Science          Education          Outreach
March 2016
In This Issue
Upcoming Events

April 4-6
 Bethesda Marriott
Bethesda, MD

April 11-12

Biocides USA (rescheduled)
Washington DC

IIVS Study Director, Dr., Emilia Costin, to present on the global acceptance of in vitro methods.

April 12-14


Johns Hopkins University
Baltimore, MD

In the News

Our Contributors
British American Tobacco
Johnson & Johnson
L Brands
Mary Kay
The Procter & Gamble Company
SC Johnson & Son
IIVS at SOT 2016: March 13-17,
New Orleans, LA

Are you going to SOT 2016?

If so, be sure to stop by our booth (#1412) to talk with IIVS study directors, Kim Norman, Allison Hilberer, and Holger Behrsing. Our client development representative, Lindsay Krawiec, and Erin Hill, IIVS President will also be on-hand. 

We are pleased to have several posters at the meeting (see below), and will be holding an ancillary meeting on Monday, March 14, 5-6 pm on our collaborative efforts in respiratory toxicology. 
We look forward to an exciting meeting and to seeing you there!
IIVS Poster Presentations at SOT 2016
Tues, 3/15, 1:15-4:30 pm

3D Cell and Organ-on-a-Chip Models
Abstract #
Poster #
Effect of Acclimation Conditions on 3D Human
In Vitro ALI Airway Models: Exposure-Induced Inflammatory Response and Sampling Location - Specific Results

 Alternative Models for Ocular and Skin Toxicity
Abstract #
Poster #
Combining In Silico and In Vitro Methods to Improve the Accuracy of Skin Sensitization Predictions for Chemicals
Correlation of Two In Vitro EpiOcular Test Methods and Consumer Eye Irritation Data for Cleaning Products

Thurs., 3/17, 9:30 am - 12:45 pm
Late-Breaking Poster Session 6
Abstract #
Poster #
Evaluation of New Solvents for the Use in the Multi-Dose Reconstructed
Human Epidermis (RhE) Phototoxicity Assay

Join Us for Our Ancillary Meeting at SOT
"Tobacco Regulatory Science: Collaborative Efforts in Respiratory Toxicology"
Enjoy refreshments and learn about our growing respiratory toxicology program at our ancillary meeting during SOT on 
March 14, 5-6 pm.
 We will provide updates on our conference series and laboratory services. The meeting will be in the Hilton New Orleans (Fountain Room).

IIVS Awarded Grant to Develop
Non-Animal Testing Strategy for Respiratory Sensitization
IIVS has received a grant from the Research Institute for Fragrance Materials (RIFM) to develop non-animal test methods for the evaluation of fragrance materials for potential respiratory irritation and sensitization.
The grant was secured in collaboration with Liverpool John Moores University and the Physicians Committee for Responsible Medicine. The proposal, "The use of a novel non-animal platform to characterize respiratory effects of fragrance materials" combines computational approaches as well as in chemico techniques, and includes a testing plan in harmony with concepts for the OECD Adverse Outcome Pathway program.

Register for Our Upcoming Workshop: In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products
There is still time to register for our
2.5-day workshop
April 4-6 that promotes the use of 
in vitro models in testing and assessing the potential toxicity of pulmonary toxicants.

Presenters from industry, government, academia, and non-profits will explore topics such as:

* Tobacco smoke and e-cigarette aerosols
* Air-liquid interface - in vitro exposure systems
* Dosimetry approaches for particles and vapors
* In vitro dosimetry determinations
* Exposure microenvironment/physiology of cells

For more information and to view a preliminary agenda click here

IIVS Trains Scientists on In Vitro Methods at Annual Training Course
More than a dozen scientists from industry, government, and academia attended our annual training course, "Practical Methods for
In Vitro Toxicology", Jan. 11-14, 2016 at our Gaithersburg, MD facility.
During the multi-day program, participants learned key laboratory techniques for conducting in vitro assays and how to interpret the data. The program featured a combination of lectures and hands-on activities with our highly trained biologists and Study Directors.
The program kicked off with an overview of in vitro toxicology followed by lectures on GLPs in the laboratory, global acceptance of animal alternatives, and 21st century toxicology. Days 2-4 featured a combination of lectures and hands-on laboratory experience on a variety of in vitro assays, including the Bovine Corneal Opacity and Permeability Assay (BCOP), 3T3 Phototoxicity Assay, the use of 3D tissue constructs for Skin Irritation Testing and more.
We would like to thank our invited speaker, Dr. Martin Stephens of the Johns Hopkins' Center for the Alternatives to Animal Testing (CAAT). We would also like to thank the generous support provided by MatTek Corporation and In Vitro International Inc.

Funding Opportunity: ARDF Soliciting
Research Proposals
Deadline: May 2, 2016
The Alternatives Research & Development Foundation, which funds and promotes alternatives to the use of laboratory animals in research, testing and education, is currently soliciting research proposals.

  • Potential to significantly reduce or replace laboratory animals
  • Scientific merit and feasibility
Preference for proposals that:
  • Utilize in silico and in vitro methods with human cells or tissues
  • Use pathway-based approaches as exemplified by the 2007 National Academy of Sciences report, Toxicity Testing in the Twenty-first Century: A Vision and A Strategy
  • Submitted by individuals from US institutions
IIVS coordinates the review process for grant proposals, working with its wide network of scientists, along with ARDF's President, Sue Leary, to create opportunities for scientists who have compelling research initiatives in the area of non-animal research.

Maximum award per project: $40,000 
  • Deadline:  May 2, 2016
  • Notification of recipients:  July 18, 2016
  • Download 2016 Guidelines and Application at 
If you have any questions about the grant, send an e-mail to

IIVS: Proud Member of Animal Charities of America
We are pleased to be an approved charity of the Animal Charities of America for 2016. Contributions are critical to our mission to increase the use and acceptance of non-animal test methods worldwide. 
Learn more about our Outreach activities and how to get involved.  

View IIVS Webinars and Videos on Our YouTube Page
Visit our new YouTube page to view a collection of webinars and videos highlighting our assays, including: