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Day 1
 
8:00 - 9:00     Registration and Continental Breakfast
 
9:00 - 9:15     Introduction and Overview of Meeting Plan,
                      Erin Hill, IIVS and Martha Moore, ENVIRON
 
9:15 - 9:45     TBA,  Hans Rosenfeldt, FDA-Center for Tobacco Products
 
9:45 - 10:00    Animals Don't Smoke: Ending Tobacco Experiments on Animals,
                       Joseph Manuppello, PETA International Science Consortium, Ltd.
 
10:00 - 10:15   In Vitro Toxicity Testing of Tobacco Products: A Manufacturer's
                        Perspective, Betsy Bombick,  R.J. Reynolds Tobacco
 
 10:15 - 10:45  Considerations for Test Method Validation, Rodger Curren, IIVS
 
10:45 - 11:15   Break
 
11:15 - 11:30  Adverse Outcome Pathways: A Framework for Organizing
                       Mechanistic Information to Improve Chemical Assessment,
                       Kristie Sullivan, Physicians Committee for Responsible Medicine
 
11:30 - 12:00   Etiology of COPD and In Vitro Models, Holger Behrsing, IIVS
 
12:00 - 12:30   Overview of the Clinical Aspects of COPD, Sanjay Sethi, University at
                        Buffalo
 
12:30 - 2:00    Lunch followed by Poster Viewing
 
 
Inflammation and Oxidative Stress
 
2:00 -2:30      The Impact of Tobacco Smoke on Lung Inflammation and           
                      Pro-resolving Pathways in Humans, Animal Models and In Vitro Models,
                      Richard Phipps, University of Rochester
 
2:30 - 3:00     Importance of Genotype for In Vitro Models of Chronic Bronchitis,
                      Yohannes Tesfaigzi, Lovelace Respiratory Research Institute

3:00 - 3:30     Break
 
3:30 - 4:00     Overview of Non-Animal Approaches to Address the Relative COPD
                      Risks of Inhaled Nicotine-Delivering Products. SHerwin Yan, Lorillard
 
4:00 - 4:30     Discussion: Inflammation and Oxidative Stress
 
4:30 - 6:00     Poster Reception
 
6:00               Dinner for All Attendees
 
 

Day 2
 
 
8:30 - 9:00      Continental Breakfast
  
Ciliary Dysfunction and Ion Transport
 
9:00 - 9:30      Measuring Airway Surface Liquid Volume and Mucus Transport
                       by Fluorescence Microscope, Robert Tarran, University of North
                       Carolina
 
9:30 - 10:00     Ciliary Dysfunction in Chronic Obstructive Pulmonary Disease,
                        Samuel Constant, Epithelix
 
10:00 - 10:30   The Impact of Tobacco Smoke Exposure on Ciliary Dysfunction and
                        Ion Transport, Gary Phillips, British American Tobacco
 
10:30 - 11:00   Discussion: Ciliary Dysfunction and Ion Transport
 
11:00 - 11:30   Break
 
Goblet Cell Hyperplasia and Mucus Production
 
11:30 - 12:00   Effect of Azithromycin on Goblet Cell Hyperplasia induced in an
                        In Vitro Human Airway Model by Cigarette Smoke, Simulated
                        Viral  Exposure or TH3 Cytokines, Patrick Hayden, MatTek Corp.
 
 12:00 - 12:30   Measurement of Mucin Secretion for Potential Evaluation of the
                         Toxicity of Tobacco Products n Human Air-Liquid-Interface
                         Airway Models, Xuefei Cao, FDA National Center for
                         Toxicological Research
 
12:30 - 2:00     Lunch Followed by Poster Viewing
 
2:00 - 2:30       Combining Systems biology, Computational Approach and Human
                        Organotypic In Vitro Model Exposed to Whole Cigarette Smoke: An
                        Example of 21st Century Toxicology Assessment, Carole Mathis, Philip
                        Morris International R&D
 
2:30 - 3:00       Discussion: Goblet Cell Hyperplasia and Mucus Production
 
3:00 - 3:15       Breakout Group Objectives, Hans Raabe, IIVS
                        
3:15 - 5:15      Moderated Breakout Group Discussions (breaks as appropriate)
 
5:15 - 6:45      Poster Reception
 
Dinner (on your own)
 


Day 3
 
8:00 - 8:30      Continental Breakfast  
 
Parenchymal/Bronchial Tissue Destruction and Remodeling
 
8:30 - 9:00      Detection of Inflammation and Parenchymal Damage Using Precision-cut
                       Lung Slices, Holger Behrsing, IIVS
 
9:00 - 9:30      Use of Precision-cut  Lung Slices to Test Physiological and
                       Pathophysiological Lung Response, Armin Braun, Fraunhofer
                       Institute for Toxicology and Experimental  Medicine
 
9:30 - 10:00     Discussion: Parenchymal/Bronchial Tissue Destruction and Remodeling
 
10:00 - 10:30    Break
 
10:30 - 12:00    Continuation of Moderated Breakout Groups from Day 2 (breaks as
                         appropriate)
 
12:00 - 1:00      Lunch
 
1:00 -2:00        Breakout Group Discussions Wrap-Up (as needed)
 
2:00 - 4:00       Reports from Breakout Groups and Discussion-Workshop Conclusions
 
 
 
Funding for this conference was made possible, in part, by the Food and Drug Administration through grant 1 R13 FD 005299 - 01. Views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Humans Services; nor does any mention of the trade names, commercial practices or organization imply endorsement by the United States Government.