeting fast approaching, we would like to let you know about the activities and events that are featuring DART technology and its various applications.  From the DART Forum to the many presentations, we look forward to seeing you in Baltimore.

Additionally our new partner, GenTech Scientific, is offering complete DART-MS systems so please read the details below.

 Feel free to contact me if you have any questions or comments.  Thanks.


Brian Musselman, Ph.D.
President and CEO

GenTech Scientific Offering the ID-CUBE® Source with Thermo Mass Spectrometers


GenTech Scientific brings the next generation of DART technology to the market in a complete MS system. The DART-compatible, pre-owned mass spectrometers, like the Thermo TSQ Quantum Access Triple Quad or the Thermo Finnigan LCQ Deca LC/MS/MS, are fully refurbished to their original manufacturer specifications and thoroughly tested before being listed for sale. When coupled with the IonSense ID-CUBE, these mass spectrometers offer labs superlative DART performance without a superlatively large price tag. 


To learn more about DART compatible mass spectrometers, financing availability and other options for your lab from GenTech Scientific, call 595-492-1068 or visit



Register now for the Annual DART Forum at ASMS 2014

From extraterrestrial organics to pharmaceuticals and drugs of abuse, DART is helping researchers and scientist rapidly find answers.  Come to the annual DART Forum at ASMS in Baltimore on June 15 to hear the latest from leaders in the field.

IonSense DART Forum 2014  

Sunday, June 15, 2014 from 2:00 PM to 4:30 PM  

Marriot Inner Harbor at Camden Yards, 110 South Eutaw St., Baltimore,MD


Eventbrite - IonSense DART Forum 2014

Featured Speakers

Case Studies of the Application of DART/MS to Pharmaceutical Analytical Challenges

R. Randy Wilhelm, Mallinckrodt Pharmaceuticals


Pharmaceutical Identifier Confirmation via DART-TOF

Jacob Easter, Virginia Department of Forensic Science


Optimization of Thin Film Solid Phase Microextraction (SPME) Devices for Direct Analysis in Real Time (DART) Coupled with Tandem Mass Spectrometry

German Augusto Gómez-Ríos, University of Waterloo


Simple Separations and Isolations Coupled with DART-MS: an Update on TLC and Profiling Approaches

Elizabeth Crawford, ICT Prague and IonSense, Inc.


Metabolite Profiling by Direct Analysis in Real Time Mass Spectrometry

Christina Jones, Georgia Institute of Technology


Assorted Adventures with DART

Chip Cody, JEOL USA


Dynamic Headspace Sampling Utilizing Sorbent Coated Mesh for the Characterization and Differentiation of Energetic Materials: Analysis by DART

Adam B. Hall, Northeastern University


Investigation of Extraterrestrial Organics via DART mass spectrometry

Michael Callahan, NASA Goddard Space Flight Center


DART MS Presentations at ASMS 2014

There are over 30 DART MS presentations at the upcoming ASMS meeting, and to make your navigation easier, we have compiled a list here for you to download.  Just click the link to see the list.

Recent Publications on DART MS

Hye Jin Kim, Yong Taek Seo, Sang-il Park, Se Hee Jeong, Min Kyoung Kim, Young Pyo Jang 

Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea; Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea  


Rapid and efficient identification of the geographical origin of Angelica gigas roots (dang-gui) was performed using DART-TOF-MS (direct analysis in real time-time of flight-mass spectrometry) based metabolomics. As an ambient desorption/ionization technique, DART-TOF-MS can provide soft ionization and rapid analysis of samples with little sample preparation so it has been advantageously applied to high-throughput metabolomics analysis. In order to develop an efficient tool for discriminating, particularly geographical origin of raw herbal medicine, we employed DART-TOF-MS fingerprinting on dang-gui from Korean and Chinese markets. Principal component analysis of DART-TOF-MS fingerprints gave distinctive clustering information among two species of A. gigas and A. sinensis so that we used only A. gigas species for the sequential experiment. Orthogonal projections to latent structures-discriminant analysis of A. gigas samples revealed the separation between samples cultivated in two countries. Major discriminating components were elucidated as decursin/decursinol angelate, unidentified molecular ion of m/z 247 (protonated ions of molecular formula of C14H14O4) and another molecular ion of m/z 432. DART-TOF-MS based chemical fingerprinting with the multivariate analysis of dang-gui was shown to be efficient and accurate way to identify its geographical origin, between Korea and China.

María Eugenia Monge, Prabha Dwivedi, Manshui Zhou, Michael Payne, Chris Harris, Blaine House, Yvonne Juggins, Peter Cizmarik, Paul N. Newton, Facundo M. FernándeZ, David Jenkins

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia USA; Product Quality and Compliance, FHI 360, Durham, North Carolina USA; Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR; Centre for Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom; WorldWide Antimalarial Resistance Network, Churchill Hospital, University of Oxford, Oxford, United Kingdom

Reproductive health has been deleteriously affected by poor quality medicines. Emergency contraceptive pills (ECPs) are an important birth control method that women can use after unprotected coitus for reducing the risk of pregnancy. In response to the detection of poor quality ECPs commercially available in the Peruvian market we developed a tiered multi-platform analytical strategy. In a survey to assess ECP medicine quality in Peru, 7 out of 25 different batches showed inadequate release of levonorgestrel by dissolution testing or improper amounts of active ingredient. One batch was found to contain a wrong active ingredient, with no detectable levonorgestrel. By combining ultrahigh performance liquid chromatography-ion mobility spectrometry-mass spectrometry (UHPLC-IMS-MS) and direct analysis in real time MS (DART-MS) the unknown compound was identified as the antibiotic sulfamethoxazole. Quantitation by UHPLC-triple quadrupole tandem MS (QqQ-MS/MS) indicated that the wrong ingredient was present in the ECP sample at levels which could have significant physiological effects. Further chemical characterization of the poor quality ECP samples included the identification of the excipients by 2D Diffusion-Ordered Nuclear Magnetic Resonance Spectroscopy (DOSY 1H NMR) indicating the presence of lactose and magnesium stearate.

Xin Wang , Xianjiang Li , Ze Li , Yiding Zhang , Yu Bai , and Huwei Liu

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, People's Republic of China

Online coupling of in-tube solid phase microextraction (IT-SPME) with direct analysis in real time mass spectrometry (DART-MS) was realized for the first time and applied in the analysis of triazine herbicides in lake water and orange juice. We incorporated single-wall carbon nanotubes (SWNTs) into a polymer monolith containing methacrylic acid (MAA) and ethylene dimethacrylate (EDMA) to form a novel poly(methacrylic acid-co-ethylene dimethacrylate-co-single wall carbon nanotubes) (poly(MAA-EDMA-SWNT)) monolith, which was then used in IT-SPME for enrichment of six triazine herbicides from water samples. With the online combination of IT-SPME with DART-MS, the analytes desorbed from the monolith were directly ionized by DART and transferred into MS for detection, thus rapid determination was achieved. Compared with regular DART-MS method, this online IT-SPME-DART-MS method was more sensitive and reproducible, because of the IT-SPME procedures and the isotope-labeled internal standard used in the experiment. Six triazine herbicides were determined simultaneously using this method with good linearity (R2 > 0.998). The limit of quantification (signal-to-noise ratio of S/N = 10) of the six herbicides were only 0.06-0.46 ng/mL. The proposed method has been applied to determine triazine herbicides in lake water and orange juice, showing satisfactory recovery (85%-106%) and reproducibility (relative standard deviation of RSD = 3.1%-10.9%).

About IonSense
IonSense, Inc. provides OpenSpot Mass Spectrometry™ solutions to the fields of food safety, forensics, drug development, and chemical analysis. We manufacture and develop direct analysis in real time (DART®) technology licensed from JEOL USA, Inc. and atmospheric solids analysis probe (ASAP™) licensed from M&M Consulting.

DART and ASAP Sources are available for most commercial LC/MS systems.  Look here to see if your system is DART-ready.  And  check here to see if your system is ASAP-ready.

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