Vitamin D Supplementation and Cardiovascular Disease
In recent years, dietary supplements containing vitamin D have been frequently consumed in the hope that it might protect against cardiovascular disease. However, there is no conclusive evidence that vitamin D supplementation affords protection against heart disease.1,2
A randomized, placebo-controlled study, done at Rockefeller University in New York, found vitamin D supplementation failed to improve lipid profiles and elevated 25-D was associated with carotid and aorta artery plaque in a 2012 study.3,4
At a symposium sponsored by the American College of Rheumatology Dr. Lenore Buckley (professor of internal medicine at Virginia Commonwealth University) commented on the 2012 study:
One of these concerns is that not all of the extra calcium absorption promoted by boosting vitamin D is going into bone to prevent fractures. Some of it may actually be taken up by atherosclerotic plaque, increasing the risk of cardiovascular events. The question we have to ask is: What does that low serum vitamin D level mean? Is it the thing that predisposes, or is it somehow a byproduct of illness?5
Regarding supplementation to prevent cardiovascular disease, Dr. Whayne (Professor of Medicine-Cardiology, Gill Heart Institute, University of Kentucky, Lexington, KY) concluded that potential benefit of supplementation must be weighed against the current absence of definitive outcomes studies.6
1. Pittas AG, Chung M, Trikalinos T, et al. Systematic review: Vitamin
D and cardiometabolic outcomes, Ann Intern Med. Mar 2010;152(5).
2. McGreevy C, Williams D. New insights about vitamin D and
cardiovascular disease: a narrative review. Ann Intern Med. Dec
2011;155(12):820-6.
3. Ponda MP, Dowd K, Finkielstein D, Holt PR, Breslow JL. The short-
term effects of vitamin D repletion on cholesterol: a randomized,
placebo-controlled trial. Arterioscler Thromb Vasc Biol. Oct 2012;32
(10):2510-5.
4. Freedman BI, Wagenknecht LE, Hairston KG, et al. Vitamin D,
adiposity, and calcified atherosclerotic plaque in African-Americans.
J Clin Endocrinol Metab. Mar 2010;95(3):1076-83.
5. Skepticism Mounts on Need for Vitamin D Supplementation.
HighBeam Research. Feb 15, 2010.
6. Whayne Jr TF. Vitamin D: popular cardiovascular supplement but
benefit must be evaluated. Int J Angiol. Jun 2011;20(2):63-72.