Human studies using invasive technology to record or modulate neural circuits require extensive planning and expense. As a result, these studies are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a matter sufficient to address high-impact neuroscience questions with appropriate power. Furthermore, these small scale projects rarely identify or retain additional sources of data beyond their primary endpoints, which could be of high value to the wider scientific community. With this FOA, the NIH seeks to address these fundamental barriers by supporting planning efforts and exploratory research studies investigating high-impact questions in human neuroscience and disorders of the human nervous system. Projects should develop multidisciplinary teams to maximize opportunities to conduct neuroscience research arising from invasive surgical procedures that provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans. Integrated teams should consist of clinicians, scientists, device engineers, mathematicians, statisticians, data scientists, regulatory specialists and/or ethics specialists.

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Questions about this announcement or proposal submission may be directed to Jennifer Corby