News from TRIPLL
Pain Management Developments for Older Adults with Pain
A recent article published in Medicine addressed research gaps in the area of pain management among older adults. The author determined that, "the assessment and management of pain in this age group are poorly practiced, particularly among those with dementia." The author also found that complementary and alternative pain management therapies for older adults lacked evidence-based support, stating " there are alternative approaches such as psychological therapies and self management strategies, and adjuvant treatments such as transcutaneouselectrical nerve stimulation or acupuncture, which have a relatively small body of evidence supporting their use."
The Relationship Between Pain and Disruptive Behaviors in Older Adults with Dementia
In BMC Geriatrics a recent study examined the relationships between pain and disruptive behaviors among older adults with dementia. The authors analyzed the Florida state Minimum Data Set (MDS 2.0) on long-term care, which consisted of data on nursing home residents with dementia aged 65 and older. The data set was used to examine "pain, wandering, aggression, agitation, cognitive impairment, activities of daily living impairments, and demographic characteristics." The authors conclude that the relationships between pain and disruptive behaviors were influenced by specific characteristics, "pain is positively correlated with disruptive behaviors that do not involve locomotion (e.g., aggression and agitation), but negatively related to disruptive behaviors that are accompanied by locomotion (e.g., wandering)."
A Systematic Review on Prescribing Opioids in Older People
A systematic review published in Mauritas reviewed the "current concepts, evidence and controversies" surrounding opioid use among older adults. Articles selected for the review addressed issues of "pain assessment, screening for substance abuse potential, starting treatment, monitoring effectiveness of pain control, and managing opioid-associated side-effects." The authors determined that "the challenge of prescribing opioids in older adults is to understand the factors involved in making appropriate choices and monitoring the beneficial effects of pain relief while managing the side-effects," and that "more research is needed to validate the safety, efficacy and targeted appropriate use of opioid analgesics in older people, especially those 80-years and older."
New Evidence and Strategies for Prescribing Opiods for Chronic Pain
The American Journal of Medicine featured a study that sought to identify new evidence and strategies for prescribing opiods for chronic pain conditions among older adults. The authors identified strategies that suggested opioid use for patients with severe back pain, recommended opioid therapy for older adults at higher risk for NSAID related adverse effects, and asked health professionals to consider opioid rotation for patients that were unresponsive to opioid therapy. The authors suggest that "opioids are not appropriate for all patients; rather, a differential diagnosis, consideration of other comorbidities, and the potential for opioid-related adverse effects and substance abuse are required to confirm the value of opioid treatment for each individual."
The following list includes upcoming seminars, meetings, and conferences that focus on aging, pain, or general research methods
March Work-in-Progress Seminar
TRIPLL will host a WIP seminar on March 20 2013. To participate, please contact Marcus Warmington at firstname.lastname@example.org if you have any questions or would like to participate in future WIPs.
Survey Design Made Simple: Tips for Conducting a Local Survey
Monday, March 11| 3:00pm - 4:00pm EST
Presenter: Karl Pillemer, PhD, Professor of Human Development, Cornell University, and Professor of Gerontology in Medicine, Weill Cornell Medical College
Overview: Many organizations conduct surveys to assess local needs, shed light on client satisfaction, or to gather other kinds of knowledge from a specified group of people. This webinar will provide a non-technical overview of some principles of good survey design that participants can put into use. Dr. Pillemer will look at common mistakes that can bias the outcome of surveys, as well as describing the steps in conducting a successful survey.Movement & Meditation to Ease Chronic Pain
When living with pain, it is easy to find yourself avoiding daily activities, opting to stay still and avoiding unnecessary movement. Unfortunately, not moving your muscles and joints often leads to more pain. Let's get moving! Join us for this gentle class that will utilize the movements of yoga and stretching in addition to breathing awareness and meditation to help ease stiffness, aches and pains.
For more information: www.hss.edu/pped or (212) 606-1613.
The Faculty Development Collaborative Program in Geriatrics
is a training program designed to enhance the knowledge and skills of health professions faculty in inter-professional teaching, leadership, project development and program implementation in geriatrics. This course will prepare health professions faculty from multiple disciplines to utilize contemporary evidence-based educational strategies, inter-professional team approaches, and innovative evaluation processes in teaching collaborative patient- centered care.
AAGP 2013 Annual Meeting The American Association for Geriatric Psychiatry (AAGP) is the only national association that has products, activities and publications, which focus exclusively on the challenges of geriatric psychiatry. Practitioners, researchers, educators, students, the public-anyone interested in improving the mental health of the elderly-have relied on AAGP since 1978 as the key driver for progress for elderly mental health care. Whether you want to advance your career, engage the research community, or shape how science and society treat the elderly, AAGP has the right resources to help you.
LA Live - Marriott,
March 14-17, 2012
Pain in Aging (R01)
Program Announcement (PA) Number: PAR-10-282
"This FOA encourages Research Project Grant (R01) applications from institutions/organizations that propose to study pain from an aging perspective, including studies of older populations, studies of age differences and age-related changes in pain processes and experiences, and studies of pain treatment and management in older adults. This FOA particularly encourages studies on 1) mechanisms and predictors of pain experience in aging, 2) development and evaluation of pain assessment tools for older adults or older model organisms, and 3) development and evaluation of pain management strategies in older adults, with particular attention to the challenges associated with treating pain in patients with multiple morbidities. Studies may address a variety of approaches and outcomes including biological (i.e., genetic, molecular, neurobiological), clinical, behavioral, psychological, and social factors. Both animal models (especially aged animals) and human subjects are appropriate for this FOA."
Pilot and Feasibility Clinical Research Grants in Arthritis and Musculoskeletal and Skin Diseases (R21)
Program Announcement (PA) Number: PAR-10-282
"This FOA, issued by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health, encourages exploratory/developmental clinical research related to the prevention or treatment of arthritis and musculoskeletal and skin diseases, conditions, and/or injuries. The Pilot and Feasibility Clinical Research Grants Program is designed to allow initiation of exploratory, short-term clinical studies, so that new ideas may be investigated without stringent requirements for preliminary data. The short-term studies should focus on research questions that are likely to gather critical preliminary data in support of a future, planned clinical trial. They can include testing new or prevention strategies, a new intervention, or unique combinations of therapies. A high priority is the use of such studies to help stimulate the translation of promising research developments from the laboratory into clinical practice."
Mayday Fund of New York
"The Mayday Fund is dedicated to alleviating the incidence, degree, and consequence of human physical pain.
The Mayday Fund's current grant-making targets are projects that result in clinical interventions to reduce the toll of physical pain, pediatric pain, pain in non-verbal populations, and pain in the context of emergency medicine. Mayday will also continue to be proactive in its commitment to promote networking between veterinary and human medicine, especially in an effort to inform measurements of pain in non-verbal populations. Finally, the trustees of the Mayday Fund wish to be nimble enough to respond as special opportunities present themselves. Grants are made only to public charities and educational institutions officially recognized as such by the IRS. The Mayday Fund concentrates its activities in the United States. On occasion, grants have been made to Canadian organizations when the project has an effect that reaches beyond Canada. Grants cannot be made to individuals."
Applications are continuous and no specified due date is applied.
Translational Research at the Aging/Cancer Interface (TRACI) (R01)
Program Announcement (PA) Number: PA-12-136
This Funding Opportunity Announcement (FOA) encourages translational research proposals in the overlapping areas of human aging and cancer, linking basic and clinical research relevant to the care of older cancer patients through both bench-to-bedside and bedside-to-bench approaches. Ultimately, information from the research supported by this initiative should improve the health and well-being of elderly patients at risk for, or diagnosed with, cancer and decrease the functional impairment and morbidity associated with cancer in this population.
T1 Translational Research: Novel interventions for prevention and treatment of age-related conditions (R21)
Program Announcement (PA) Number: PAS-11-280
This funding opportunity announcement (FOA) encourages exploratory/developmental R21 research projects to accelerate the pace of development of novel therapeutics involving biologics, pharmacological and non-pharmacological approaches for preventing and treating key health issues affecting the elderly. For the purposes of this FOA, T1 translational research on aging is defined as the application of basic and clinical biomedical findings towards the development of new strategies for prevention and treatment of age-related pathologies. For projects proposing basic research that is being conducted in animal models, the potential to treat a clinical age-related pathology must be clearly stated in the proposal. Direct relevance of the data to a clinical aging condition must be established and clearly stated in the application.
Mechanism Mediating Osteoarthritis in Aging
Translational Research to Help Older Adults Maintain their Health and Independence in the Community (R01)
Program Announcement (PA) Number: PA-11-123
The National Institute on Aging (NIA) and the Administration on Aging (AoA) invite applications using the R01 award mechanism for translational research that moves evidence-based research findings towards the development of new interventions, programs, policies, practices, and tools that can be used by community-based organizations to help elderly individuals remain healthy and independent, and living in their own homes and communities. The goal of this FOA is to support translational research involving collaborations between academic research centers and community-based organizations with expertise serving the elderly (such as city and state health departments, city/town leadership councils, and Area Agencies on Aging) that will enhance our understanding of practical tools, techniques, programs and policies that communities across the nation can use to more effectively respond to needs of their aging populations.
Program Announcement (PA) Number: PA-12-018
"This Funding Opportunity Announcement (FOA) issued by the National Institute on Aging (NIA) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) invites applications on research employing genetically defined and modified mouse models, other animal models such as dogs and monkeys or archived human joint tissues to explore the biological mechanisms underlying osteoarthritis. Osteoarthritis is a significant problem in the elderly population, and a major contributor to mobility limitations that are endemic in this population and, therefore, is an important element in the research missions of NIA and NIAMS. Inflammatory processes are evident in advanced stages of osteoarthritis, and are likely to be major contributors to the chronic pain that is the most common symptom of the condition. However, for the purpose of this announcement, osteoarthritis is distinguished from other joint diseases, such as rheumatoid arthritis, in which inflammation arising from autoimmunity is the primary cause of tissue damage. The root causes of joint degeneration in osteoarthritis remain unclear. Research efforts in the past have focused primarily on the more advanced stages of osteoarthritis, but relatively little is understood about the initial changes triggering disease etiology and early progression. This FOA is intended to encourage and accelerate the characterization of new or underutilized models and the testing of hypotheses that will lead to an improved understanding of the mechanisms mediating osteoarthritic progression."
Notice of Intent to Publish a Funding Opportunity Announcement (FOA) on Multidisciplinary Studies in HIV/AIDS and Aging (R03)
Notice Number: NOT-AG-12-004
"The National Institute on Aging (NIA) announces a trans-NIH Funding Opportunity Announcement (FOA) on Multidisciplinary Studies in HIV/AIDS and Aging. This FOA will encourage applications proposing to study HIV infection, HIV-associated conditions, HIV treatment, or biobehavioral or social factors associated with HIV/AIDS in the context of aging and/or in older adults. The research areas encouraged in this FOA are based, in part, on the recommendations of the Working Group on HIV and Aging convened by the NIH Office of AIDS Research. These areas include, but are not limited, to the following:
* Cellular and molecular mechanisms of HIV in aging
* Biomarkers or clinical indices of HIV-associated pathology
* HIV-Associated Non-AIDS (HANA) conditions / Co-morbidities
* HIV-Associated Neurocognitive Disorders (HAND)
* Intervention studies (prevention or treatment)
* Social, behavioral, and mental health studies
The FOA is expected to be published in Spring 2012 with non-standard receipt dates beginning in Summer 2012. Multiple other NIH Institutes and Centers are expected to participate."
Please direct all inquiries to:
Basil Eldadah, MD, PhD
Division of Geriatrics and Clinical Gerontology
National Institute on Aging
7201 Wisconsin Ave, Suite 3C307
Bethesda, MD 20892
Network and Infrastructure Support for Development of Interdisciplinary Aging Research (R24)
Program Announcement (PA) Number: PA-12-064
"The purpose of this FOA is to provide network and infrastructure support to foster development of novel interdisciplinary research approaches on important topics in aging research. This FOA will use the NIH Resource-Related Research Project (R24) mechanism to facilitate research networks that will advance specific scientific goals through activities such as meetings, conferences, small scale pilots, short term training opportunities, and visiting scholar programs, and dissemination activities to encourage growth and development in these interdisciplinary areas."
National Science Foundation funding grant "General & Age-Related Disabilities Engineering (GARDE)"
"The General & Age Related Disabilities Engineering (GARDE) program supports research that will lead to the development of new technologies, devices, or software for persons with disabilities. Research may be supported that is directed to the characterization, restoration, and/or substitution of human functional ability or cognition, or to the interaction of persons with disabilities and their environment. Areas of particular recent interest are disability-related research in neuroscience/neuroengineering and rehabilitation robotics. Emphasis is placed on significant advancement of fundamental engineering and scientific knowledge and not on incremental improvements. Proposals should advance discovery or innovation beyond the frontiers of current knowledge in disability-related research. Applicants are encouraged to contact the Program Director Ted Conway at email@example.com, or call (703) 292-7091, prior to submitting a proposal."
The New Investigator Awards in Alzheimer's Disease
"Funded by The Rosalinde and Arthur Gilbert Foundation and The Diane and Guilford Glazer Foundation, the major goal of this partnership program is to support important research in areas in which more scientific investigation is needed to improve the prevention, diagnosis, and treatment of Alzheimer's disease. The program will also serve to encourage junior investigators in the United States and Israel to pursue research and academic careers in the neurosciences, and Alzheimer's disease in particular. Projects in basic and translational research related to Alzheimer's disease (AD) that are clinically relevant, will be considered. Projects that focus on healthy brain aging are also considered. For one of the awards, priority may be given to an investigator with a research interest related to healthy brain aging. Areas of research could for example include learning and memory, nutrition, exercise, cardiovascular risk factors, as they relate to the brain and the aging process. The applicant must be an independent investigator with assigned independent space as assigned by the departmental chair or equivalent official, and must be within the first ten years of receiving a doctoral degree by July 1, 2011. Exceptions to the ten year rule may be requested for unusual circumstances by emailing an NIH-style bio-sketch to AFAR at firstname.lastname@example.org .The proposed research must be conducted at any type of not-for-profit setting in the United States or Israel."
The Translational Research Institute on Pain in Later Life (TRIPLL) is an NIA funded Edward R. Roybal center with a focus on persistent pain due to both cancer and non-cancer related causes. TRIPLL is a collaboration between investigators at Weill Cornell Medical College, Cornell-Ithaca, Columbia University's Mailman School of Public Health, Hospital for Special Surgery, Memorial Sloan Kettering Cancer Center, Visiting Nurse Service of New York and Council of Senior Centers & Service of NYC, Inc.
For more information on TRIPLL please contact Marcus Warmington at email@example.com.