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 Issue 66October 3 2014 
Science of Salt Weekly is a publication of weekly Medline searches related to dietary sodium. This is an initiative of the Canadian Institute for Health Research & Heart and Stroke Foundation Chair in Hypertension Prevention and Control. Funding has been provided by the Canadian Stroke Network and the George Institute for Global Health.
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Category: Reducing Salt Intake

Toft U.  Cerqueira C.  Andreasen AH.  et al. Estimating salt intake in a Caucasian population: can spot urine substitute 24-hour urine samples?. 

European Journal of Preventive Cardiology.  21(10):1300-7, 2014 Oct.

A study was undertaken to assess the validity of the predicted 24-hour urinary sodium excretion using spot urine as well as evaluate the validity of two prediction models: the Tanaka prediction method and a prediction model developed in a Danish population. Data were based on results from two subsamples of men and women in a Danish population: women (n=248) aged 25-30 years and 60-65 years participated in the Dan Thyr study and men (n=102) and women (n=113) aged 30-60 years participated in the Inter99 study. All 473 participants provided both spot urine (collected at any time during the day) and a 24-hour urine sample collected on a different day than the spot urine sample (within 2 weeks for most participants). The measured 24-hour urinary sodium excretion was compared with the predicted 24-hour sodium excretion from a casual urine specimen, using both prediction methods. Tanaka et al. has developed an equation in a Japanese population using spot urine to predict 24-hour creatinine excretion, and an equation to estimate 24-hour urinary sodium excretion based on measurements of sodium and creatinine in a spot urine sample in combination with the predicted 24-hour creatinine excretion. In developing a Danish prediction model, authors used regression analyses to predict the 24-hour sodium excretion. Results showed that the measured 24-hour sodium excretion (median, 5th to 95th percentile) was 11.2 gm salt/day (6.3gm to 20.7gm) for men and 7.9gm salt/day (3.5gm to 14.8gm) for women. The predicted 24-hour sodium excretion using the Tanaka model was 9.8gm salt/day (6.7gm to 12.7gm) for men and 8.7 salt/day ( to 13.1gm) for women and the predicted 24-hour sodium excretion for the Danish model was 11.9 salt/day (8.3gm to 14.8gm) for men and 7.7gm salt/day (5.9gm to 9.3gm) for women. The Spearman correlation between the predicted and measured 24-hour sodium excretion was 0.39 and 0.49 for the Tanaka and the Danish models, respectively. For both prediction models, the proportion of individuals classified in the same or adjacent quintile was 74% for men and 64% for women. Authors conclude that both prediction models gave a reasonable classification of individuals. However, the median daily sodium intake was estimated more precisely by the Danish model, especially among men.Link to article


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