1. Soil depletion. Even if you're eating piles of organic fruits and vegetables, odds are it's being grown in soil that's been over-farmed, which lowers mineral content. Therefore, you need supplementation to bridge the gap. Not to mention, the genetic modification of crops is affecting our food supply in ways we don't even fully understand but simply cannot be beneficial to the human body.
2. Old food. Unless you buy totally local, foods are often shipped over weeks -- and even months -- to get to your grocery shelf = more nutritional depletion. 
3. Stress. And the increased alcohol, caffeine and sugar consumption that goes along with it raids your body's store of B vitamins as well as Vits C, E and A. Studies show supplementation helps. 
4. Meal skipping. What busy New Yorker doesn't skip breakfast on a regular basis or subsists on almonds until dinner? This results in nutrient deficiencies that can be aided by a multivitamin.
5. Digestion issues. Ninety percent of my practice has some kind of digestion problem. We're not absorbing the vitamins, minerals and other nutrients that our food is supposed to provide. That's why it's important to supplement (or come in to see me to get your gut in better shape). 

What: A study out of UC Irvine showed that the herb Rhodiola rosea extended the life of fruit flies by 24%. This is important because researchers have not, until now, been able to find a substance that extends life expectancy equal to the way calorie restriction does. 

Recommendation: Rhodiola has long been one of my favorite herbs for quelling anxiety, mild depression and fatigue. Try 100 mg/day to start benefitting from its longevity-producing properties. 

What: A study out of California showed that green tea extract (ECGC) equivalent to five to ten cups of green tea a day significantly lowered LDL (the bad cholesterol). 

Recommendation: Do we need another reason to love green tea? It also has been shown to decrease blood pressure and increase insulin sensitivity. Drink up.