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Chronic Illness Recovery Newsletter

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 Chronic Illness Workshop

 

Road to Recovery

from Chronic Illness

Hosted by Christ's Church  

of Marion County

Saturday, January 24, 2015  
9:00 - 4:00

 6768 SW 80th St. 

Ocala, Florida
Lunch included

Donations appreciated

Call to register

352.861.6182 

352.861.6182
 

 

 Patient Workshops are offered in any USA mainland locality for a gathering of 10 or more. If you are able to organize a group for a workshop, please contact us at this link

 

Science Behind 

Inflammation Therapy

 

Our peer-reviewed article
has been published in the October 2014 issue of Inflammation Research.

 

 

CIR is an IRS-recognized 501(c)3 non-profit charitable organization. 

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 in support of our educational outreach efforts.

Recovery Reports 
 

 

Therapy Tip

 

Inflammation Therapy evolved from theories based on current scientific evidence & only uses prescription medications. Novel treatments may offer the only chance of survival or an acceptable quality of life for many patients with chronic illnesses. We hope you won't procrastinate, but use your best judgment to make an educated decision and find a supportive doctor who will supervise your treatment.

 

 

 

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Issue: 62
January 2015


Greetings!        

 

Hardly a week goes by that we don't see some news story with new ideas about how chronic inflammation is linked to disease. Recently researchers linked depression to inflammation.   

 

There's still time to escape the winter weather and join us at an an all-day workshop "Recovering from Chronic Diseases" on Saturday, January 24, 2015 in Florida! We will be at Christ's Church Marion County, located at 6768 Southwest 80th Street in Ocala, Florida. Registration is free and open to the public by calling the church office at 352-861-6182. There will be explanations of how low levels of vitamin D may be another symptom of chronic inflammatory disease and may be connected to unresolved, undetected infection. While this workshop is planned for patients and their families, medical professionals are also welcome.  

 

We would love to see you in Florida, but remember we are willing to work with you to arrange a meeting in the USA mainland whenever there is a commitment of 10 or more attendees.  

signature  Belinda

 

 

 

Proposed Research

 

Chronic Illness Recovery is exploring opportunities to conduct studies that will verify the science underpinning Inflammation Therapy and to provide evidence of treatment efficacy. We're excited to be furthering research efforts and will keep you apprised of developments via this newsletter.

 

Study #1: Determine if olmesartan medoxomil is a vitamin D receptor ligand.

Premise: In silico research has concluded olmesartan medoxomil modulates the VDR receptor. [1]

Action: Conduct in vitro research to corroborate the computer modeling and determine if olmesartan agonizes or antagonizes the VDR. Alternatively, duplicate the in silico research.

Reference:

  1. Marshall TG, Lee RE, Marshall FE. Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b. Theor Biol Med Model. Jan 2006;3:1.

 

Study #2: Determine the 1,25(OH)2D range of a healthy population.

Premise: 1,25(OH)2D is usually only measured when patients are very ill. Therefore, normal lab ranges for 1,25(OH)2D (e.g., Mayo Clinic 18-78 pg/ml) may have been skewed high by the presence of patients with dysregulated vitamin D metabolism. Data from a large and reliable Danish study provides 1,25(OH)2D concentrations in a healthy population. Brot et. al [1] found the mean value for 1,25(OH)2D was 29 pg/ml with a standard deviation of 9.5. Furthermore, when measured coincidentally, the significance of elevated 1,25(OH)2D may be overlooked. For example, a study of the effect of vitamin D and calcium supplementation on patients with multiple sclerosis, revealed elevated 1,25(OH)2D at baseline and one year later (61 pg/mL � 22.6 pg/mL and 70.7 pg/mL � 18 pg/mL respectively). [2] These 1,25(OH)2D concentrations were considered normal and neither calcium nor parathyroid hormone were measured.

Action: Verify the data from the Danish study at a research lab with a cohort of apparently healthy young (e.g., ages 20-30) people, both genders and all races.

References:

  1. Brot C, Jorgensen NR, Sorensen OH. The influence of smoking on vitamin D status and calcium metabolism. Eur J Clin Nutr. Dec 1999;53(12):920-6.
  2. Kimball S, Vieth R, Dosch HM, et al. Cholecalciferol plus calcium suppresses abnormal PBMC reactivity in patients with multiple sclerosis. J Clin Endocrinol Metab. Sep 2011(96(9)):2826-34.

 

Study #3: Determine relationship of 25(OH)D and 1,25(OH)2D in patients with autoimmune and chronic illnesses.

Premise: Many studies have established that 25(OH)D is often low in patients with autoimmune and other chronic diseases. However, 1,25(OH)2D is rarely measured in these studies. Blaney et al. [1] found elevated 1,25(OH)2D in 85% of 100 patients with non-granulomatous, autoimmune diseases; without hypercalcemia.

Action: Measure both 25(OH)D and 1,25(OH)2D levels in patients with diagnoses and/or symptoms of autoimmune and chronic illnesses.

Reference:

  1. Blaney GP, Albert PJ, Proal AD. Vitamin D metabolites as clinical markers in autoimmune and chronic disease. Ann N Y Acad Sci. Sep 209;1173:384-90.

 

Study #4: Determine the effect of olmesartan on elevated 1,25(OH)2D when administered at frequent intervals.

Premise: Limited but intriguing data indicates that olmesartan reduces elevated 1,25(OH)2D when administered every six hours.

Action: Expand the existing data in a study of patients with elevated 1,25(OH)2D by measuring 1,25(OH)2D two to four weeks following introduction of frequent olmesartan dosing.

 

Study #5: Determine the efficacy of treating patients with autoimmune and chronic illnesses with frequent-dose olmesartan and low-dose, pulsed antibiotics.

Premise: Natural experiments and subjective data indicate symptom improvement with frequent-dose olmesartan and low-dose, pulsed antibiotics.

Action: Collect hard data and compile case reports of patients undergoing this type of treatment on a long-term basis.

 


New Scientific Articles  

 

The immune system and the microbiota mutually interact to maintain homeostasis in the intestine. However, components of the microbiota can alter this balance and promote chronic inflammation, promoting intestinal tumor development.

 

 

The Role of Vitamin D in Atherosclerosis Inflammation Revisited: More a Bystander than a Player?
In contrast to the causal assumption, we hypothesize that the decreased vitD levels, seen in patients with CVD and chronic immunopathologies is secondary to inflammation and not as pathophysiologically relevant as currently suggested.

     

 

Quotes 

 

"Doctor B. was pleased with my state of health. I'm maintaining my size 14 skinnier self since more than a year ago. Blood pressure and pulse are excellent. Had a very mild crackle in lungs, but I hadn't noticed it. I usually notice it." Sue

 

"My improvement is continued and I'm looking forward to a much merrier Christmas!!" Emmley


 

Recovery Reports 

 

We are contacted daily by people with chronic illnesses who are looking for an effective treatment. Many ask us to provide evidence of efficacy in the form of statistics or stories. If you have recovered your health or had significant symptom improvement with Inflammation Therapy, please help us 'pay it forward' by telling your story. We will post it in the public section of our website to encourage others. Any report, short or long, with or without objective data (e.g., lab results, imaging reports) would be helpful. Please email your story to us. Thank you!