The etiology of Parkinson's Disease (PD) involves both genetic and environmental factors where inflammation plays a key role. Patients with PD have increased levels of inflammatory cytokines, however it is unclear if inflammation is the cause or result of neurodegeneration. Scientists from the Rush University Medical Center in Chicago recently employed an inflammation-driven model of PD in mice to investigate the utility of lipopolysaccharide-binding protein (LBP) as a biomarker for endotoxin-induced inflammation. Their results showed a significantly reduced amount of LBP in PD patients, indicating an increase of circulating endotoxin due to bacterial translocation. These results establish LBP as a valuable biomarker for identifying PD.

Abnormal lipopolysaccharide binding protein as a marker of gastrointestinal inflammation in Parkinson's Disease
BioDtech has products for all of your endotoxin needs
BioDtech products are designed to more accurately detect endotoxin and remove it from protein and DNA samples. Our detection products have been used to measure previously undetectable levels of endotoxin which could cause activation of the immune system. Additionally, our endotoxin removal media is effective for a wide range of sample types and conditions. We routinely observe 99% endotoxin removal with over 90% product recovery.
DETECTION
EndoPrep and ESP increase endotoxin detection accuracy in samples ranging from protein solutions to blood products.
REMOVAL
Our EndoBind-R family of affinity media efficiently removes endotoxin with low product loss. Includes standard and single-use options.
NEUTRALIZATION
Sushi Peptide is available for neutralization, leaching studies and Factor C detection. A rhodamine version is available for labeling endotoxin.

For further questions, including product details, technical information or ordering options, feel free to contact me directly at any time. You can reach me via phone (205-414-7586), fax (205-414-7400), through our WEBSITE or through direct E-MAIL. You can also connect with me on LinkedIn.

Sincerely,
Keith Champion, Ph.D.
Director of Operations
BioDtech, Inc.   
 


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