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Learn where to download a validated scale to measure canine pruritus severity
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Greetings!
Let's face it. Managing atopic dermatitis can get a little repetitive. So when something new comes along, it's easy for a dermatologist to get excited!
Novartis introduced Atopica almost 10 years ago. I launched RESPIT, a practical approach to allergy immunotherapy, 3 years ago. Where are the next innovations going to come from? I suspect that we'll be hearing a lot more about atopic dermatitis therapy from Pfizer in the next year. In the last issue, I summarized several of the basic research studies that Pfizer presented at the World Congress of Veterinary Dermatology. I'll continue this month with some of the fruits of that research, presented by Pfizer scientists.
--Jon Plant, DVM, DACVD
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More tidbits from the 2012 World Congress of Veterinary Dermatology, Vancouver B.C.
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1) A multicentre clinical trial to evaluate the efficacy and field safety of oclacitinib. Cosgrove S, et al.
Oclacitinib, a Pfizer Animal Health investigational janus kinase inhibitor, was evaluated by 23 veterinary dermatologists in 341 client-owned atopic dogs. In this placebo-controlled trial, both pruritus and lesion scores were significantly (p < 0.001, least squares mean) reduced in the oclacitinib group (0.4 mg/kg BID) compared to the placebo group. Diarrhea and emesis were the most commonly reported adverse effects.
2) Comparison of the janus kinase (JAK) inhibitor, oclacitinib, and prednisolone in canine models of pruritus. Fleck, T., et al. Utilizing the IL-31 pruritus model described in the August issue of this newsletter, Pfizer scientists evaluated the dose, onset of activity, and duration of activity of oclacitinib. Oral oclacitinib significantly reduced pruritus within 1 hour and for up to 16 hours after IL-31 injections. Oclacitinib also reduced pruritus within 1 hour of oral administration in a flea allergic dermatitis model. Prednisolone had a slower onset of antipruritic effect compared to oclacitinib in both IL-31 challenge and FAD models. 3) Oclacitinib for the treatment of pruritus and lesions associated with canine flea-allergic dermatitis. Wheeler, D.W., et al. Thirty-six dogs with flea allergic dermatitis were repeatedly infested over a 29-day period. During the last two weeks of the study, dogs received either placebo (T01), 0.4 mg/kg oclacitinib BID (T02), or 0.8 mg/kg oclacitinib BID (T03). Nocturnal pruritic behavior was videotaped for quantitative measurement and lesions were scored with a 10 cm visual analog scale. There was a significant reduction in pruritus in the T02 and T03 groups compared to the T01 (placebo) group (p < 0.012) for each of three post-treatment evaluations. Similarly, VAS scores for lesion severity were significantly reduced in the oclacitinib-treated dogs. There were no significant differences between T02 and T03 treatment group responses. |
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RESPIT on the Road
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We've continued to have a great deal of interest in RESPIT, with orders from new clinics every day. In the coming months, we will be exhibiting at the following meetings: - November 2012. George Muller-Peter Ihrke Veterinary Dermatology Seminar, Kauai, HI
- January 2013. North American Veterinary Conference, Orlando, FL (Booth 4127, Marriott)
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Profiles in Veterinary Dermatology
| Meet Dunbar Gram, DVM, DACVD
Animal Allergy & Dermatology
Dr. Gram received his DVM from Auburn  and completed his dermatology residency at North Carolina State University. He has a wide breadth of experience, from teaching, to pharmaceutical industry consulting, to private practice. If you have a chance to attend one of Dr. Gram's continuing education lectures, you won't be disappointed!
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| SkinVet Clinic
serves the dermatological needs of pets throughout Oregon and Washington. In the course of his practice, Dr. Plant developed RESPIT and has made it available to veterinarians across the US, together with the manufacturer, NelcoVet (US Vet Lic #359).
Jon Plant, DVM, DACVD
SkinVet Clinic, LLC
15800 SW Upper Boones Ferry Rd. #120
Lake Oswego, OR 97035
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