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January 2014 Newsletter 
In This Issue
Visit our Facebook Page
Influenza A virus pH1N1 Update
Mobile App Updates
Website Updates
Recent Blog Posts
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Updated Articles This Month
 
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An Interview with Dr  Fred Plapp, Author of www.ClinLabNavigator.com
An Interview with Dr Fred Plapp, Author of www.ClinLabNavigator.com

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by Fred V. Plapp MD PhD by BookSurge Publishing
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Influenza A virus pH1N1 Update

 

A swine-origin influenza A virus was been identified as the cause of outbreaks of the febrile respiratory infection that has spread throughout the world since 2009. It has reemerged as the dominant cause of influenza during the 2013 -2014. This virus has genes from human, swine and avian influenza A viruses and has been called novel influenza A (H1N1).

 

Age-specific attack rates for 2009 novel influenza A (H1N1) virus infection cases are higher in younger persons and lower in older individuals, compared with seasonal influenza infections. Older persons, as a group, might have preexisting immunity to the 2009 H1N1 virus. One small study indicated that approximately one third of adults aged >60 years had cross-reactive antibody to 2009 influenza A (H1N1) virus detected, compared with none detected among children. Another factor might be higher contact rates among youger adults.

 

A number of different laboratory diagnostic tests can be used for detecting the presence of influenza viruses in respiratory These tests differ in their sensitivity and specificity in detecting influenza viruses as well as their ability to distinguish between different influenza virus types (A versus B) and influenza A subtypes (e.g. novel H1N1 versus seasonal H1N1 versus seasonal H3N2 viruses).

 

Rapid influenza diagnostic tests are antigen detection tests that detect influenza viral nucleoprotein antigen. The major advantage of rapid tests is that they can provide results within 30 minutes or less.  Rapid antigen testing detects and differentiates both influenza A and B. Compared to PCR, the rapid antigen's detection rate for this season's predominant strain has been 60-80%. Higher sensitivity is obtained with specimens collected from children than from adults.The CDC has concluded that a positive rapid influenza result can be useful in making treatment decisions, however, a negative result does not rule out infection.

 

PCR testing for influenza viruses is also available. In addition to influenza B, the Cepheid Flu A/B PCR detects influenza A H1 and H3 subtypes and differentiates 2009 H1N1. Sensitivity averages 90% with specificity near 100%. Nasopharygeal or nasal swabs submitted in viral transport media or nasal washes are the only acceptable specimen types for flu A/B PCR.

 
In addition to influenza, the Biofire respiratory PCR panel detects coronavirus, human metapneumovirus, rhinovirus, parainfluenza, RSV, adenovirus, Bordetella pertussis, Mycoplasma pneumoniae, and Chlamydophila pneumoniae. The predominant influenza subtype detected by PCR testing this season is influenza A 2009 H1. Coronavirus, rhinovirus, metapneumovirus, RSV, and Mycoplasma are also detected frequently. The respiratory PCR panel can be performed on bronchoscopy specimens in addition to nasal swabs or washes.
 

 

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Mobile
New versions of our apps are UNDER REVIEW with Apple.  We expect them to be available in the next 1-2 weeks.


Phase II for ALL Mobile Apps:
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News
ClinLab Navigator
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Recent Changes:
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Coming Soon:
  • Pathology job board - we are almost done with the job board.  Still in the works. 
 
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