Amphibians are one of the most threatened groups of vertebrates, with nearly a third of all species threatened with extinction. Reports of amphibian population declines on a global scale were first recognized over 25 years ago, prompting widespread concern among scientists. Frogs (comprising >80% of all amphibian species) are not only an essential part of natural ecosystems, but are often considered to be indicator species of overall environmental health. Monitoring some species can be challenging, however, because they have unpredictable or short breeding seasons, and are difficult to find at other times of year. I will discuss three of my research projects related to frog conservation, from systems in South Africa, the Midwestern U.S., and the local North Florida area, including how genetic tools help us understand the status of these fascinating creatures.