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Annual Patient Workshop
Save the date:
Sunday
February 16, 2014
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Therapy Tip
Vitamin D status is commonly determined by measuring the level of 25-D which, presumably, reflects the levels of other D metabolites. This measurement does not, however, provide enough information to accurately assess vitamin D endocrine function. Measurement of both the active metabolite (1,25-D) and its precursor (25-D) is essential to diagnose dysregulated vitamin D metabolism.
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Recovery Reports
We are contacted daily by people with chronic illnesses who are looking for an effective treatment. Many ask us to provide evidence of efficacy in the form of statistics or stories. If you have recovered your health or had significant symptom improvement with Inflammation Therapy (or a similar treatment), please help us 'pay it forward' by telling your story. We will post it in the public section of our website to encourage others. Any report, short or long, with or without objective data (e.g., lab results, imaging reports) would be helpful. Please
send your story to
our email .
Thank you!
To see the latest recovery reports,
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CIR Library Access
Access to our free, extensive, easy-to-read Library of Information
(see this sample page)
and Physicians' Reference Library is available to anyone, without enrollment in our counseling program. If you're interested in using this resource, please send a request to our email
address along with your doctor's name and fax number (in the US or Canada) or his/her email address, so we can notify your doctor that you have access to this information.
A list of the articles in our libraries is available at this link.
Physicians may use CIR libraries even if they don't have a patient enrolled in our counseling program. Interested medical practitioners should contact CIR and ask to register.
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Have you enjoyed this newsletter?
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Greetings!
We're pleased to add an article to our library to help explain the complicated issue of vitamin D endocrine dysfunction. Chronic illness means the immune system is dysfunctional and vitamin D plays a pivotal role.
By understanding the D metabolite tests, you can avoid unintentional immune suppression. Its hormone receptor transcribes the genes to keep chronic infections at bay.
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About Inflammation Therapy
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How Vitamin D Metabolism Affects Autoimmune and Inflammatory Diseases
In an effort to clarify the many issues involving vitamin D and chronic inflammation, we have created an article titled "How Vitamin D Metabolism Affects Autoimmune and Inflammatory Diseases" which reviews basic vitamin D function, explores the controversy surrounding vitamin D recommendations, examines the causes of vitamin D deficiency, critiques the rationale for vitamin D supplementation, explains vitamin D toxicity, proposes a pathogenesis for impaired vitamin D status, and summarizes a strategy to restore normal vitamin D metabolism. The abstract is reprinted here and the essay may be accessed by clicking on this link.
Abstract
Vitamin D has received much attention in recent years because studies found an association between low serum 25-hydroxyvitamin D (hereafter referred to as 25-D) levels and some disease states. This has caused a heated debate among experts regarding the definition of vitamin D deficiency and the amount of vitamin D necessary for health. Concerns about vitamin D deficiency merit a closer look at the current method of determining vitamin D status. Because the serum level of 25-D doesn't always reflect the level of the hormone 1,25-dihydroxyvitamin-D (hereafter referred to as 1,25-D), measuring both of these vitamin D metabolites may provide a better assessment. An analysis of the active metabolite, as well as its inactive precursor, may reveal low 25-D in the presence of elevated 1,25-D and lead to a diagnosis of abnormal vitamin D endocrine function. The definition of Vitamin D deficiency needs re-evaluation in view of the fact that low serum 25-D is often found in healthy persons. New research contradicts current explanations of vitamin D deficiency and studies used as evidence of the need for vitamin D supplementation are inconclusive. It's theorized that low vitamin D is a consequence of an inflammatory process and increasing 25-D via supplementation could have negative effects. A bacterial etiology pathogenesis of chronic inflammation appears to provide a rationale for an inflammatory disease process that causes low serum 25-D. There are indications treatment directed at eradicating persistent intracellular infection can correct dysregulated vitamin D metabolism and restore vitamin D metabolites to normal levels.
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This meta-analysis study found that beyond blood levels of 21 ng/ml, any additional increase in serum 25-D was associated with an increase in CRP (C-reactive protein), a factor linked to stiffening of the blood vessels and an increased risk of cardiovascular problems. The team's research also suggests a link between excess vitamin D and elevated homocysteine levels, another danger sign for cardiovascular disease.
Relationship between 25-Hydroxyvitamin D and All-cause and Cardiovascular Disease Mortality
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About Chronic Illness Recovery
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Analysis of D-metabolites lab results
Conflicting information about vitamin D has prompted puzzled patients (and practitioners) to ask us what the results of D-tests mean, especially if the numbers are labeled as vitamin D deficient. In 2006, the Merck Manual listed 25-40 ng/ml as the normal 25-D range. Recently, this range has skyrocketed to 30-74 ng/ml. Laboratory reference ranges for serum 25-D levels have long been based upon average values from populations of healthy individuals but many people are now supplementing with vitamin D. For this reason, the Institute Of Medicine has stated that lab ranges may be skewed and numbers overestimated. Similarly, lab ranges for 1,25-D (e.g., 18-72 pg/ml) have been skewed high by the presence of patients with unrecognized dysregulated vitamin D metabolism.
If you would like us to provide a written analysis of D-tests (and other lab markers of inflammation), please send us a copy of the lab report via email attachment or fax. This documentation can clarify the existence of dysregulated vitamin D endocrine function, add validity to a diagnosis of chronic systemic inflammation and confirm the need for Inflammation Therapy.
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| Quotes | |
This therapy has been a miracle for me, and I was lucky to find it when I did. ~Anne
By the grace of God I found IT and this treatment saved my life, 5 years ago I was headed for a permanent trach, disability and death. My former doctor told me that he would do everything he could to keep me comfortable...well I'm still here with no trach, no disability and definitely living a full rich life. ~ Debra
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| HONcode | |
The Internet has become an important communication tool but it isn't always easy to tell which information is reliable. When it comes to your health, it's important to be sure you're accessing a credible source. Health On the Net Foundation has certified that the Chronic Illness Recovery website and forum conform to the principles of the HONcode for the dissemination of trustworthy health information for patients and professionals.
The HON seal on our website is your assurance that we're providing medical information you can trust.
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Volunteers who have a diagnosis of autoimmune or inflammatory disease or are chronically ill but who are not being treated with Inflammation Therapy, the Marshall Protocol or the Stillpoint Protocol are needed to be in the control group of our long-term clinical study.
If you meet these criteria and would like to take part in this project (which will only take a few minutes each month), please contact us at our email address.
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