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Outreach

 

Please listen to an interview about vitamin D with Meg Mangin, RN.

Chronic Illness Recovery will be represented at the American Association of Physician's Assistants Conference May 23-27 in San Francisco. We're excited to meet these clinicians and speak with them about Inflammation Therapy.
 


Science Behind 

Inflammation Therapy

 

Our peer-reviewed article
has been published in the October 2014 issue of Inflammation Research.

 

 

 

Therapy Tip

 

In our experience, of over a dozen years working with thousands of patients, antibiotics are essential to weaken the intracellular bacteria so the immune system, up-regulated by Benicar (olmesartan), can more easily kill them. We've learned that specific antibiotics taken in very low doses and in a pulsed fashion are the most effective at this task. These antibiotics have been well studied and are chosen for their safety as well as their ability to work together in a synergistic fashion to target different bacterial ribosomes. In contrast, little is known about the actions, correct dose and safety of 'natural' substances touted to have an antibacterial effect.

 

 

CIR Library Access

 

Our free, extensive, easy-to-read  

Library of Information

(see this sample page)

is available to anyone.

Please email for a  

request to access. 

   

 

 

 
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Issue: 66
May 2015

Greetings!         

 

Our nurses staffed a booth for Chronic Illness Recovery (CIR) at the American College of Physicians Internal Medicine Meeting April 30 - May 2, 2015 in Boston, MA. We are thrilled to report that the response to our poster and handouts were overwhelmingly positive. Many physicians realized they have a disproportionate number of patients who have low vitamin D levels and they are seeking logical explanations for this conundrum. One physician commented that it was astonishing that, as a non-profit organization, we have no product for sale, and our attendance at this convention was for the sole purpose of educating medical professionals. Thank you Meg and Debbie for your dedicated service at this conference. You are doing a wonderful job.

 

Later this month, Meg will be attending a conference the annual conference for physician's assistants. In June, CIR will staff a booth at the annual conference for nurse practitioners.

 

As we look forward to a busy summer, please remember to take care of yourself, rest as needed and don't overextend yourself.

 

To good health,

 

  signatureBelinda

  

About Inflammation Therapy

 

Intracellular bacteria may alter innate immune response

 

Patients with chronic, non-granulomatous diseases have elevated 1alpha,25-dihydroxyvitamin-D3 [1a,25(OH)2D3] and low 25-hydroxyvitamin-D [25(OH)D]. The absence of hypercalcemia, hypercalciuria, elevated parathyroid hormone, and chronic kidney disease suggests extra-renal production of excess 1a,25(OH)2D3.

 

Extra-renal 1alpha-hydroxylase (CYP27B1) catalyzes 25(OH)D  to 1a,25(OH)2D3 in immune cells, leading to transcription of antimicrobial peptides (AMPs) via the vitamin D receptor (VDR). 1a,25(OH)2D3 production is down-regulated by 1alpha,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) via hydroxylation of 1a,25(OH)2D3 to 1,24,25(OH)3D3. CYP27B1 transcription in macrophages is regulated by cytokines (e.g., Interferon-y [INF-y]). 1a,25(OH)2D3 also interacts with VDR-expressing helper (Th1) and suppressor (Th2) cells to reduce IFN-y production.

 

L-form bacteria (cell-wall-deficient variants that are ubiquitous but difficult to culture) invade immune cells and must use strategies to avoid phagocytosis. Parasitization of macrophages by these pathogens may be the stimulus for persistent production of cytokines which induce CYP27B1 activity and excess 1a,25(OH)2D3 production.

 

Down-regulation of the VDR by intracellular bacteria would interfere with 1a,25(OH)2D3 production regulatory processes and thus, prevent transcription of AMPs to allow bacterial persistence. Bacterial interference with enzymatic traffic patterns could allow production of excess 1a,25(OH)2D3  and prevent normal 1a,25(OH)2D3 functions which inhibit the expression of inflammatory cytokines.

 

Evidence for persistent intracellular bacterial infection and vitamin D metabolism dysfunction has been seen in natural experiments that suggest increased bacterial killing following reduction in elevated 1a,25(OH)2D3.


Non-resolving inflammation associated with many common chronic diseases may be caused by survival strategies of intracellular bacteria and is evidenced by elevated 1a,25(OH)2D3 and depleted 25(OH)D as markers of an infectious disease process.

 

New Scientific Articles

 

A new study in February 2015 showed ergocalciferol therapy improved baseline serum 25-OH vitamin D concentrations but was inadequate for consistently achieving normal serum concentrations of 25-OH vitamin D during critical illness. The trend in increasing appearance of mild hypercalcemia for the highest dosage group is concerning. 

Dickerson, Roland N. et al   

Dose Response Effect of Ergocalciferol Therapy upon Serum 25-hydroxyvitamin D Concentration During Critical Illness

Nutrition. Published online April 4, 2015  

 

New study from Stanford shows bacteria lost their rod-shaped walls and became blob-like L-forms; process of reversion might explain how bacteria develop resistance to antibiotics and establish chronic infections. Video:
Stanford Researchers Unravel The Secrets Of Shape-Shifting Bacteria

 

Quotes 

 

I've tested several patients and find low D but high calcitriol in sick patients with no clear diagnosis. ~MD in Nevada

 

I've been on this treatment since 2002. So I sometimes get discouraged and forget how much better I am now despite I'm 13 years older (73 later this month). ~Sue

 

Recovery Reports 

 

We are contacted daily by people with chronic illnesses who are looking for an effective treatment. Many ask us to provide evidence of efficacy in the form of statistics or stories. If you have recovered your health or had significant symptom improvement with Inflammation Therapy, please help us 'pay it forward' by telling your story. We will post it in the public section of our website to encourage others. Any report, short or long, with or without objective data (e.g., lab results, imaging reports) would be helpful. Please email your story to us. Thank you! 

CIR Counseling Program 

 

For information about how to enroll in the CIR counseling program
please email or call toll-free in the US and Canada. 888.846.2474

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