September 2013 HSCI Community Newsletter
The Harvard Stem Cell Matrix
Upcoming Events
Blood Program Meeting
Sept. 23, 3:30PM-5:00PM

Diabetes Think Tank
Oct. 16, 9:00AM-5:00PM

Cancer Program Symposium
Nov. 8, 8:00AM-12:00PM
Announcements
Brigham and Women's Hospital Begins BRI Leaders in Regenerative Medicine Seminar Series
Amy Wagers, PhD, Robert Langer, PhD, and David Scadden, MD, will speak over coming months.
Jobs
Media Mentions

9/9/13
New York Times
George Daley, MD, PhD, comments on the rise of stem cell tourism. Daley also spoke to The Scientist, about new research on using in vivo iPS cells in mice.

9/7/13
 Science Today Podcast
Episode features a USCF-Harvard collaboration with Amy Wagers, PhD, on how leukemia cells remodel the bone marrow niche.
The Self-Repairing Adrenal Gland
David Breault, MD, PhD, finds evidence of natural lineage conversion

 

In 2006, Shinya Yamanaka, MD, PhD, discovered a way to reprogram mature skin cells back to a stem cell state so they can be converted into any cell type a scientist is interested in studying. His research raised the tantalizing question of whether similar reprogramming occurs in nature.  

 

In fact, it does, discovered HSCI Principal Faculty member David Breault, MD, PhD, who has just shown that the adrenal gland uses cellular reprogramming (called lineage conversion) for both its daily maintenance and regeneration following injury. Continue reading

 

Read the paper in Developmental Cell.
Making Blood Vessel Stem Cells
Guillermo García-Cardeña, PhD, mimics blood flow to spur differentiation

 

In a scientific first, HSCI scientists have successfully grown the cells that line the blood vessels--called vascular endothelial cells--from human induced pluripotent stem cells (iPSCs), revealing new details about how these cells function.  

 

Using a unique approach, the researchers induced the differentiation of specific cell types by generating mechanical forces on the surface of the iPSC-derived endothelium mimicking the flow of blood. For example, cells that felt a stronger "flow" became artery cells, while those that felt a weaker "flow" became vein cells. Continue reading

 

Read the paper in Stem Cell Reports.
Member News
  • Lee Rubin, PhD, and Kevin Eggan, PhD, collaborate with Evotec AG to advance ALS research. The agreement marks the third collaboration between Evotec and HSCI scientists. 
  • Khalid Shah, PhD, has a new book on "Stem Cell Therapeutics for Cancer," which covers stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. 
  • Tatsuya Kobayashi, MD, from the MGH Endocrine Unit and David Milan, MD, from the MGH Cardiovascular Research Center, join HSCI as Affiliated Faculty members.