A hallmark in patients with neurological disorders, such as Alzheimer's Disease (AD) and multiple sclerosis (MS), is an elevated level of pro-inflammatory cytokines.  This is a result of increased plasma endotoxin leading to macrophage activation and a persistent low-grade inflammatory response.  Two recent articles have further implicated the role of endotoxin in these diseases.

A recent publication from Italy has shown that endotoxin is important in the aggregation of amyloid fibrils, a significant reaction in the progression of AD:

Can a Bacterial Endotoxin be a Key Factor in the Kinetics of Amyloid Fibril Formation?

A report from the UK has shown that endotoxin-induced macrophage activation in MS lesions produce cytokines that cause axonal injury:

Systemic Inflammation Induces Axon Injury During Brain Inflammation

Both of these reports highlight the devastating effects of bacterial infection in patients with neurological disorders and the importance of monitoring endotoxin-associated inflammation even in the absence of "overt clinical signs".

BioDtech, Inc. offers many products to assist in both removal and detection of endotoxin. 

EndoBind-R™ is an affinity chromatography media designed to remove endotoxin from aqueous solutions.  The ligand is highly specific for endotoxin resulting in high detoxification and low product loss.

EndoPrep™ is a sample preparation kit used in conjunction with LAL or rFC assays.  It removes the interfering effects of proteins that can mask endotoxin or inhibit enzymatic assays thus providing more accurate  endotoxin quantitation.