The MCIRCC Catalyst | June 2015

University of Michigan Center for Integrative Research in Critical Care

News for MCIRCC Members, Insiders and the U-M Critical Care Community

www.micircc.org

mcirccinfo@umich.edu

734.647.4751

FROM THE DIRECTORS

STATE OF THE CENTER:

2014/15 Impact Report

Greetings Members & Stakeholders,

As the fiscal year 2014/15 comes to a close and 2015/16 begins, we enter a new year with a great deal to be proud of and even more to look forward to. It's only fitting that we share MCIRCC's achievements and future goals with the individuals that made this journey possible, and that's you--our dedicated members and key stakeholders.

Looking back, this journey started just two years ago with one aspirational vision: To transform critical care medicine for improved patient care and outcomes by accelerating science and moving it from bench to bedside.

Driven by our mission and guided by our organizing principles, MCIRCC has made tremendous headway thanks in part to the MCIRCC Catalyst--the framework that unites and integrates our unique combination of assets including operational structures, membership programs and technology systems to execute MCIRCC's vision in a scalable design.

MISSION STATEMENT

To bring together world-class expertise and create partnerships throughout U-M and with external partners to develop and deploy critical care solutions that are precise, predictive, proactive, and personalized for real world impact.

ORGANIZING PRINCIPLES

To prioritize research aimed at rapid translation from bench to bedside:

Push research beyond the idea stage for real world impact

Create groundbreaking new technologies, products and services

Help researchers and industry partners commercialize innovations

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The result is the creation of a new, innovative business model at U-M for the academic research enterprise that provides end-to-end management of the research pipeline. MCIRCC's performance over the past year has proven this model to be efficient, cost effective and nimble.

On the data front, every discussion and future-state prediction about transforming healthcare involves data analytics. Big data, or what we at MCIRCC like to call the "right data," paired with advanced technology is an important facet of our brand and integral to our future success and sustainability. To that end, MCIRCC is poised to create even greater value for our members and the larger institution with its Critical Care Data Mart that utilizes a holistic hospital-to-home care model.

And so, the momentum we have achieved thus far is a direct result of aligning our strategic goals with the four target opportunities outlined below--opportunities that matter most to our members, internal stakeholders, and industry partners while considering market influences.

By all accounts and any measure, this was a groundbreaking year for MCIRCC and we are well positioned for major impact potential for the foreseeable future.

On behalf of the entire MCIRCC Catalyst Team, thank you for your continued support and confidence, because together, we will change the face of critical care medicine.

Sincerely,

Kevin Ward, MD, Executive Director

Shuichi Takayama, PhD, Associate Director

Janene Centurione, Managing Director

TARGET OPPORTUNITY #1

Because of the fast pace and complexity of critical care, many of the most important problems can only be answered through multidisciplinary research teams. At the same time, funding opportunities are increasing for large-scale, team-driven research that tackles complex problems like critical care with transformative solutions.

THE MCIRCC SOLUTION

Exploit this target-rich environment using the MCIRCC integrated team science model to create and accelerate high-impact research outputs within the critical care space. Develop strategies that significantly lower the barriers to integrated team science.

"The major barriers to the development of large, team science initiatives are: 1) No central convening body. We tend to think of teams as focused in one school yet to bring partners together from an array of schools and colleges requires someone to harness that talent together. There are also grants administrative barriers to facilitating this with concerns about indirect cost flow, etc. 2) There is insufficient incentive to bring teams together. There are too few mechanisms to support bringing teams together with "start up funds" and even more importantly to arm these teams with project management support that is so critical with percent effort supported faculty who do not dedicate their entire time/effort to the project. 3) Academic credit for participating as a 'team member' needs to be adequately recognized via the promotion and tenure process."

Thomas P. Shanley, MD

Medical School Associate Dean, Clinical and Translational Research

Director, Michigan Institute for Clinical & Health Research (MICHR)

Janette Ferrantino Professor of Pediatrics

Professor, Pediatrics and Communicable Diseases

STRATEGIC APPROACH

Early awareness of big opportunities
Rapid alert and mobilization of integrated science teams
Leverage foundational research communities for strategic advantage
Accelerate "best in class" proposals with dedicated project management
Support high-risk research with new funding sources

2014/15 OUTPUT SUMMARY

Launched Proposal Development Unit: dedicated to team science proposal strategies
Cultivated an Integrated Membership Base: 120 world-class scientists, clinicians and engineers
Formed Foundational Research Communities: sepsis, traumatic brain injury (TBI), hemodynamic instability and cardiac arrest
Launched the Virtual Institute: intranet to enhance member communication and collaboration
Allied Strategic Industry Partners: poised to support research efforts
Unified Patient Test Beds: 10 critical care units including the EC3
Created Research Funding Continuity: funding plans that link MTRAC Kickstart, MTRAC Life Sciences, COE Coulter, MCIRCC Grand Challenge and major gifts
Established a Proposal Pipeline: $1.3M awarded, $2M submitted, $10-12M in development (NIH, NSF, DOD)

2015/16 FUTURE GOALS

Integrated Membership Base: retain existing members and recruit new members
Proposal Pipeline:

$4M NIH-NIBIB Quantum Program proposal submitted January 2016 targeting sepsis
$1M continuation support for sepsis and TBI Grand Challenge teams
$10-12M via NIH, NSF, DOD

Virtual Institute 2.0: improve sharing of funding opportunities and enhance member connections within research communities
Research Communities: scale up foundational research communities and develop new communities

TARGET OPPORTUNITY #2

U-M provides the ideal environment to assume an elite position among academic institutions in bringing university-led critical care innovations to market.

THE MCIRCC SOLUTION

The MCIRCC Catalyst has developed a strong commercialization-focused infrastructure to amplify innovation and prioritize research aimed at rapid translation from bench to bedside.

STRATEGIC APPROACH

Team science rooted in clinical and market relevance
Alignment with FDA regulatory considerations and commercialization pathways
Early integration strategies with industry, entrepreneurs and donors
Emphasize platform technologies for impact across the spectrum of care

2014/15 OUTPUT SUMMARY

Recruited Expert Advisors: commercialization coaches, industry mentors and strong relationship with the Office of Tech Transfer
Active Portfolio Management: executed 18 patents, 24 disclosures, 32 NDAs; in discussions with industry to license 10 technologies
Developed Fast Contracting System: executed 4 Master Alliance Agreements with major industry partners
Engaged Strategic Industry Partnerships: gifts and sponsored research driving license deals and royalty stream

"MCIRCC has been extremely helpful in introducing us to individuals who have been helpful in addressing patenting and licensing issues for our idea. We also have a very good priority score on an SBIR application we submitted with a potential licensee. MCIRCC funding was critical for us to obtain preliminary data for this application."

Jonathan Rubin, MD, PhD

Professor of Radiology

"MCIRCC has certainly provided greater access to tech transfer expertise and strong connections with end [medical] users than typically available through an individual department. The ability to move technology into human subjects testing quite rapidly and smoothly is especially exciting."

Kenn Oldham, PhD

Assistant Professor, Mechanical Engineering

2015/16 FUTURE GOALS

Strategic Industry Partnerships: active industry collaboration and sponsored research based on Master Alliance Agreements
Explore New Initiatives:

Connected Health in Critical Care: sensors and devices
New Vital Signs: sleep, new waveforms, biomarkers and genomics
Hospital Bed of the Future: integration of vibration and temperature

Active Portfolio Management: continuation of MAAs, patents, disclosures, NDAs and license agreements

"MCIRCC is the model for how commercial-academic partnerships must work--it is highly action oriented and the team solved the economic and operational complexities that usually plague academic partnerships with industry."

Matt Patterson, MD

President, AirStrip

TARGET OPPORTUNITY #3

The fast pace and complexity of critical care makes it ripe for transformative change using advanced technology solutions. In addition, forthcoming healthcare reform and market shifts will further stress the patient care delivery system, requiring health systems to respond and adapt via innovative and disruptive solutions to stay relevant and ahead of the competition. UMHS is in a position to own the marketplace for the creation and testing of such solutions that elevate patient care at a reduced cost.

THE MCIRCC SOLUTION

Bridge the gap between clinical experts, research masterminds, industry partners and technological advances to transform critical care delivery using data in motion and cognitive computing to improve patient outcomes at reduced costs.

STRATEGIC APPROACH

Deploy big data analytic platform to elevate value of analytics portfolio via agile research, development and testing
Blend clinical expertise with predictive analytics and cognitive computing to develop clinical decision support tools
Utilize advanced analytics to deliver personalized and evidence-based medicine in UMHS test beds
Advance patient-centric hospital-to-home care models

2014/15 OUTPUT SUMMARY

Commenced Big Data Platform Build: multiphase installation and optimization of IBM big data technologies and systems infrastructure
Developed Critical Care Data Mart: aggregating integrated data from inside and outside the hospital including structured, unstructured, financial, waveform and quantified health data
Conceived Critical Care Solutions: Project AHI (analytic for hemodynamic instability) is the first predictive analytic test case using the big data platform with real-time streaming capabilities within UMHS test beds for early diagnosis and intervention

"The vision that MCIRCC has for transforming the delivery of critical care not only at the University of Michigan Health System, but across the world, is inspiring. We really wanted to be a part of helping to enable bringing that vision to reality."

Mark Aretha

Big Data & Analytics Sales Specialist, IBM

2015/16 FUTURE GOALS

Translational Research & Big Data Platform: leverage with new grant applications in the critical care space
Critical Care Data Mart: support "insight as a service" for internal and external customers
Critical Care Solutions: Project AHI (analytic for hemodynamic instability) starts research on streaming data (summer 2015); continue to test and refine through 2016

"MCIRCC has designed and developed an extraordinary technological infrastructure to tackle big-data analytic challenges head on. This platform will enable researchers, practitioners and management to constantly, iteratively and quickly translate novel ideas from the research bench into lifesaving solutions at the patient bedside."

Ashwin Belle, PhD

Analytics Architect, MCIRCC

View MCIRCC's Big Data Analytic Platform

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TARGET OPPORTUNITY #4

The fast pace and complexity of critical care makes it ripe for transformative change using advanced technology solutions. These disruptive solutions appeal to a unique, untapped pool of sophisticated benefactors willing to contribute their entrepreneurial expertise, passion and financial support to influence science and discovery for high-impact, real-world solutions.

THE MCIRCC SOLUTION

Cultivate new funding sources for high-risk/high-reward discovery work and translational research by offering government agencies, donors and strategic industry leaders a seat at the table for sustained partnerships.

STRATEGIC APPROACH

Offer mechanisms that allow benefactors to provide iterative and positive feedback to drive exploration, impact and output in critical care
Measure success based on products delivered to market that improve patient outcomes at reduced costs
Develop marketing communications that engage the "right" donors and industry partners for financial and resource support of key initiatives

2014/15 OUTPUT SUMMARY

Delivered Marketing Communications that capture the essence of the critical care story and engages the intellect of benefactors. Rapid response to Massey TBI-ask played a major role in securing $7M gift and is driving stewardship for next large ask.
Created Accelerant Fund/Grand Challenge Program to effectively deploy revenue streams:

Distributed $300K in funding to 6 sepsis teams
Sepsis story gets U-M attention at Celebrate Invention
Leads to potential license of bundled sepsis products to industry partners

"We work with a large number of academic research institutions and I can safely say that we have never encountered a center that unites all the stakeholders in the community so effectively. The power and uniqueness of MCIRCC, as we see it, is their ability to focus the energy and passion of the medical, engineering, academic, government, donor, and industrial communities to a single purpose."

Pete Tchoryk

CEO, SpringMatter

2015/16 FUTURE GOALS

Marketing Communications: launch MCIRCC 2.0, the next wave of messaging and story-telling tools across all communication channels
Accelerant Fund/Grand Challenge Program: Massey TBI Grand Challenge, October 2015; $750K for potential distribution to integrated project teams
Federal Funding: active strategic partnerships with DoD
Industry Sponsored Research: continue to cultivate strategic partnerships with industry for co-development opportunities

ABOUT MCIRCC

The U-M Center for Integrative Research in Critical Care (MCIRCC) is one of the world's first comprehensive research enterprises devoted to transforming critical care medicine by accelerating science and moving it from bench to bedside. To do this, MCIRCC brings together integrative teams comprised of world-class U-M scientists, clinicians, and engineers with industry partners and funding sources to develop and deploy cutting-edge solutions that elevate the care, outcomes, and quality of life of critically ill and injured patients and their families.