Dear Dr. , The role of gut microbiota, along with the corresponding translocation of endotoxin into circulation, has been demonstrated for many diseases including Crohn's Disease, ulcerative colitis, HIV and diabetes. A recent publication in the Journal of Clinical Gastroenterology has extended this to liver disease. Using several different mouse models to simulate liver disease, they found significant differences in the microbiome compared to healthy control mice. Several mechanisms for this link were explored, including an increase in gut permeability leading to an increase in circulating endotoxin. Given that Toll-like receptors are required for sensitivity to liver fibrosis, and the role that endotoxin plays in other inflammatory diseases, this is an especially attractive possibility. Role of Gut Microbiota in Liver Disease
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BioDtech has products for all of your endotoxin needs
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BioDtech products are designed to more accurately detect endotoxin and remove it from protein and DNA samples. Our detection products have been used to measure previously undetectable levels of endotoxin which could cause activation of the immune system. Additionally, our endotoxin removal media is effective for a wide range of sample types and conditions. We routinely observe 99% endotoxin removal with over 90% product recovery.
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EndoPrep and ESP increase endotoxin detection accuracy in samples ranging from protein solutions to blood products.
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Our EndoBind-R family of affinity media efficiently removes endotoxin with low product loss. Includes standard and single-use options.
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Sushi Peptide is available for neutralization, leaching studies and Factor C detection. A rhodamine version is available for labeling endotoxin.
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For further questions, including product details, technical information or ordering options, feel free to contact me directly at any time. You can reach me via phone (205-414-7586), fax (205-414-7400), through our WEBSITE or through direct E-MAIL. You can also connect with me on LinkedIn. Sincerely, Keith Champion, Ph.D. Director of Operations BioDtech, Inc. |
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