June 2014
CONNECT [ events > meetings > networking ]
Innovation Underground Moves Above Ground:
First annual Show & Tell event spotlights member innovations
As you know, what sets MCIRCC apart from other programs at U-M is our drive to push research and innovations to the bedside; to implement interdisciplinary projects for real world results. And what better way to bring together ideas, theories, and research from scientists, engineers, clinicians, entrepreneurs, and others than during a friendly gathering of the minds?

Welcome to MCIRCC's Innovation Show & Tell -- the opportunity for all our members to gather and share ideas, stories, experiences, developments, and challenges. And by this measure, it was a wonderful success!

More than 40 people attended the first annual event with nine tabletop project demonstrations showcasing a myriad of concepts, prototypes and models including:

  • Hands-on Google Glass presentation
  • Piezo sensor for continuous, non-invasive cardiovascular monitoring 
  • Continuous monitoring and early detection of hemodynamic decompensation 
  • Passive monitoring system for heart failure patients
  • Brain cooling device for stroke patients 
  • Electrical muscle stimulation (EMS) to prevent disuse atrophy in ICU patients 
  • Microcirculation imaging to assess functional capillary density
  • Non-invasive measurement of tissue oxygen saturation using Resonance Raman spectroscopy 
  • Non-invasive bioimpedance measurements to determine intravascular volume status

This event presented members the opportunity to discover what others are working on, gather feedback from potential end users, and to establish new partnerships with those from other fields. Discussions were lively and full of groundbreaking ideas that could usher in a new wave of critical care solutions.
Members of the U-M Office of Technology Transfer were also on site to talk about how we can bring these projects to fruition. "The Office of Technology Transfer wants to get these ideas out of the lab and into the marketplace," said Mentor-in-Residence Ken Spenser. "We have the resources to make this happen, so we form a natural relationship [with MCIRCC]. Mixers like these help ensure that these innovations are commercially viable, that the verification of salability is completed sooner so that we don't have to go back and re-do the whole project when we hit a glitch."
According to Spenser, one of the most exciting things about the emerging healthcare field is that advances come from all different directions, not just medicine, not just laboratory research. "There are a lot of people coming up with similar ideas from different angles and backgrounds who don't even know each other," he said, "and the Innovation Show & Tell was the perfect opportunity to begin collaborations to create the kinds of advances that no one has thought possible before."
Thanks, again, to all who attended Innovation Show & Tell and presented, chimed in, and learned about the future of critical care. We hope to see you again next year!
[ team science tools ]
Enhanced Member Services Coming Soon:
Because success begets success
To cultivate and maximize your success and loyalty, MCIRCC must be successful in delivering the right tools and resources in a format that fits your needs.

As such, you will soon see MCIRCC roll out a series of enhanced service options in the upcoming months to enrich member communication, support new funding streams, and facilitate idea sharing and access to all things critical care.

In addition, be on the lookout for a member value survey in the next month to help us determine what benefits and experiences you value most as a MCIRCC member.

Because our goal is to provide you, our membership, the innovation, financial, business and commercialization guidance and resources you need to get your research to the bedside.

INTEGRATE [tech > clinical products > people]
Grand Challenge, Grand Innovations:
Interdisciplinary teams inch closer to $100,000 for innovative sepsis solutions
MCIRCC is taking on the big problems in critical care using interdisciplinary teams to develop innovative solutions that address some of the most daunting complications in critical care delivery. And this year's Critical Care Grand Challenge is no exception. 

Back in January, we invited our members to come up with real world solutions to positively impact sepsis, an incredibly complex public health problem that represents the single largest diagnostic cost in the United States. With more than 1 million cases each year and a mortality rate of up to 40 percent, sepsis poses a unique challenge for the patient, family, clinician and healthcare system.

The Critical Care Grand Challenge will support high-impact proposals from integrated science teams, composed of joint principal investigators from U-M's Medical School and the College of Engineering, at a funding level up to $100,000 per project. 

MCIRCC received 14 proposals, and during the past few months, an external panel of experts -- including ICU physicians, members of the U-M Office of Technology Transfer and Fast Forward Medical Innovation, and industry and venture capital professionals -- has painstakingly narrowed the field to eight projects that offer the most potential for significant clinical impact in the most efficient timeframe. Critical success factors used to evaluate these proposals included:

Where is the project in the development of the idea? Is there a prototype already in the works?

Sepsis-Specific Data
Is there ample evidence to suggest that the idea would positively and immediately affect sepsis diagnosis and treatment? 

Intellectual Property
What intellectual property is involved, and how will it be protected?

Clinical Impact
Does the proposal clearly outline the potential direct effects in the field and by the bedside? 

And now the eight shortlisted project teams have entered the final stretch, working with their assigned mentors and other U-M support groups to prepare a detailed 10-page project plan that will include implementation foundations such as specific milestones and timeframes, informative decisions points, value proposition and customer discovery. The end-goal is to identify real-world challenges and practical uses.

Final project plans are due June 27, followed by project "pitch day" on July 16 where each team will present their plans and potential bedside benefits to an oversight committee for final funding decisions.

We're looking for innovative approaches to the diagnosis and treatment of sepsis, and the Critical Care Grand Challenge pushes these projects past the idea stage to create real world impact. Who will come out ahead? Stay tuned for more information on our awardees and their groundbreaking projects, coming in July!

ACCELERATE [ projects > initiatives ]
MCIRCC Announces First Industry Collaboration Agreement:
Partnering with NovoDynamics to develop next-generation clinical decision support tools
In a move to impact both patient health and the critical care industry, MCIRCC has announced a new partnership with NovoDynamics, Inc. -- a company that develops pattern recognition and predictive analytics solutions -- to advance the efficacy of critical illness and traumatic injury. 

When treating a critically ill or injured patient, physicians and clinicians are confronted with a multitude of time-related variables including, but not limited to, heart rate, blood pressure, intracranial pressure, cerebral blood flow, brain tissue oxygenation, imaging scans, laboratory results, medical history and patient feedback. And yet, as humans we can only determine the relationship between two variables unassisted. Furthermore, all this health data is typically stored and analyzed as separate, unrelated resources.

Combined, these factors can lead to a delay in, or incomplete, diagnosis during the early stages of critical care and traumatic injury which directly impact patient treatment, outcomes and later, quality of life. To combat this information overload and enhance the situational awareness for critical care teams, MCIRCC has entered into a master collaboration agreement with NovoDynamics to accelerate the development and commercialization of the next generation of clinical decision support (CDS) solutions to improve patient outcomes, enhance the clinician experience and reduce healthcare costs.

Under the agreement, MCIRCC and NovoDynamics will develop real-time CDS solutions driven by adaptive learning algorithms operating on large datasets of patient information including medical images, real-time biosensor data, laboratory values, patient histories and treatment outcomes. Ultimately, the development and commercialization of these cutting-edge technologies will provide critical care physicians and clinicians better tools to quickly diagnose traumatic injuries for the implementation of personalized, time-sensitive treatments.

"This collaboration marries the strengths of MCIRCC/U-M's translational research, particularly critical care, predictive analytics, and signal processing, with NovoDynamics' expertise in advanced pattern recognition, image analysis, data mining and product commercialization," said Kevin R. Ward, M.D., executive director of MCIRCC. "We are pleased to join forces with NovoDynamics to aggressively tackle critical care trauma and the burden it poses on the patient, clinician and healthcare system." 

"Trauma is the leading cause of death for Americans between the ages of 1 and 44 and critical care represents a yearly cost to the economy in excess of $260 billion, that's nearly 40 percent of total hospital costs," said David A. Rock, president and chief executive officer at NovoDynamics.

This partnership is just the first of many collaborative ventures with industry who share MCIRCC's patient-focused mission and vision for delivering evidence-based "personalized" medicine across the spectrum of critical care.

Though there is currently no dollar value associated with this agreement and details will be worked out as the partnership evolves, if successful, the results will be invaluable to critical care support and patient quality of life. The idea is to go from "bench to bedside" and deliver real world solutions as quickly and efficiently as possible.

For more information contact MCIRCC Managing Director Janene Centurione at jrcentu@umich.edu.

IMPACT [ announcements > funding > pubs ]
It Takes a Team:
MCIRCC hires technology expert to lead clinical decision support initiative
MCIRCC is pleased to announce that Mark Salamango has joined the Catalyst Team as a Senior Product Manager.

In this role, Mark will lead MCIRCC's efforts to build the Clinical Decision Support (CDS) platform driven by big data analytics and adaptive learning algorithms. This critical care CDS platform will support scalable translational research and real time commercial grade product development. In addition, Mark will coach MCIRCC's translational and clinical research teams on development and prototyping of real-world products that have high impact.

Mark comes to MCIRCC with over 20 years of strategy, software and product development, and project management experience with organizations including the University of Michigan Medical School, Pratt and Miller Engineering, Silicon Graphics Inc., and the U.S. Army. He received his M.S. in Computer Science from Lawrence Technological University where he studied software architecture and robotics and his B.S. in Computer Science from the University of Michigan.

Mark was selected as Crain's 40 Under 40 and has presented at TEDxDetroit on robotics. He has been the keynote speaker at several technology conferences and is passionate about using technology to solve problems.

Please join us in welcoming Mark to Team MCIRCC! You can reach Mark at mmango@umich.edu. 
Critical Care Trifecta: 
EC3 project will advance patient care, research and education
Every day, some of the most critically ill and injured patients come through the doors of the University of Michigan Health System's adult emergency department (ED). Once stabilized by emergency medicine teams, most of these patients head for an operating room or directly upstairs to one of U-M's six specialized adult intensive care units (ICUs).

Come spring 2015, these super-critical emergency patients will get an even higher level of care from the moment of arrival through the first crucial hours, all within the ED's new Emergency Critical Care Center, or EC3. Though the $7 million project has been in the works for some time, the U-M Board of Regents gave the official go ahead last month.

Among the first of its kind in the U.S., the 7,800-square-foot EC3 will give teams of doctors, nurses, respiratory therapists, pharmacists and others room for patients' initial diagnosis and stabilization, and an ICU-level environment for initial care. The EC3 may mean some patients can get through an initial health crisis without needing an ICU bed at all. That's an important goal given the high demand for U-M ICU care and the ever-growing number of patients coming to U-M hospitals.

"We are seeing a growing number of complex critically ill and injured emergency patients who require time-sensitive diagnosis and treatment in order to achieve the best outcomes," said Robert Neumar, M.D., Ph.D., MCIRCC member and chair of the U-M Medical School's Department of Emergency Medicine. "EC3 will give us an environment where we can deliver the right care at the right time, beginning as soon as the patient arrives in the ED." 

Designed with research in mind, the EC3 will make it easier for teams to test new diagnostics, devices, monitoring equipment and treatment strategies. By ensuring closer connections between emergency and intensive care staff, the EC3 will help ensure that patients who qualify for a study will be identified and enrolled, before hours slip by or they receive care that might make them ineligible.

MCIRCC Member Kyle Gunnerson, M.D., the U-M emergency physician and critical care specialist who will lead the EC3, emphasized the importance of this relationship. "We have a window of a few minutes to a few hours to diagnose and treat these patients, so having cutting-edge ICU infrastructure with critical care expertise in the ED will preserve precious time and perhaps shorten their overall hospital or ICU stay," he said. "As we seek to push this type of care forward through innovative approaches and technologies, the EC3 will act as a test-bed of new ideas."

MCIRCC anticipates many of these new ideas will come to the EC3 through our members and industry partnerships. "I can't express how valuable this is to our membership - the ability to test new critical care solutions from the point of patient entry to the ED is priceless," said Kevin R. Ward, M.D., executive director of MCIRCC. "In the end, the ultimate benefactors are the critically injured patients who may now experience a shorter overall hospital stay with improved outcomes."

The new facility will also serve as the training ground for a new breed of emergency critical care physicians.

For more information about the EC3, please visit the UMHS website for the full announcement and project renderings.
Don't forget your MCIRCC affiliation!
If you are speaking with the media about your work in critical care research or are working with the U-M News Service or U-M Health System Public Relations on a health care related press release, article, or other news item, please mention your MCIRCC affiliation!
SAVE THE DATE: Registration details coming soon!
October 10, 2014
Innovation Underground
5:00pm - 7:00pm
Location TBD

October 23, 2014
MCIRCC Member Report
4:00pm - 7:00pm
NCRC Building 10 Auditorium "State of the Union" presentation followed by member cocktail mixer

November 20, 2014
Innovation Underground
5:00pm - 7:00pm
Location TBD

January 30, 2015
Innovation Underground
5:00pm - 7:00pm

January 30-31, 2015
Critical Care Grand Challenge
Friday: 1:00pm - 5:00pm
Saturday: 8:00am - 2:00pm
NCRC Building 10, South Atrium 
July 9, 2014
Catch the Wave of the Digital Medicine Revolution
5:00pm - 7:00pm
NCRC Building 10, Research Auditorium
Free Attendance - Register Now

July 30, 2014
The Secrets of Non-Disclosure Agreements
5:30pm - 6:30pm
NCRC, Building 10, South Atrium Free Attendance - Register Now

August 20, 2014
Bridging the Valley of Death: Funding to Help You Cross
5:30pm - 6:30pm
NCRC, Building 10, South Atrium Free Attendance - Register Now

August 27, 2014
11:00 a.m. - 2:00 p.m.
Circle Drive in front of Med Sci I
During the annual UMHS Ice Cream Social