Request for Poster Abstracts


 

The IIVS Workshop, "Assessment of In Vitro COPD Models for Tobacco Regulatory Science", is accepting abstract submissions for the scheduled poster sessions. It is requested the submitted abstracts focus on the workshop topic and be limited to the following subject matters:

 

  • In vitro or ex vivo pulmonary models as applied to detection and quantitation of biomarkers with known involvement in COPD etiology. While presentations using human models is desired, any in vitro/ex vivo data that may translate to a human tissue-based model will be considered.
  • The development, validation, and application of in vitro/ex vivo models as tools for regulatory agency decision-making regarding product safety. While an emphasis on tobacco product regulations and pulmonary models is desirable, the presentation of any in vitro/ex vivo models used successfully in (or on a development path for) a regulatory setting will be considered.


 

Abstracts should be limited to 250 words (12 point, Times New Roman font), including the title, authors, and author affiliations. Author affiliations should be denoted with numerical superscript assignments. Please note that submitted abstracts not conforming to the requirements may be returned to the submitting author for revision. Abstracts may also be reformatted at IIVS's discretion to match the workshop formatting, as necessary. While IIVS encourages the submission of abstracts that address the topics listed, it is acknowledged that a limited number of poster spaces may result in not all abstracts being accepted. Poster abstracts submitted first and those most closely fitting the subject matters (and overarching theme of the workshop) will be given preference for acceptance. 


 

 
Abstracts should be emailed to Dr. Holger Behrsing at [email protected]

 

 

Sample Abstract:

 

Testing Framework for Prediction of Ocular Irritation Using the Bovine Corneal Opacity and Permeability (BCOP) Assay and Chorioallantoic Membrane Vascular Assay (CAMVA)

 

A. Carrao1, K. Norman2, D. Cameron1, G. Mun2, N. Wilt2, A. Hilberer2, J. Avalos1 and F. Simion1.1Kao USA Inc., Cincinnati, OH and 2 Institute for In Vitro Sciences Inc., Gaithersburg, MD.

 

In vitro ocular irritation assays, such as the Chorioallantoic Membrane Vascular Assay (CAMVA) and Bovine Corneal Opacity and Permeability (BCOP) test, are routinely used by personal care products companies because they are rapid and economical to conduct, do not require the use of live animals, and provide reliable predictive data. Previous research using an extensive CAMVA and BCOP database at Kao USA Inc. has shown that ocular irritation potential for new hair shampoos, ethanol-based hair stylers, skin cleansers, and skin lotions can be reliably predicted using a decision tree that systematically compares the ingredient composition, particularly ethanol and surfactant content, of the new formulation to previously tested formulations. Because the studies comprising this original database were conducted at a single contract laboratory, a follow-up study using a second contract laboratory was conducted to demonstrate inter-laboratory reliability of the CAMVA/BCOP data-derived decision tree for prediction of ocular irritation potential. Thirty-five personal care products were tested using the CAMVA and/or BCOP assays. The ethanol and surfactant content of each test material was evaluated, and the results of the assays were compared to the decision tree-based predictions of ocular irritation potential. Our data confirmed the ocular irritation predictions made using the decision tree model for 33 of 37 test samples (89% correlation rate) and verified the inter-laboratory reliability of the CAMVA and BCOP assays when conducted using appropriate controls. Our results also strengthened the ocular irritation decision tree model by confirming that deodorants are consistently predicted not to be ocular irritants based on composition.