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Annual Patient Workshop
Save the date:
Sunday
February 16, 2014
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Therapy Tip
Depending on the dose, Minocycline's actions can be antibacterial or anti-inflammatory. Inflammation Therapy uses this information to guide the adjustment of Minocycline dose and schedule to provide
the appropriate effect
and keep herxing
tolerable. | |
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Recovery Reports
We are contacted daily by people with chronic illnesses who are looking for an effective treatment. Many ask us to provide evidence of efficacy in the form of statistics or stories. If you have recovered your health or had significant symptom improvement with Inflammation Therapy (or a similar treatment), please help us 'pay it forward' by telling your story. We will post it in the public section of our website to encourage others. Any report, short or long, with or without objective data (e.g., lab results, imaging reports) would be helpful. Please
send your story to
our email .
Thank you!
To see the latest recovery reports,
click here. | |
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CIR Library Access
Access to our free, extensive, easy-to-read Library of Information
(see this sample page)
and Physicians' Reference Library is available to anyone, without enrollment in our counseling program. If you're interested in using this resource, please send a request to our email
address along with your doctor's name and fax number (in the US or Canada) or his/her email address, so we can notify your doctor that you have access to this information.
A list of the articles in our libraries is available at this link.
Physicians may use CIR libraries even if they don't have a patient enrolled in our counseling program. Interested medical practitioners should contact CIR and ask to register. | |
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Survey
Volunteers who have a diagnosis of autoimmune or inflammatory disease or are chronically ill but who are not being treated with Inflammation Therapy, the Marshall Protocol or the Stillpoint Protocol are needed to be in the control group of our long-term clinical study. If you meet these criteria and would like to take part in this project (which will only take a few minutes
each month), please
contact us at our
email address. | |
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CIR is an IRS-recognized 501(c)3 non-profit charitable organization.
Donate to CIR
in support of our educational and research efforts.
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Contact Us | |
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you may phone us toll free from anywhere in the US and Canada
1-888-846-2474
Skype
Chronic.Illness.Recovery
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Have you enjoyed this newsletter?
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Greetings!
People who are searching the Internet for answers to their health care problems are usually grateful when others reach out and share valuable information. It's difficult for some to find Chronic Illness Recovery and we rely on you to tell others who may be struggling, professional help is available.
We strive to keep the information on our website up to date and we're happy to answer questions via email. Physicians appreciate our experienced analysis of vitamin D-metabolites results and our large resource of scientific papers.
Thanks for helping your fellow sufferers; knowing you've shared another healthcare option with someone in need is a very good feeling.
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About Inflammation Therapy | |
Zithromax safety
Azithromycin (Zithromax) is a macrolide commonly used for its antibacterial activity in both children and adults, and usually prescribed during the course of Inflammation Therapy. On March 12, 2013, the FDA issued a warning about Zithromax when it's taken by patients with certain conditions (e.g., existing QT prolongation, bradycardia, low blood levels of magnesium or potassium). [1.] In the study the warning was based on, the risk of cardiovascular death was 1 in 4,100 among high-risk patients and the duration of increased risk corresponded to the duration of Zithromax exposure. Risk is limited to a small well-defined population and the risk in that group is very small. [2.]
The adverse reactions seen in the study may have been due to a Herxheimer effect in patients with undiagnosed systemic inflammation. Zithromax is very effective at targeting intracellular bacteria but it has a long tissue half-life so it needs to be dosed carefully to avoid intolerable Herxheimer reactions. The standard dose of 500mg daily is far greater than the maximum dose used with Inflammation Therapy but patients on Inflammation Therapy who are in the high risk group [2.] should be aware that even the small initial dose of Zithromax could provoke this type of Herxheimer reaction.
Clinical experience indicates the need for prolonged therapy to maintain beneficial effects in certain conditions. [3.] Low-dose, pulsed Zithromax is recommended for long-term use on Inflammation Therapy. Two randomized, placebo-controlled studies reported that Zithromax treatment produced no adverse effects in children or adults with cystic fibrosis. [4.] [5.] In a third study with safety as a primary end point, most adverse events were of mild-to-moderate intensity. [3.]
In controlled studies involving patients with cystic fibrosis treated for up
to 6 months, Zithromax did not increase the risk of bacterial resistance. [3.] [4.] [5.] Zithromax also has anti-inflammatory properties [6.] that often help patients tolerate the unavoidable Herxheimer reactions during Inflammation Therapy.
We believe that Zithromax, as used on Inflammation Therapy, is safe for most patients and essential to the recovery process.
[1.] FDA Drug Safety Communication: Azithromycin (Zithromax or Zmax) and the risk of potentially fatal heart rhythms., March 18, 2013.
[2.] Ray WA, Murray KT, Hall K, et al. Azithromycin and the risk of cardiovascular death. New England Journal of Medicine. 366:1881-1890., 2012.
[3.] Saiman L, Marshall BC, Mayer-Hamblett N, et al. Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial. Journal of the American Medical Association. 290:1749-56., 2003.
[4.] Wolter J, Seeney S, et al. Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: a randomised trial. Thorax. 57:212-16., 2002.
[5.] Equi A, Balfour-Lynn IM, et al. Long term azithromycin in children with cystic fibrosis: a randomised, placebo-controlled crossover trial. Lancet. 360:978-84., 2002.
[6.] Kanoh S, Rubin BK. Mechanisms of Action and Clinical Application of Macrolides as Immunomodulatory Medications. Clinical Microbiology Reviews. July, 23(3):590-615., 2010.
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Minocycline ameliorates LPS-induced inflammation in human monocytes by novel mechanisms including LOX-1, Nur77 and LITAF inhibition.
"Our results in primary human monocytes contribute to explain the profound anti-inflammatory and protective effects of minocycline in cardiovascular and neurological diseases and may have direct translational relevance."
The world pandemic of Vitamin D deficit could possibly be explained by cellular inflammatory response activity induced by the renin angiotensin system.
"Changes in RAS activity and activation of VDR seem to be inversely related, making it possible to speculate that both systems could have a feedback relationship. In fact, the pandemic of VitD deficiency could be the other face of increased RAS activity, which could potentially cause a lower activity or lower levels of VitD. Finally, from a therapeutic point of view, the combination of RAS blockade and VDR stimulation appears to be more effective than each one used individually."
"Since high concentrations of 25-hydroxyvitamin D can bind the vitamin D receptor and can induce transcription, 25-hydroxyvitamin D is likely responsible for toxicity of vitamin D excess." |
About Chronic Illness Recovery | |
How do I enroll in your counseling program?
To enroll in the Chronic Illness Recovery counseling program, send us an email (see sidebar) and ask for an Enrollment Form.
You will be asked for your doctor's email address or fax number so we can send him/her a letter of explanation about the CIR counseling program and the professional forms to sign. When we've received all the necessary documents, any applicable fee and reviewed the enrollment form, you'll be notified of acceptance and registered at the Website/Forum where you will post progress reports and ask questions.
How long does this process take?
The enrollment process can be accomplished very quickly - it all depends on the length of time it takes for the four necessary documents to be returned (and any applicable fee to be made). Some patients and doctors return the forms the same day they're received and others need more time to accomplish this task.
Should I wait to enroll before starting inflammation therapy?
Because it's important to get off to a good start we recommend completing the enrollment process before starting therapy so that you can ask questions about the medications and we can determine that you understand the process. Then if you have problems initially you'll be able to turn to the CIR Nurses for help.
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| Quotes | |
"3 years ago, I was going through hell and back - tears come to me when I remember that time of my life, before IT. I become very emotional when I think of those uncertain days. I was truly alone, with short doctor visits, and people telling me "just relax, you'll feel better". Well I couldn't breathe back then, on 3 inhalers that were barely helping me through the day. I felt my body was attacking me from inside. Anyway it has been slow for me but I feel better with every week that goes by in IT. I'm in control and I have wonderful help, I couldn't be doing this without you." Jean
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| HONcode | |
The Internet has become an important communication tool but it isn't always easy to tell which information is reliable. When it comes to your health, it's important to be sure you're accessing a credible source. Health On the Net Foundation has certified that the Chronic Illness Recovery website and forum conform to the principles of the HONcode for the dissemination of trustworthy health information for patients and professionals. The HON seal on our website is your assurance that we're providing medical information you can trust.
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