IonSense, Inc
 June 2013
What's New with DART? 
The latest developments and news on DART® Mass Spectrometry 

We are all looking forward to the ASMS meeting in Minneapolis next week and want to let you know what is happening with DART.  

We will be exhibiting our new DART GSX for the Agilent GC/MSD as well as our other DART sources for all your LC/MS instruments. We also are now offering accurate mass on the MSD through our partnership with Cerno Bioscience, which you can read about here.  Please stop by our Booth #142 to see what is new in rapid screening technology.

And of course, many researchers are presenting their work on DART, and we have a list of their contributions below.

Please have a look and contact me if you have any questions or comments.


BM signature

Brian Musselman
President and CEO
IonSense, Inc.
DART Presentations at the ASMS 2013


Here is a list of presentations involving Direct Analysis in Real Time technology.  


Electro-Thermal Vaporizer (ETV) Direct Analysis in Real Time-Mass Spectrometry (DART-MS) For Sensitive and High Throughput Water Contaminant Analysis

MP15    265         Prabha Dwivedi; Daniel Gazda; William Wallace; Thomas  Limero; Ariel Macatangay; Facundo Fernandez  Georgia Inst. of Technology, Atlanta, GA-30332; NASA-JSC/SK4/Wyle Sc., Tech., and Eng. Group, Houston, TX-77058; NASA-JSC/SF4, Houston , TX-77058


Improved LC-DART-MS interface for reaction monitoring and impurity analysis in non-ESI-friendly solvents 

MP15    266         Adam Kaylor; Prabha  Dwivedi; Guilong Cheng; Facundo Fernandez         Georgia Institute of Technology, Atlanta, GA; Pfizer Analytical R&D, Pharmaceutical Science, Groton, CT


Effective Ion Transmission Scheme for Ambient Plasma-based Discharge Sources Coupled with Drift Tube Ion Mobility Spectrometry     

MP15    267         Joel Keelor; Prabha Dwivedi; Facundo Fernandez             Georgia Institute of Technology, Atlanta, GA


Implementation of Ambient Ionization sources on a low cost GC/MSD and assessment of its performance

MP17    342         Joseph Tice; Michael Festa; Taylor Feraco; Brian D.  Musselman; Randy Pedder; John Mazock     IonSense, Inc., Saugus , MA; Ardara Technologies, Ardara, PA


A Multi-Platform Strategy Applied to the Detection and Characterization of Falsified Artemisinin Combination Therapies

MP30    606         Prabha Dwivedi; Maria Julia Culzoni; Mohamed  El-Sherbiny; Obinna  Onwujekwe; Ogochukwu Ezeoke; Naiela Malik; Ifeyinwa Fadeyi; Harparkash Kaur; Facundo M. Fernández               Georgia Institute of Technology, Atlanta, GA; London School of Hygiene and Tropical Medicine, London, UK; College of Medicine, University of Nigeria, Enugu, Nigeria


Utilization of DART ion source coupled with HR/AM Q-Orbitrap MS for car paint component identification for traffic accident criminal investigation

MP30    621         Wei-Shun Lai; Tai-Hung Chen; Hsin-Hung Huang; Shu-Hui Lee      Mass Solutions Technology, New Taipei, TAIWAN; Criminal Investigation Brigade, Taipei, Taiwan


High throughput characterization of biopolyol using DART-MS with ultra-fast polarity switching

MP36    733         Christopher Gilles; Keiko Matsumoto; Teruhisa  Shiota; Jun Watanabe; Mariko Yoshioka; Nobuo Shiraishi       SHIMADZU SCIENTIFIC INSTRUMENTS,INC., Columbia, MD; Shimadzu Corporation, Kyoto, JAPAN; AMR, Inc, Tokyo, Japan; Kyoto University, Kyoto, Japan; SHIRAISHI BIOMASS CO., Ltd., Kyoto, Japan


Screening herbal supplements using statistical modeling to find and identify adulterants and contaminants using direct analysis in real time (DART)-MS

TOC am        08:50     Nick Levitt; Joseph LaPointe; Michael Festa; Elizabeth Crawford             TwoCenter Technologies, Cambridge, MA; IonSense  Inc., Saugus, MA


Screening Large Sample Sets for Contaminants by DART-MS: Limitations & Advantages

TOE pm        2:30           Luke Ackerman; Karim Bentayeb; Timothy Begley            FDA Center for Food Safety, College Park, MD; Univ. Zaragoza, Analytical Chem, Zaragoza, Spain


Preventing Wine Spoilage:  Rapid Screening and Quantitative Analysis of Off-flavor Phenolic Compounds by DART Mass Spectrometry

TOE pm       3:50        Elizabeth Crawford; Paola Domizio; Brian Musselman; Lucy Joseph; Linda Bisson; Bart Weimer; Richard Jeannotte               Institute of Chemical Technology Prague, Prague, Czech Republic; Universitŕ degli Studi di Firenze, Florence, Italy; IonSense, Inc., Saugus, MA; UC-Davis Dept. of Viticulture & Enology, Davis, CA; UC-Davis Dept. of Health and Reproduction, Davis, CA


A Novel Direct Analysis in Real Time (DART) Mass Spectrometry Method for Determination of Imatinib in human plasma

TP25      425         Kumari Ubhayasekera; Warunika  Aluthgedara; Tommy  Lewander; Jonas Bergquist         Uppsala University, Uppsala, SWEDEN


Rapid Screening of Sorbic and Benzoic Acids in Soy Sauce by Direct Analysis in Real Time Time-of-flight Mass Spectrometry

TP37      751         Xiaojing Ding; Junwei  Huang; Shan  Zhao; Jing Zhang; Echo W. Jia; Bing  Shao; Charles  C. Liu                Beijing Centre for Disease Control and Prevention, Beijing, China; ASPEC Technologies Limited, Beijing, China


Comparison of Two Sample Preparation Methods for Analyzing Pain Management Drugs in Urine

WP07    113          Xuejun Zang; Igor Gavin; Krishna Mallia; Asha Oroskar; Anil Oroskar         Orochem Technologies Inc., Lombard, IL


An enzyme assay mass screening system for adenosine deaminase deficiency from dried blood spots using a DART MS/MS

WP07    114         Hideki Nakajima; Teruhiko Miwa; Kazuhiro Kida; Jun Watanabe; Teruhisa Shiota; Torayuki Okuyama; Masafumi Onodera; Junichiro FujimotoNational Center for Child Health and Development, Tokyo, Japan; Shimadzu Corporation, Kyoto, JAPAN; AMR, Inc., Tokyo, Japan


Mass Spectrometric Detection of Local Anesthetics Masking Prohibited Practice of Inducing Limb Soring in Walking Horses to Enhance Appeal

WP14    238         Szabolcs Szarka; Laszlo Prokai     UNT Health Science Center, Fort Worth, TX


Rapid analysis of triglycerides and fatty acids in food oils using DART-MS with high-speed polarity switching

WP19    326         Shun Wada; Jun Watanabe; Keiko Matsumoto; Teruhisa Shiota; Shingo Toda       Japan Inst. of oil & fats, other foods Inspection, Tokyo, Japan; Shimadzu Corporation, Kyoto, JAPAN; AMR, Inc., Tokyo, Japan


Analysis of Triglycerides in Plant Oils by Direct Analysis in Real Time

WP19    353         Igor Gavin; Anil  Oroskar; Asha Oroskar                Orochem Technologies Inc., Lombard, IL


Coupling Neutral Desorption to Dielectric Barrier Discharge Ionization Mass Spectrometry for Direct Analysis of Oil Samples

WP20    363         Yafei Zhou; Zhongchen Wu; Cao Li; Nannan Wang; Saijin Xiao; Xinglei Zhang; Eric Handberg; Huanwen ChenEast China Institute of Tech., Nanchang, China; Shandong University, Weihai, China


Use of Sorbent Coated metal probes with Direct Analysis in Real Time (DART) Ionization for rapid analysis of Herbal Supplements

WP37    718         Joseph LaPointe; Robert Goguen; Brian Musselman        Ionsense Inc., Saugus , MA


Characterizing Toothpastes:   Direct Fingerprinting of Key Volatile Flavor and Marker Non-volatile Compounds by DART QToF Mass Spectrometry


WP37    719         Elizabeth Crawford; Brian Musselman; Jerry Zweigenbaum          Institute of Chemical Technology Prague, Prague, Czech Republic; IonSense, Inc., Saugus, MA; Agilent Technologies, Wilmington, DE


Pyrolysis for Rapid Screening of Contaminated Heparin by DART Mass Spectrometry

WP37    720         Peter Nemes; William Hoover; David Keire        US FDA, CDRH, Silver Spring, MD; US FDA, CDER, St. Louis, IL


Rapid Screening of 'White Powders' for Unknown Agents Using a DART-Equipped Compact Mass Spectrometer.

WP37    721         Jack Henion; Brian Musselman; Nigel Sousou      Advion, Inc., Ithaca, NY; IonSense, Saugus, MA


High Resolution Accurate Mass (HRAM) Phthalate Screening using Direct Analysis in Real Time (DART) Ambient Ionization

WP37    722         Catharina Crone; Elizabeth Crawford; Yue Xuan; Markus Kellmann            Thermo Fisher Scientific, Bremen, GERMANY; IonSense Inc., Saugus, MA, USA


Sensitive Screening of Abused Drugs in Raw Urine and Blood by Direct Analysis in Real Time Triple Quadrupole Mass Spectrometry

WP37    723         Wenfang Zhang; Zong Yang; Ping Li; Yong Chen; Dazhou Chen; Charles C. Liu        Forensic Science Service Public Security Bureau, Beijing, CHINA; National Institute of Metrology, Beijing, CHINA; Lumtech Technologies Limited, Beijing, CHINA; Labcare Solutions, Shanghai, CHINA; ASPEC Technologies Limited, Beijing, CHINA  


Quantitation by DART-Orbitrap mass spectrometer: preliminary analysis of pesticides in water by internal standards

WP37    724         Jaewon Choi; Wonseok Choi; Jeheon Jang; Yunduck Kim               Kwater, Daejeon, SOUTH KOREA


Exact and Quantitative Analysis of Deuterated Pyrene :  New Method for the Rapid, Convenient Hydrogen-Deuterium Exchange of Polycyclic Aromatic Hydrocarbons

WP37    725         Mark Domin       Boston College, Chestnut Hill, MA


Rapid Quantitative Analysis of Trimethyl Phosphate in Water with Direct Analysis in Real Time Mass Spectrometry

WP37    726         Xiaowei Wang; Liping Liu; Bing Shao; Jingfu Liu; Charles C.  Liu      Beijing Center for Disease Control and Prevention, Beijing, China; Chinese Academy of Sciences, Beijing, China; ASPEC Technologies Limited, Beijing, China


Progress toward  universal  ionization by combining different ambient ionization methods

ThOA am     08:30        Robert B. Cody; John Dane          JEOL USA, Inc., Peabody, MA


Robotic Plasma Probe Ambient Ionization Mass Spectrometry Imaging of Non-Planar Surfaces

ThP05    052         Ezequiel M. Morzan; Rachel V. Bennett; Facundo M. Fernandez         Universidad de Buenos Aires, Buenos Aires, Argentina; Georgia Institute of Technology, Atlanta, GA


Analysis of bacteria by performing in situ pyrolysis on a DART ID Cube/Time-of-Flight MS

ThP25    499         Yvette R. Hudson; Johnny K. Ho; Danielle N. Dickinson; William A. Harris; Douglas B. Henderson  Northrop Grumman, Linthicum, MD


Development of a fieldable DART-based High Performance Ruggedized Ambient Ionization Mass Spectrometer (DART-HiPR-MS)

ThP26    520         Danielle N. Dickinson; William A. Harris; Hoon Ra; Johnny K. Ho; Yvette R.  Hudson; Douglas B. Henderson; Karl A. Hanold; Robert Tysl Jr.; Paul Chaney; Brian D. Musselman; Joseph Tice       Northrop Grumman, Linthicum, MD; Syagen, Santa Ana, CA; Ionsense, Saugus, MA


Determination of the Silylation of Molecules when using TMS Derivatization Agents in the Sample Gap of the DART Ion Source

ThP30    631         Matthew Curtis; Patrick Henry  Batoon; Patrick Jones; O. David Sparkman             University of the Pacific, Stockton, CA


Have Your Samples Run on the NEW DART GSX

The DART GSX System

The new DART-GSX System enables rapid screening and characterization of samples on the Agilent GC/MSD, which is widely used in many of your labs 


For details on the GSX, you can download the brochure here 


The DART GSX System can be fitted to one of your existing Agilent GC/MSD instruments or it can be supplied as a complete system with a new or refurbished Agilent GC/MSD.  


If you are interested in having samples run on the demonstration unit in Saugus, please let us know




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About IonSense  
IonSense, Inc. provides OpenSpot Mass Spectrometry™ solutions to the fields of food safety, forensics, drug development, and chemical analysis. They manufacture and develop direct analysis in real time (DART®) technology licensed from JEOL USA, Inc. and atmospheric solids analysis probe (ASAP™) licensed from M&M Consulting.

DART and ASAP Sources are available for most commercial LC/MS systems.  Look here to see if your system is DART-ready.  And  check here to see if your system is ASAP-ready.