The MCIRCC Catalyst | June 2015

University of Michigan Center for Integrative Research in Critical Care

News for MCIRCC Members, Insiders and the U-M Critical Care Community

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From the Directors
2014/15 Impact Report

Greetings Members & Stakeholders,

As the fiscal year 2014/15 comes to a close and 2015/16 begins, we enter a new year with a great deal to be proud of and even more to look forward to. It's only fitting that we share MCIRCC's achievements and future goals with the individuals that made this journey possible, and that's you--our dedicated members and key stakeholders.

Looking back, this journey started just two years ago with one aspirational vision: To transform critical care medicine for improved patient care and outcomes by accelerating science and moving it from bench to bedside.

Driven by our mission and guided by our organizing principles, MCIRCC has made tremendous headway thanks in part to the MCIRCC Catalyst--the framework that unites and integrates our unique combination of assets including operational structures, membership programs and technology systems to execute MCIRCC's vision in a scalable design.


To bring together world-class expertise and create partnerships throughout U-M and with external partners to develop and deploy critical care solutions that are precise, predictive, proactive, and personalized for real world impact.



To prioritize research aimed at rapid translation from bench to bedside:

  • Push research beyond the idea stage for real world impact
  • Create groundbreaking new technologies, products and services
  • Help researchers and industry partners commercialize innovations
  • MCIRCC Catalyst
    click image for larger view

    The result is the creation of a new, innovative business model at U-M for the academic research enterprise that provides end-to-end management of the research pipeline. MCIRCC's performance over the past year has proven this model to be efficient, cost effective and nimble.

    On the data front, every discussion and future-state prediction about transforming healthcare involves data analytics. Big data, or what we at MCIRCC like to call the "right data," paired with advanced technology is an important facet of our brand and integral to our future success and sustainability. To that end, MCIRCC is poised to create even greater value for our members and the larger institution with its Critical Care Data Mart that utilizes a holistic hospital-to-home care model.

    And so, the momentum we have achieved thus far is a direct result of aligning our strategic goals with the four target opportunities outlined below--opportunities that matter most to our members, internal stakeholders, and industry partners while considering market influences.

    By all accounts and any measure, this was a groundbreaking year for MCIRCC and we are well positioned for major impact potential for the foreseeable future.

    On behalf of the entire MCIRCC Catalyst Team, thank you for your continued support and confidence, because together, we will change the face of critical care medicine


    Kevin Ward, MD, Executive Director

    Shuichi Takayama, PhD, Associate Director

    Janene Centurione, Managing Director


    Because of the fast pace and complexity of critical care, many of the most important problems can only be answered through multidisciplinary research teams. At the same time, funding opportunities are increasing for large-scale, team-driven research that tackles complex problems like critical care with transformative solutions.

    Exploit this target-rich environment using the MCIRCC integrated team science model to create and accelerate high-impact research outputs within the critical care space. Develop strategies that significantly lower the barriers to integrated team science.


    "The major barriers to the development of large, team science initiatives are: 1) No central convening body. We tend to think of teams as focused in one school yet to bring partners together from an array of schools and colleges requires someone to harness that talent together. There are also grants administrative barriers to facilitating this with concerns about indirect cost flow, etc. 2) There is insufficient incentive to bring teams together. There are too few mechanisms to support bringing teams together with "start up funds" and even more importantly to arm these teams with project management support that is so critical with percent effort supported faculty who do not dedicate their entire time/effort to the project. 3) Academic credit for participating as a 'team member' needs to be adequately recognized via the promotion and tenure process."


    Thomas P. Shanley, MD

    Medical School Associate Dean, Clinical and Translational Research

    Director, Michigan Institute for Clinical & Health Research (MICHR)

    Janette Ferrantino Professor of Pediatrics

    Professor, Pediatrics and Communicable Diseases


    • Early awareness of big opportunities
    • Rapid alert and mobilization of integrated science teams
    • Leverage foundational research communities for strategic advantage
    • Accelerate "best in class" proposals with dedicated project management
    • Support high-risk research with new funding sources
    2014/15 OUTPUT SUMMARY
    • Launched Proposal Development Unit: dedicated to team science proposal strategies
    • Cultivated an Integrated Membership Base: 120 world-class scientists, clinicians and engineers
    • Formed Foundational Research Communities: sepsis, traumatic brain injury (TBI), hemodynamic instability and cardiac arrest
    • Launched the Virtual Institute: intranet to enhance member communication and collaboration
    • Allied Strategic Industry Partners: poised to support research efforts
    • Unified Patient Test Beds: 10 critical care units including the EC3
    • Created Research Funding Continuity: funding plans that link MTRAC Kickstart, MTRAC Life Sciences, COE Coulter, MCIRCC Grand Challenge and major gifts
    • Established a Proposal Pipeline: $1.3M awarded, $2M submitted, $10-12M in development (NIH, NSF, DOD)
    2015/16 FUTURE GOALS
    • Integrated Membership Base: retain existing members and recruit new members
    • Proposal Pipeline:
      • $4M NIH-NIBIB Quantum Program proposal submitted January 2016 targeting sepsis
      • $1M continuation support for sepsis and TBI Grand Challenge teams
      • $10-12M via NIH, NSF, DOD
    • Virtual Institute 2.0: improve sharing of funding opportunities and enhance member connections within research communities
    • Research Communities: scale up foundational research communities and develop new communities
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    U-M provides the ideal environment to assume an elite position among academic institutions in bringing university-led critical care innovations to market.

    The MCIRCC Catalyst has developed a strong commercialization-focused infrastructure to amplify innovation and prioritize research aimed at rapid translation from bench to bedside.

    • Team science rooted in clinical and market relevance
    • Alignment with FDA regulatory considerations and commercialization pathways
    • Early integration strategies with industry, entrepreneurs and donors
    • Emphasize platform technologies for impact across the spectrum of care
    2014/15 OUTPUT SUMMARY
    • Recruited Expert Advisors: commercialization coaches, industry mentors and strong relationship with the Office of Tech Transfer
    • Active Portfolio Management: executed 18 patents, 24 disclosures, 32 NDAs; in discussions with industry to license 10 technologies
    • Developed Fast Contracting System: executed 4 Master Alliance Agreements with major industry partners
    • Engaged Strategic Industry Partnerships: gifts and sponsored research driving license deals and royalty stream

    "MCIRCC has been extremely helpful in introducing us to individuals who have been helpful in addressing patenting and licensing issues for our idea. We also have a very good priority score on an SBIR application we submitted with a potential licensee. MCIRCC funding was critical for us to obtain preliminary data for this application."


    Jonathan Rubin, MD, PhD

    Professor of Radiology

    "MCIRCC has certainly provided greater access to tech transfer expertise and strong connections with end [medical] users than typically available through an individual department. The ability to move technology into human subjects testing quite rapidly and smoothly is especially exciting."



    Kenn Oldham, PhD

    Assistant Professor, Mechanical Engineering

    2015/16 FUTURE GOALS
    • Strategic Industry Partnerships: active industry collaboration and sponsored research based on Master Alliance Agreements
    • Explore New Initiatives:
      • Connected Health in Critical Care: sensors and devices
      • New Vital Signs: sleep, new waveforms, biomarkers and genomics
      • Hospital Bed of the Future: integration of vibration and temperature
    • Active Portfolio Management: continuation of MAAs, patents, disclosures, NDAs and license agreements
    MCIRCC Portfolio Management Stats
    "MCIRCC is the model for how commercial-academic partnerships must work--it is highly action oriented and the team solved the economic and operational complexities that usually plague academic partnerships with industry."

    Matt Patterson, MD

    President, AirStrip

    The fast pace and complexity of critical care makes it ripe for transformative change using advanced technology solutions. In addition, forthcoming healthcare reform and market shifts will further stress the patient care delivery system, requiring health systems to respond and adapt via innovative and disruptive solutions to stay relevant and ahead of the competition. UMHS is in a position to own the marketplace for the creation and testing of such solutions that elevate patient care at a reduced cost.

    Bridge the gap between clinical experts, research masterminds, industry partners and technological advances to transform critical care delivery using data in motion and cognitive computing to improve patient outcomes at reduced costs.

    • Deploy big data analytic platform to elevate value of analytics portfolio via agile research, development and testing
    • Blend clinical expertise with predictive analytics and cognitive computing to develop clinical decision support tools
    • Utilize advanced analytics to deliver personalized and evidence-based medicine in UMHS test beds
    • Advance patient-centric hospital-to-home care models
    2014/15 OUTPUT SUMMARY
    • Commenced Big Data Platform Build: multiphase installation and optimization of IBM big data technologies and systems infrastructure
    • Developed Critical Care Data Mart: aggregating integrated data from inside and outside the hospital including structured, unstructured, financial, waveform and quantified health data
    • Conceived Critical Care Solutions: Project AHI (analytic for hemodynamic instability) is the first predictive analytic test case using the big data platform with real-time streaming capabilities within UMHS test beds for early diagnosis and intervention


    "The vision that MCIRCC has for transforming the delivery of critical care not only at the University of Michigan Health System, but across the world, is inspiring. We really wanted to be a part of helping to enable bringing that vision to reality."


    Mark Aretha

    Big Data & Analytics Sales Specialist, IBM


    2015/16 FUTURE GOALS
    • Translational Research & Big Data Platform: leverage with new grant applications in the critical care space
    • Critical Care Data Mart: support "insight as a service" for internal and external customers
    • Critical Care Solutions: Project AHI (analytic for hemodynamic instability) starts research on streaming data (summer 2015); continue to test and refine through 2016

    "MCIRCC has designed and developed an extraordinary technological infrastructure to tackle big-data analytic challenges head on. This platform will enable researchers, practitioners and management to constantly, iteratively and quickly translate novel ideas from the research bench into lifesaving solutions at the patient bedside."


    Ashwin Belle, PhD

    Analytics Architect, MCIRCC

    View MCIRCC's Big Data Analytic Platform
    click image for larger view

    The fast pace and complexity of critical care makes it ripe for transformative change using advanced technology solutions. These disruptive solutions appeal to a unique, untapped pool of sophisticated benefactors willing to contribute their entrepreneurial expertise, passion and financial support to influence science and discovery for high-impact, real-world solutions.


    Cultivate new funding sources for high-risk/high-reward discovery work and translational research by offering government agencies, donors and strategic industry leaders a seat at the table for sustained partnerships.

    • Offer mechanisms that allow benefactors to provide iterative and positive feedback to drive exploration, impact and output in critical care
    • Measure success based on products delivered to market that improve patient outcomes at reduced costs
    • Develop marketing communications that engage the "right" donors and industry partners for financial and resource support of key initiatives
    2014/15 OUTPUT SUMMARY
    • Delivered Marketing Communications that capture the essence of the critical care story and engages the intellect of benefactors. Rapid response to Massey TBI-ask played a major role in securing $7M gift and is driving stewardship for next large ask.
    • Created Accelerant Fund/Grand Challenge Program to effectively deploy revenue streams:
      • Distributed $300K in funding to 6 sepsis teams
      • Sepsis story gets U-M attention at Celebrate Invention
      • Leads to potential license of bundled sepsis products to industry partners


    "We work with a large number of academic research institutions and I can safely say that we have never encountered a center that unites all the stakeholders in the community so effectively.  The power and uniqueness of MCIRCC, as we see it, is their ability to focus the energy and passion of the medical, engineering, academic, government, donor, and industrial communities to a single purpose."


    Pete Tchoryk

    CEO, SpringMatter

    2015/16 FUTURE GOALS
    • Marketing Communications: launch MCIRCC 2.0, the next wave of messaging and story-telling tools across all communication channels
    • Accelerant Fund/Grand Challenge Program: Massey TBI Grand Challenge, October 2015; $750K for potential distribution to integrated project teams
    • Federal Funding: active strategic partnerships with DoD
    • Industry Sponsored Research: continue to cultivate strategic partnerships with industry for co-development opportunities

    Download the MCIRCC Sepsis Portfolio Brochure

    Download the Massey TBI Info Sheet

    The U-M Center for Integrative Research in Critical Care (MCIRCC) is one of the world's first comprehensive research enterprises devoted to transforming critical care medicine by accelerating science and moving it from bench to bedside. To do this, MCIRCC brings together integrative teams comprised of world-class U-M scientists, clinicians, and engineers with industry partners and funding sources to develop and deploy cutting-edge solutions that elevate the care, outcomes, and quality of life of critically ill and injured patients and their families.