The FDA has established allowable clinical levels of endotoxin. However, in mice chronic exposure to subclinical levels of endotoxin results in increased mortality, most likely due to cardiac fibrosis since cardiac cells express Toll-4 receptors. This increase in mortality occurs with minimal effects that do not persist after exposure and highlights the need for accurate and sensitive endotoxin detection in all therapeutics. This work, by the cardiology group from the UC San Diego School of Medicine, was recently published in PLOS One:
Recurrent Exposure to Subclinical Lipopolysaccharide Increases Mortality and Induces Cardiac Fibrosis in MiceScientists at BioDtech, Inc. have measured previously undetectable levels of endotoxin which could cause activation of the immune system. BioDtech products are designed to more accurately detect endotoxin and remove it from proteins and DNA.
