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Tip of the Month

Power Outages and ECIS Data Acquisition  

As we move through the summer season with occasional thunderstorms, the likelihood of a power
outage in the laboratory can be very real.  Should this happen while you are taking ECIS data, it is reassuring to know that the data acquired by your instrument are continually being stored on the PC's hard drive.  Thus, none of the data acquired before the outage are lost.  In addition, if the data are being gathered by a laptop that remains powered by its battery, when the power outage is over, the system will automatically resume taking data with a gap in the display over the time of the outage.


If your system is being controlled with a computer that has no battery backup, then with loss of power all data acquisition will be halted and it will be necessary to restart the system. If power is regained in a reasonable time, it is possible to rescue the experiment by following the instructions below: 

  • Reboot the ECIS software
  • Do the normal Setup procedure
  • Start a new time course file with exactly the same parameters used before the outage - the same acquisition program (for example MFT), the same frequencies, the same naming of the array (for example 8W10E+) and the identical selection of wells. 
  • Continue with the experiment and when all is complete finish data acquisition 

Now you have two files - one before and one after the power outage.   In the data analysis program these datasets can now be appended. 


Open the two files and display the first file; click on the Edit tab and then select <Append Data Sets> and choose the second file.  The display now shows the two files combined including the time gap between them when no data were collected.


In the example below, cells were inoculated in an 8W10E+ array at time zero and then approximately 1.25 hours into the run there was a loss of power for about 45 minutes.  When power returned, a new run was started and the two files were joined with the append software.  Notice that during the outage there are no data points, and the gap has been filled with a straight line for each well.




This new combined data set may now be explored with the analysis software and, if desired, stored as a .csv file.


Note:  this ability to append files is also handy should one inadvertently terminate data acquisition and want to continue an experiment with little interruption in the time course measurement.


ECIS Application Webinar Series


ECIS application webinars review the topics listed below in 20 to 30 minute, web-based, interactive seminars presented by Applied BioPhysics president and co-founder, Dr. Charles Keese.

All webinars are held at 11:00 am EST. To register for a webinar, please go to: and scroll to the webinar date of interest.  


Cell Attachment and Spreading Measurements -  July 21, 2015


Signal Transduction Assays - September 8, 2015

Toxicology with ECIS - September 22, 2015

ECIS Theory - October 6, 2015

Latest ECIS Software   

The latest version of the software is v1.2.201 available from: 

Software Tip:


All ECIS arrays now come with a printed serial number and barcode for easy identification. When setting up an experiment this information can be used to specify the array type and track the array used in the comments. To do this automatically, select the menu item from Acquire | Array Serial # | Use Array Serial #. Then click Setup and enter the serial number when prompted. To manually enter or change the serial number select Enter Array Serial # from the same menu. The letter prefix specifies the array type, and the number is 6 or 7 digits.

A barcode scanner can also be used to scan the code and automatically populate the dialog box. One shortcut is that when using 2 arrays, you can scan the A and B codes as one entry and the software will interpret them as separate items.

An appropriate barcode scanner is available from Applied BioPhysics.


Tradeshows & Events 

Vascular Biology 2015
October 18 - 22, 2015
Hyannis, MA


ASCB Annual Meeting
Dec 12  - 16, 2015
San Diego, CA

5th Annual SLAS International Conference & Exhibition

January 23 - 27, 2016

San Diego, CA


SOT Annual Meeting

March 13 - 17, 2016

New Orleans, LA


Experimental Biology

April 2 - 6, 2016

San Diego, CA


AACR Annual Meeting

April 17 - 20, 2016

New Orleans, LA


ATS 2016

May 13 - 18, 2016

San Francisco, CA

Recent Publications 



Adderley, Shaquria P., Curtis Lawrence, Eyong Madonia, Joseph O. Olubadewo, and Jerome W. Breslin. "Histamine Activates p38 MAP Kinase and Alters Local Lamellipodia Dynamics, Reducing Endothelial Barrier Integrity and Eliciting Central Movement of Actin Fibers." American Journal of Physiology - Cell Physiology 309, no. 1 (July 1, 2015): C51-59. doi:10.1152/ajpcell.00096.2015.

Adderley, Shaquria P., Xun E. Zhang, and Jerome W. Breslin. "Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction." Microcirculation 22, no. 4 (May 2015): 237-48. doi:10.1111/micc.12189.

Balasubramaniam, Sona Lakshme, Anilkumar Gopalakrishnapillai, Vimal Gangadharan, Randall L. Duncan, and Sonali P. Barwe. "Sodium-Calcium Exchanger 1 Regulates Epithelial Cell Migration via Calcium-Dependent Extracellular Signal-Regulated Kinase Signaling." Journal of Biological Chemistry 290, no. 20 (May 15, 2015): 12463-73. doi:10.1074/jbc.M114.629519.

Banerjee, Santanu, Jana Ninkovic, Jingjing Meng, Umakant Sharma, Jing Ma, Richard Charboneau, and Sabita Roy. "Morphine Compromises Bronchial Epithelial TLR2/IL17R Signaling Crosstalk, Necessary for Lung IL17 Homeostasis." Scientific Reports 5 (June 15, 2015): 11384. doi:10.1038/srep11384.

Banki, Eszter, Danuta Sosnowska, Zsuzsanna Tucsek, Tripti Gautam, Peter Toth, Stefano Tarantini, Andrea Tamas, et al. "Age-Related Decline of Autocrine Pituitary Adenylate Cyclase-Activating Polypeptide Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 70, no. 6 (June 2015): 665-74. doi:10.1093/gerona/glu116.

Barabutis, Nektarios, Christiana Dimitropoulou, Charalampos Birmpas, Atul Joshi, Gagan Thangjam, and John D Catravas. "p53 Protects against LPS-Induced Lung Endothelial Barrier Dysfunction." American Journal of Physiology - Lung Cellular and Molecular Physiology, February 20, 2015, ajplung.00334.2014. doi:10.1152/ajplung.00334.2014.

Bellotti, Mariela I, Fabián E Giana, and Fabián J Bonetto. "Impedance Spectroscopy Applied to the Fast Wounding Dynamics of an Electrical Wound-Healing Assay in Mammalian Cells." Measurement Science and Technology 26, no. 8 (August 1, 2015): 085701. doi:10.1088/0957-0233/26/8/085701.

Birukova, Anna A., Fanyong Meng, Yufeng Tian, Angelo Meliton, Nicolene Sarich, Lawrence A. Quilliam, and Konstantin G. Birukov. "Prostacyclin Post-Treatment Improves LPS-Induced Acute Lung Injury and Endothelial Barrier Recovery via Rap1." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852, no. 5 (May 2015): 778-91. doi:10.1016/j.bbadis.2014.12.016.

Bondu, Virginie, Ron Schrader, Mary Gawinowicz, Paul McGuire, Daniel Lawrence, Brian Hjelle, and Tione Buranda. "Elevated Cytokines, Thrombin and PAI-1 in Severe HCPS Patients Due to Sin Nombre Virus." Viruses 7, no. 2 (February 10, 2015): 559-89. doi:10.3390/v7020559.

Breslin, Jerome W., Xun E. Zhang, Rebecca A. Worthylake, and Flavia M. Souza-Smith. "Involvement of Local Lamellipodia in Endothelial Barrier Function." PLOS ONE 10, no. 2 (February 6, 2015): e0117970. doi:10.1371/journal.pone.0117970.

Breus, Vladimir V, Anna Pietuch, Marco Tarantola, Thomas Basché, and Andreas Janshoff. "The Effect of Surface Charge on Nonspecific Uptake and Cytotoxicity of CdSe/ZnS Core/shell Quantum Dots." Beilstein Journal of Nanotechnology 6 (January 26, 2015): 281-92. doi:10.3762/bjnano.6.26.

Broux, B., M. R. Mizee, M. Vanheusden, S. van der Pol, J. van Horssen, B. Van Wijmeersch, V. Somers, H. E. de Vries, P. Stinissen, and N. Hellings. "IL-15 Amplifies the Pathogenic Properties of CD4+CD28- T Cells in Multiple Sclerosis." The Journal of Immunology 194, no. 5 (March 1, 2015): 2099-2109. doi:10.4049/jimmunol.1401547.

Bussche, Leen, Rebecca M Harman, Bethany A Syracuse, Eric L Plante, Yen-Chun Lu, Theresa M Curtis, Minglin Ma, and Gerlinde R Van de Walle. "Microencapsulated Equine Mesenchymal Stromal Cells Promote Cutaneous Wound Healing in Vitro." Stem Cell Research & Therapy 6, no. 1 (December 2015): 66. doi:10.1186/s13287-015-0037-x.

Cavet, Megan E., Thomas R. Vollmer, Karen L. Harrington, Karl VanDerMeid, and Mary E. Richardson. "Regulation of Endothelin-1-Induced Trabecular Meshwork Cell Contractility by Latanoprostene Bunod." Investigative Opthalmology & Visual Science 56, no. 6 (June 24, 2015): 4108. doi:10.1167/iovs.14-16015.

Chichger, H., H. Duong, J. Braza, and E. O. Harrington. "p18, a Novel Adaptor Protein, Regulates Pulmonary Endothelial Barrier Function via Enhanced Endocytic Recycling of VE-Cadherin." The FASEB Journal 29, no. 3 (March 1, 2015): 868-81. doi:10.1096/fj.14-257212.

Chignalia, Andreia Z., Stephen M. Vogel, Albert B. Reynolds, Dolly Mehta, Randal O. Dull, Richard D. Minshall, Asrar B. Malik, and Yuru Liu. "p120-Catenin Expressed in Alveolar Type II Cells Is Essential for the Regulation of Lung Innate Immune Response." The American Journal of Pathology 185, no. 5 (May 2015): 1251-63. doi:10.1016/j.ajpath.2015.01.022.

Clark, Paul R., Richard K. Kim, Jordan S. Pober, and Martin S. Kluger. "Tumor Necrosis Factor Disrupts Claudin-5 Endothelial Tight Junction Barriers in Two Distinct NF-κB-Dependent Phases." PLOS ONE 10, no. 3 (March 27, 2015): e0120075. doi:10.1371/journal.pone.0120075.

Das, Lopamudra, Soumen Das, and Jyotirmoy Chatterjee. "Electrical Bioimpedance Analysis: A New Method in Cervical Cancer Screening." Journal of Medical Engineering 2015 (2015): 1-5. doi:10.1155/2015/636075.

Dhawan, S., I. H. Hiemstra, C. Verseijden, F. W. Hilbers, A. A. te Velde, L. E. M. Willemsen, J. Stap, J. M. den Haan, and W. J. de Jonge. "Cholinergic Receptor Activation on Epithelia Protects against Cytokine-Induced Barrier Dysfunction." Acta Physiologica 213, no. 4 (April 2015): 846-59. doi:10.1111/apha.12469.

Dong, Fengyun, Hu Tian, Suhua Yan, Liqun Li, Xiaofeng Dong, Fuhai Wang, Jie Li, et al. "Dihydroartemisinin Inhibits Endothelial Cell Proliferation through the Suppression of the ERK Signaling Pathway." International Journal of Molecular Medicine, March 16, 2015. doi:10.3892/ijmm.2015.2140.

Du, Linna, Fengyun Dong, Ling Guo, Yinglong Hou, Fan Yi, Ju Liu, and Dongmei Xu. "Interleukin-1β Increases Permeability and Upregulates the Expression of Vascular Endothelial-cadherin in Human Renal Glomerular Endothelial Cells." Molecular Medicine Reports, January 9, 2015. doi:10.3892/mmr.2015.3172.

Eldawud, Reem, Alixandra Wagner, Chenbo Dong, Yon Rojansakul, and Cerasela Zoica Dinu. "Electronic Platform for Real-Time Multi-Parametric Analysis of Cellular Behavior Post-Exposure to Single-Walled Carbon Nanotubes." Biosensors and Bioelectronics 71 (September 2015): 269-77. doi:10.1016/j.bios.2015.04.044.

Fairaq, Arwa, Anna Goc, Sandeep Artham, Harika Sabbineni, and Payaningal R. Somanath. "TNFα Induces Inflammatory Stress Response in Microvascular Endothelial Cells via Akt- and P38 MAP Kinase-Mediated Thrombospondin-1 Expression." Molecular and Cellular Biochemistry 406, no. 1-2 (August 2015): 227-36. doi:10.1007/s11010-015-2440-0.

Flemming, S., N. Burkard, M. Renschler, F. Vielmuth, M. Meir, M. A. Schick, C. Wunder, et al. "Soluble VE-Cadherin Is Involved in Endothelial Barrier Breakdown in Systemic Inflammation and Sepsis." Cardiovascular Research 107, no. 1 (July 1, 2015): 32-44. doi:10.1093/cvr/cvv144.

Gamal, W., S. Borooah, S. Smith, I. Underwood, V. Srsen, S. Chandran, P.O. Bagnaninchi, and B. Dhillon. "Real-Time Quantitative Monitoring of hiPSC-Based Model of Macular Degeneration on Electric Cell-Substrate Impedance Sensing Microelectrodes." Biosensors and Bioelectronics 71 (September 2015): 445-55. doi:10.1016/j.bios.2015.04.079.

Ghosh, Chandra C., Aditi Mukherjee, Sascha David, Katelyn E. Milam, Jon T. Hunter, and Samir M. Parikh. "Angiopoietin-1 Requires Oxidant Signaling through p47phox to Promote Endothelial Barrier Defense." PLOS ONE 10, no. 3 (March 11, 2015): e0119577. doi:10.1371/journal.pone.0119577.

Gibson, C. C., W. Zhu, C. T. Davis, J. A. Bowman-Kirigin, A. C. Chan, J. Ling, A. E. Walker, et al. "Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation." Circulation 131, no. 3 (January 20, 2015): 289-99. doi:10.1161/CIRCULATIONAHA.114.010403.

Glasbey, James, Andrew Sanders, David Bosanquet, Fiona Ruge, Keith Harding, and Wen Jiang. "Expression of Hepatocyte Growth Factor-Like Protein in Human Wound Tissue and Its Biological Functionality in Human Keratinocytes." Biomedicines 3, no. 1 (February 4, 2015): 110-23. doi:10.3390/biomedicines3010110.

Gong, Haixia, Jalees Rehman, Haiyang Tang, Kishore Wary, Manish Mittal, Pallavi Chatturvedi, Youyang Zhao, Yulia A. Komorova, Stephen M. Vogel, and Asrar B. Malik. "HIF2α Signaling Inhibits Adherens Junctional Disruption in Acute Lung Injury." Journal of Clinical Investigation 125, no. 2 (February 2, 2015): 652-64. doi:10.1172/JCI77701.

Good, Robert B., Adrian J. Gilbane, Sarah L. Trinder, Christopher P. Denton, Gerry Coghlan, David J. Abraham, and Alan M. Holmes. "Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension." The American Journal of Pathology 185, no. 7 (July 2015): 1850-58. oi:10.1016/j.ajpath.2015.03.019.

Hampel, Ulrike, Antje Schröder, Todd Mitchell, Simon Brown, Peta Snikeris, Fabian Garreis, Carolina Kunnen, Mark Willcox, and Friedrich Paulsen. "Serum-Induced Keratinization Processes in an Immortalized Human Meibomian Gland Epithelial Cell Line." PLOS ONE 10, no. 6 (June 4, 2015): e0128096. doi:10.1371/journal.pone.0128096.

Hyun Jo, Dong, Rimi Lee, Jin Hyoung Kim, Hyoung Oh Jun, Tae Geol Lee, and Jeong Hun Kim. "Real-Time Estimation of Paracellular Permeability of Cerebral Endothelial Cells by Capacitance Sensor Array." Scientific Reports 5 (June 5, 2015): 11014. doi:10.1038/srep11014.

Ibrahim, Ahmed S., Sally Elshafey, Hassan Sellak, Khaled A. Hussein, Mohamed El-Sherbiny, Mohammed Abdelsaid, Nasser Rizk, et al. "A Lipidomic Screen of Hyperglycemia-Treated HRECs Links 12/15-Lipoxygenase to Microvascular Dysfunction during Diabetic Retinopathy via NADPH Oxidase." Journal of Lipid Research 56, no. 3 (March 2015): 599-611. doi:10.1194/jlr.M056069.


Jiang, Wen G, Lin Ye, Fiona Ruge, Ping-Hui Sun, Andrew J Sanders, Ki Ji, Jane Lane, Lijian Zhang, Lucy Satherley, and Hoi P Weeks. "Expression of Sonic Hedgehog (SHH) in Human Lung Cancer and the Impact of YangZheng XiaoJi on SHH-Mediated Biological Function of Lung Cancer Cells and Tumor Growth." Anticancer Research 35, no. 3 (2015): 1321-31.


Kheirandish-Gozal, L, M Alonso-Alvarez, J Teran-Santos, D Gozal, and A Khalyfa. "Plasma-Derived Exosomes Alter Endothelial Tight Junction In Obese Children With Obstructive Sleep Apnea: Effect Of Adenotonsillectomy (t&a)." Am J Respir Crit Care Med 191 (2015): A2596.


Kispert, S., J. Marentette, and J. McHowat. "Cigarette Smoke Induces Cell Motility via Platelet-Activating Factor Accumulation in Breast Cancer Cells: A Potential Mechanism for Metastatic Disease." Physiological Reports 3, no. 3 (March 1, 2015): e12318-e12318. doi:10.14814/phy2.12318.


Kondrikov, Dmitry, David Fulton, Zheng Dong, and Yunchao Su. "Heat Shock Protein 70 Prevents Hyperoxia-Induced Disruption of Lung Endothelial Barrier via Caspase-Dependent and AIF-Dependent Pathways." PLOS ONE 10, no. 6 (June 11, 2015): e0129343. doi:10.1371/journal.pone.0129343.


Konig, U., M. Heitzmann, D. Beckmann, J. Hillen, U. Hansen, U. Saunders, C. Hartmann, A. Korb-Pap, and T. Pap. "A6.7 The Junctional Adhesion Molecule JAM-3 Regulates the Motility of Fibroblast-like Synoviocytes." Annals of the Rheumatic Diseases 74, no. Suppl 1 (March 1, 2015): A58-A58. doi:10.1136/annrheumdis-2015-207259.133.


Konya, V, J Maric, K Jandl, P Luschnig, I Aringer, I Lanz, W Platzer, et al. "EP 4 Receptor Prevents Endotoxin-Induced Neutrophil Infiltration into the Airways and Enhances Microvascular Barrier Function." British Journal of Pharmacology, June 2015, n/a - n/a. doi:10.1111/bph.13229.


Kozyulina, P. Y., Y. V. Loskutov, V. K. Kozyreva, A. Rajulapati, R. J. Ice, B. C. Jones, and E. N. Pugacheva. "Prometastatic NEDD9 Regulates Individual Cell Migration via Caveolin-1-Dependent Trafficking of Integrins." Molecular Cancer Research 13, no. 3 (March 1, 2015): 423-38. doi:10.1158/1541-7786.MCR-14-0353.


Kugelmann, Daniela, Jens Waschke, and Mariya Y. Radeva. "Adducin Is Involved in Endothelial Barrier Stabilization." PLOS ONE 10, no. 5 (May 15, 2015): e0126213. doi:10.1371/journal.pone.0126213.


Lai, C. -I., W. -T. Chen, Y. -T. Lai, and C. -M. Lo. "Electrically Assessing the Effect of TGF-β1 on MDA-MB-231 Cells," 188-91, 2015. doi:10.1007/978-3-319-12262-5_52.


Landgraf, Lisa, Ines Müller, Peter Ernst, Miriam Schäfer, Christina Rosman, Isabel Schick, Oskar Köhler, et al. "Comparative Evaluation of the Impact on Endothelial Cells Induced by Different Nanoparticle Structures and Functionalization." Beilstein Journal of Nanotechnology 6 (January 27, 2015): 300-312. doi:10.3762/bjnano.6.28.


Letsiou, E., A. N. Rizzo, S. Sammani, P. Naureckas, J. R. Jacobson, J. G. N. Garcia, and S. M. Dudek. "Differential and Opposing Effects of Imatinib on LPS- and Ventilator-Induced Lung Injury." American Journal of Physiology - Lung Cellular and Molecular Physiology 308, no. 3 (February 1, 2015): L259-69. doi:10.1152/ajplung.00323.2014.


Li, Fu Jun, Ryan N. Duggal, Octavio M. Oliva, Suman Karki, Ranu Surolia, Zheng Wang, R. Douglas Watson, et al. "Heme Oxygenase-1 Protects Corexit 9500A-Induced Respiratory Epithelial Injury across Species." Edited by Ferenc Gallyas. PLOS ONE 10, no. 4 (April 2, 2015): e0122275. doi:10.1371/journal.pone.0122275.


Li, Liqun, Fengyun Dong, Dongmei Xu, Linna Du, Suhua Yan, Hesheng Hu, Corrinne G. Lobe, Fan Yi, Carolyn M. Kapron, and Ju Liu. "Short-Term, Low-Dose Cadmium Exposure Induces Hyperpermeability in Human Renal Glomerular Endothelial Cells." Journal of Applied Toxicology, May 2015, n/a - n/a. doi:10.1002/jat.3168.


Lindsey, Merry L., Fouad A. Zouein, Yuan Tian, Rugmani Padmanabhan Iyer, and Lisandra E. de Castro Brás. "Osteopontin Is Proteolytically Processed by Matrix Metalloproteinase 9 1." Canadian Journal of Physiology and Pharmacology, March 26, 2015, 1-8. doi:10.1139/cjpp-2015-0019.


Liu, Ju, Yan Li, Fengyun Dong, Liqun Li, Takahiro Masuda, Thaddeus D. Allen, and Corrinne G. Lobe. "Trichostatin A Suppresses Lung Adenocarcinoma Development in Grg1 Overexpressing Transgenic Mice." Biochemical and Biophysical Research Communications 463, no. 4 (August 2015): 1230-36. doi:10.1016/j.bbrc.2015.06.090.


Lu, Hongyan, Christophe Poirier, Todd Cook, Dmitry O Traktuev, Stephanie Merfeld-Clauss, Benjamin Lease, Irina Petrache, Keith L March, and Natalia V Bogatcheva. "Conditioned Media from Adipose Stromal Cells Limit Lipopolysaccharide-Induced Lung Injury, Endothelial Hyperpermeability and Apoptosis." Journal of Translational Medicine 13, no. 1 (2015): 67. doi:10.1186/s12967-015-0422-3.


Mao, P., S. Wu, J. Li, W. Fu, W. He, X. Liu, A. S. Slutsky, H. Zhang, and Y. Li. "Human Alveolar Epithelial Type II Cells in Primary Culture." Physiological Reports 3, no. 2 (February 12, 2015): e12288-e12288. doi:10.14814/phy2.12288.


Mayer, Chad L., Caitlin S. L. Parello, Benjamin C. Lee, Kiyoshi Itagaki, Shinichiro Kurosawa, and Deborah J. Stearns-Kurosawa. "Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga Toxins and Host Damage-Associated Molecular Patterns." Frontiers in Immunology 6 (April 7, 2015). doi:10.3389/fimmu.2015.00155.


Men, Wenjin, Tracey A Martin, Fiona Ruge, Ning Zhang, Peng Du, Yong Yang, and Wen G Jiang. "Expression of Claudins in Human Clear Cell Renal Cell Carcinoma." Cancer Genomics-Proteomics 12, no. 1 (2015): 1-8.


Meng, Jingjing, Santanu Banerjee, Dan Li, Gregory M. Sindberg, Fuyuan Wang, Jing Ma, and Sabita Roy. "Opioid Exacerbation of Gram-Positive Sepsis, Induced by Gut Microbial Modulation, Is Rescued by IL-17A Neutralization." Scientific Reports 5 (June 3, 2015): 10918. doi:10.1038/srep10918.


Orr, Sarah K., Romain A. Colas, Jesmond Dalli, Nan Chiang, and Charles N. Serhan. "Proresolving Actions of a New Resolvin D1 Analog Mimetic Qualifies as an Immunoresolvent." American Journal of Physiology - Lung Cellular and Molecular Physiology 308, no. 9 (May 1, 2015): L904-11. doi:10.1152/ajplung.00370.2014.


Persidsky, Yuri, Shongshan Fan, Holly Dykstra, Nancy L. Reichenbach, Slava Rom, and Servio H. Ramirez. "Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium." Journal of Neuroimmune Pharmacology 10, no. 2 (June 2015): 302-8. doi:10.1007/s11481-015-9591-3.


Podjaski, C., J. I. Alvarez, L. Bourbonniere, S. Larouche, S. Terouz, J. M. Bin, M.-A. Lecuyer, et al. "Netrin 1 Regulates Blood-Brain Barrier Function and Neuroinflammation." Brain 138, no. 6 (June 1, 2015): 1598-1612. doi:10.1093/brain/awv092.


Post, A., W. J. Pannekoek, B. Ponsioen, M. J. Vliem, and J. L. Bos. "Rap1 Spatially Controls ArhGAP29 To Inhibit Rho Signaling during Endothelial Barrier Regulation." Molecular and Cellular Biology 35, no. 14 (July 15, 2015): 2495-2502. doi:10.1128/MCB.01453-14.


Potter, Daniel R., Gail Baimukanova, Sheila M. Keating, Xutao Deng, Jeffrey A. Chu, Stuart L. Gibb, Zhanglong Peng, et al. "Fresh Frozen Plasma and Spray-Dried Plasma Mitigate Pulmonary Vascular Permeability and Inflammation in Hemorrhagic Shock." Journal of Trauma and Acute Care Surgery 78 (June 2015): S7-17. doi:10.1097/TA.0000000000000630.


Rahbar, Elaheh, Jessica C Cardenas, Gyulnar Baimukanova, Benjamin Usadi, Roberta Bruhn, Shibani Pati, Sisse R Ostrowski, Pär I Johansson, John B Holcomb, and Charles E Wade. "Endothelial Glycocalyx Shedding and Vascular Permeability in Severely Injured Trauma Patients." Journal of Translational Medicine 13, no. 1 (December 2015): 117. doi:10.1186/s12967-015-0481-5.


Ramuz, M., A. Hama, J. Rivnay, P. Leleux, and R. M. Owens. "Monitoring of Cell Layer Coverage and Differentiation with the Organic Electrochemical Transistor." J. Mater. Chem. B 3, no. 29 (2015): 5971-77. doi:10.1039/C5TB00922G.


Richardson, D. D., S. Tol, E. Valle-Encinas, C. Pleguezuelos, R. Bierings, D. Geerts, and M. Fernandez-Borja. "The Prion Protein Inhibits Monocytic Cell Migration by Stimulating 1 Integrin Adhesion and Uropod Formation." Journal of Cell Science, July 9, 2015. doi:10.1242/jcs.165365.


Rom, Slava, Holly Dykstra, Viviana Zuluaga-Ramirez, Nancy L Reichenbach, and Yuri Persidsky. "miR-98 and Let-7g* Protect the Blood-brain Barrier under Neuroinflammatory Conditions." Journal of Cerebral Blood Flow & Metabolism, July 1, 2015. doi:10.1038/jcbfm.2015.154.


Rother, J., C. Richter, L. Turco, F. Knoch, I. Mey, S. Luther, A. Janshoff, E. Bodenschatz, and M. Tarantola. "Crosstalk of Cardiomyocytes and Fibroblasts in Co-Cultures." Open Biology 5, no. 6 (June 2015): 150038. doi:10.1098/rsob.150038.


Sabbineni, Harika, Abdulrahman Alwhaibi, Anna Goc, Fei Gao, Alanna Pruitt, and Payaningal R. Somanath. "Genetic Deletion and Pharmacological Inhibition of Akt1 Isoform Attenuates Bladder Cancer Cell Proliferation, Motility and Invasion." European Journal of Pharmacology 764 (October 2015): 208-14. doi:10.1016/j.ejphar.2015.06.059.


Sambale, F., S. Wagner, F. Stahl, R. R. Khaydarov, T. Scheper, and D. Bahnemann. "Investigations of the Toxic Effect of Silver Nanoparticles on Mammalian Cell Lines." Journal of Nanomaterials 2015 (2015): 1-9. doi:10.1155/2015/136765.


Schweitzer, Kelly S., Steven X. Chen, Sarah Law, Mary Van Demark, Christophe Poirier, Matthew J. Justice, Walter C. Hubbard, et al. "Endothelial Disruptive Proinflammatory Effects of Nicotine and E-Cigarette Vapor Exposures." American Journal of Physiology - Lung Cellular and Molecular Physiology 309, no. 2 (July 15, 2015): L175-87. doi:10.1152/ajplung.00411.2014.


Sleire, L, B S Skeie, I A Netland, H E Fřrde, E Dodoo, F Selheim, L Leiss, et al. "Drug Repurposing: Sulfasalazine Sensitizes Gliomas to Gamma Knife Radiosurgery by Blocking Cystine Uptake through System Xc−, Leading to Glutathione Depletion." Oncogene, March 23, 2015. doi:10.1038/onc.2015.60.


Spindler, Volker, Michael Meir, Balázs Vigh, Sven Flemming, Katharina Hütz, Christoph-Thomas Germer, Jens Waschke, and Nicolas Schlegel. "Loss of Desmoglein 2 Contributes to the Pathogenesis of Crohnʼs Disease." Inflammatory Bowel Diseases, June 2015, 1. doi:10.1097/MIB.0000000000000486.


Sugiyama, Michael G., Susan M. Armstrong, Changsen Wang, David Hwang, Howard Leong-Poi, Andrew Advani, Suzanne Advani, et al. "The Tie2-Agonist Vasculotide Rescues Mice from Influenza Virus Infection." Scientific Reports 5 (June 5, 2015): 11030. doi:10.1038/srep11030.


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ECIS electrodes (8W4E-µ) in combination with 3T3 cells and Sonja Lukic's careful cell culture technique have created a funny face in one of the wells. We enjoyed the little fellow a lot. Obviously, he got involved in some fight considering the swelling on his head. Maybe he got wounded???


Submitted by: Joachim Wegener

Universitat Regensburg

Institut für Analytische Chemie, Chemo- & Biosensorik

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