One of the most predictive indicators of mortality in HIV is the level of systemic inflammation caused by endotoxin escaping the GI tract through a process known as bacterial translocation. Several recent publications, including one from Tufts Medical Center, have shown significant differences in the microbiota of HIV-infected individuals. These changes correlate with known markers of systemic immune activation, indicating that changes in the microbiota contribute to intestinal permeability and bacterial translocation.

Intestinal Microbiota, Microbial Translocation, and Systemic Inflammation in Chronic HIV Infection

Scientists at BioDtech, Inc. have measured previously undetectable levels of endotoxin which could cause activation of the immune system.  BioDtech products are designed to more accurately detect endotoxin and remove it from proteins and DNA.