Upcoming Events
 Boston Single Cell Network Meeting
Dana-Farber Cancer Institute Dana 1620 (Smith Family Room)
Tuesday, Dec. 2
4:00-5:30 PM

The HSCI Technology Series

was developed to best serve researchers in their day-to-day experimental work. Experts in up-and-coming protocols present and answer your questions. Please join us at future events:

HSCI Technology Series: All-optical Electrophysiology
Sherman Fairchild 261
Thursday, Nov. 13
12:00-1:00 PM

HSCI Technology Series: CRISPR
Sherman Fairchild 268
Thursday, Dec. 4
12:00-1:00 PM
HSCI iPS Core Training
December 4-5, 2014
Bauer Building Room B01
Human Pluripotent Stem Cell Culture: Feeder versus Feeder-free
 $425 for HSCI members. Spaces limited - Register early
Elliot Chaikof, MD, PhD, elected to Institute of Medicine

Xi He, PhD, and Matthew Meyerson, MD, PhD, to receive American Cancer Society Research Professor Awards
People News
Frank Slack, PhD, director of the newly formed Institute for RNA Medicine at Beth Israel joins HSCI as a Principal Faculty member; Lev Silberstein, MD, PhD, co-organizer of the Boston Single Cell Network, joins as an Affiliated Faculty member

Iain Drummond, PhD, is named an HSCI Principal Faculty member and co-leader of the HSCI Kidney Program, he joins Benjamin Humphreys, MD, PhD
Job Postings
Billions of Beta Cells
Doug Melton, PhD, publishes his protocol for generating "bucket-loads" of human insulin-producing cells

After 15 years of trial-and-error work, Melton shows in Cell how stem cell-derived beta cells made in his lab respond appropriately to glucose challenges when transplanted into mice. Non-human primate animal trials are currently underway at the University of Illinois. "It was gratifying to know that we could do something that we always thought was possible," said Melton, "but many people felt it wouldn't work. If we had shown this was not possible, then I would have had to give up on this whole approach. Now I'm really energized." Read the press release. The work was praised by media around the world: Washington Post, CBS News, WBUR, National Geographic  

Barcoding Stem Cells
Fernando Camargo, PhD, and team use new technology to track the origin of blood cells; many more applications
A 7-year-project to develop a barcoding and tracking system for tissue stem cells has revealed that the billions of blood cells that we produce each day may not be made not by blood stem cells, but rather blood progenitor cells. The researchers hypothesize that blood comes from stable populations of different long-lived progenitor cells that are responsible for giving rise to specific blood cell types, while blood stem cells likely act as essential reserves. Read the paper in Nature or the press release.
Resource: 10 Big Questions to Dissect Science Papers 
From M. William Lensch, PhD, of HSCRB
The list is adapted by a lecture Lensch gave at the Novartis Institutes for Biomedical Research Summer Scholars Program. Question 1: What is the central point the authors are trying to prove? Read carefully to determine whether the authors actually get there or fall short and/or over-interpret results.
Research updates