It has been well established that HIV infection alters intestinal barrier integrity leading to bacterial translocation and a corresponding immune response due to endotoxin exposure.  Additionally, it has been observed that undernourishment significantly increases the mortality rate in HIV-infected adults.  Using serum markers, a recent study from Vanderbilt University shows that this is a result of an even more heightened level of bacterial translocation and endotoxin exposure.

A 12 Week Longitudinal Study of Microbial Translocation and Systemic Inflammation in Undernourished HIV-Infected Zambians Initiating Antiretroviral Therapy

BioDtech offers solutions for both endotoxin detection and removal.  This includes our ESP technology, a method for accurate endotoxin detection in blood plasma products.

BioDtech, Inc. offers many products to assist in both removal and detection of endotoxin. 

EndoBind-R™ is an affinity chromatography media designed to remove endotoxin from aqueous solutions.  The ligand is highly specific for endotoxin resulting in high detoxification and low product loss.

EndoPrep™ is a sample preparation kit used in conjunction with LAL or rFC assays.  It removes the interfering effects of proteins that can mask endotoxin or inhibit enzymatic assays thus providing more accurate  endotoxin quantitation.