Comments below were gathered by our colleagues at the UK and Australian SMCs. Feel free to use these quotes in your reporting. To follow up, please contact the SMC (04 499 5476; smc@sciencemediacentre.co.nz).
Prof David Spiegelhalter, Winton Professor of the Public Understanding Of Risk, University of Cambridge, said:
"In my opinion, the methods, stats and reporting of results are all well below the standard I would expect in a rigorous study - to be honest I am surprised it was accepted for publication.
"All the comparisons are made with the 'untreated' control group, which only comprised 10 rats of each sex, the majority of which also developed tumours. Superficially they appear to have performed better than most of the treated groups (although the highest dose GMO and Roundup male groups also fared well), but there is no proper statistical analysis, and the numbers are so low they do not amount to substantial evidence. I would be unwilling to accept these results unless they were replicated properly."
Dr Wendy Harwood, senior scientist, John Innes Centre, said:
"The full data set has not been made available, but the findings do not contradict previous findings that genetic modification itself is a neutral technology, with no inherent health or environmental risks.
"We have to ask whether a diet with this level of maize is normal for rats. Another control with an alternative diet should have been included.
"Ten rats per group is a small number. For example, is the death of three out of ten controls compared to five out of ten males in the treated group statistically significant?
"The data from the control group fed non-GM maize is not included in the main figures making it very difficult to interpret the results.
"Without access to the full data, we can only say that these results cannot be interpreted as showing that GM technology itself is dangerous. However they do indicate possible concerns over long-term exposure to Roundup that require further study."
Prof Ottoline Leyser, Associate Director of the Sainsbury Laboratory, University of Cambridge, said:
"Like most of the GM debate, this work has very little to do with GM. The authors of the paper do not suggest that the effects are caused by genetic modification. They describe effects of the roundup herbicide itself and effects that they attribute to the activity of the enzyme introduced into the roundup resistant maize. There is good evidence that introducing genes in to crops using GM techniques results in fewer changes to the crops than introducing them using conventional breeding.
"This is unfortunately rather a subtle point and is somewhat tangential to the immediate issue."
Prof Anthony Trewavas, Professor of Cell Biology, University of Edinburgh, said:
"The control group is inadequate to make any deduction. Only 10 rodents so far as I can see and some of these develop tumours. Until you know the degree of variation in 90 or 180 (divided into groups of ten) control rodents these results are of no value.
"These figures for normal appearance of tumours in these rodent lines are surely available and using a line which is very susceptible to tumours can easily bias any result. To be frank it looks like random variation to me in a rodent line likely to develop tumours anyway."
Prof Tom Sanders, Head of the Nutritional Sciences Research Division, King's College London, said:
"Most toxicology studies are terminated at normal lifespan i.e. 2 years immortality is not an alternative.
"No food intake data is provided or growth data. This strain of rat is very prone to mammary tumours particularly when food intake is not restricted.
"There is a lack of information on the composition of the diet. One concern is whether there were mycotoxins in the maize meal because of improper storage. Zearalanone is a well know phytoestrogen produced by filamentous fungi that grow on maize.
"The statistical methods are unconventional, there is no clearly defined data analysis plan and probabilities are not adjusted for multiple comparisons."
Prof Mark Tester, Research Professor, Australian Centre for Plant Functional Genomics, University of Adelaide, said:
"The first thing that leaps to my mind is why has nothing emerged from epidemiological studies in the countries where so much GM has been in the food chain for so long? If the effects are as big as purported, and if the work really is relevant to humans, why aren't the "North Americans dropping like flies?! GM has been in the food chain for over a decade over there - and longevity continues to increase inexorably!
"And if the effects are as big as claimed, why have none of the previous 100+ plus studies by reputable scientists, in refereed journals, noticed anything at all?
"Finally, of course, this was a study of one event with one gene. To then extrapolate to all genetically modified crops is absurd. Even if it eventuates that there is an issue with this one event, or even this one gene, there is no reason at all for other genes introduced using GM to carry the same burden of risk. GM is an adaptation of a natural process that occurs all the time all over the planet - it is "only" a technology, a technique. It is how it is used that is more important. Generalisations about the risk of the technology per se are absurd.
Prof Alan Boobis, Professor of Biochemical Pharmacology, Imperial College London, said:
"Some of the effects are presented in a way that makes it difficult to evaluate their significance. For example, there does not appear to be a statistical analysis of the mammary tumours. These occur quite often in untreated animals. One would usually also take into account the historical controls in the testing lab, in reaching a conclusion. The pesticide itself has been subject to long term studies in rodents by others."
