It has previously been demonstrated that biological effects of alcoholism, including liver disease, are partially due to increased bacterial translocation due to a deterioration of gut integrity.  A recent report from scientists at the University of Massachusetts demonstrates that bacterial-induced inflammation can occur in healthy individuals with single episodes of binge drinking:

Acute Binge Drinking Increases Serum Endotoxin and Bacterial DNA Levels in Healthy Individuals

Similarly, another publication from the University of Texas indicated that endotoxin-induced inflammation promotes alcohol consumption:

Activation of Inflammatory Signaling by Lipopolysaccharide Produces a Prolonged Increase of Voluntary Alcohol Intake in Mice

Taken together, these results suggest that a single episode of binge drinking could result in endotoxin-induced inflammation and promote the desire for more alcohol.

Scientists at BioDtech, Inc. have measured previously undetectable levels of endotoxin which could cause activation of the immune system.  BioDtech products are designed to more accurately detect endotoxin and remove it from proteins and DNA.